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Benzyl chloroformate

Benzyl chloroformate
Benzyl chloroformate structure
Chemical Name:
Benzyl chloroformate
CBZ;BCF;Bzcf;Z-CL;Z-CHLORIDE;CBZ CHLORIDE;Z-Cl (Cbz-Cl);CBZ-Cl (Z-Cl);Benzylchlorformiat;Benzyl Chlorofomate
Molecular Formula:
Formula Weight:
MOL File:

Benzyl chloroformate Properties

Melting point:
-20 °C
Boiling point:
103 °C20 mm Hg(lit.)
1.212 g/mL at 20 °C
vapor density 
1 (vs air)
vapor pressure 
1.39 psi ( 20 °C)
refractive index 
n20/D 1.519(lit.)
Flash point:
197 °F
storage temp. 
Miscible with ether, acetone and benzene.
Clear slightly yellow to slightly pink
Irritating; sharp, penetrating.
Water Solubility 
Moisture Sensitive
Stable. Incompatible with water, oxidizing agents. Combustible.
CAS DataBase Reference
501-53-1(CAS DataBase Reference)
NIST Chemistry Reference
Benzyl chloroformate(501-53-1)
EPA Substance Registry System
Carbonochloridic acid, phenylmethyl ester(501-53-1)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  T,C,N,F
Risk Statements  45-20-34-48/22-50/53-67-65-63-48/20-11-43-37-23
Safety Statements  53-26-36/37/39-45-60-61-62-46-36/37
RIDADR  UN 2924 3/PG 2
WGK Germany  3
RTECS  LQ5860000
Autoignition Temperature 590 °C
HS Code  2915 90 70
HazardClass  8
PackingGroup  I
Hazardous Substances Data 501-53-1(Hazardous Substances Data)
Toxicity LD50 orally in Rabbit: 3000 mg/kg
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H227 Combustible liquid Flammable liquids Category 4 Warning P210, P280, P370+P378, P403+P235,P501
H290 May be corrosive to metals Corrosive to Metals Category 1 Warning P234, P390, P404
H303 May be harmfulif swallowed Acute toxicity,oral Category 5 P312
H304 May be fatal if swallowed and enters airways Aspiration hazard Category 1 Danger
H314 Causes severe skin burns and eye damage Skin corrosion/irritation Category 1A, B, C Danger P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger P280, P305+P351+P338, P310
H330 Fatal if inhaled Acute toxicity,inhalation Category 1, 2 Danger P260, P271, P284, P304+P340, P310,P320, P403+P233, P405, P501
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning P261, P271, P304+P340, P312
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
H336 May cause drowsiness or dizziness Specific target organ toxicity,single exposure; Narcotic effects Category 3 Warning P261, P271, P304+P340, P312,P403+P233, P405, P501
H350 May cause cancer Carcinogenicity Category 1A, 1B Danger
H360 May damage fertility or the unborn child Reproductive toxicity Category 1A, 1B Danger
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger P260, P264, P270, P307+P311, P321,P405, P501
H372 Causes damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 1 Danger P260, P264, P270, P314, P501
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning P273, P391, P501
H401 Toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 2 P273, P501
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning P273, P391, P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233 Keep container tightly closed.
P234 Keep only in original container.
P240 Ground/bond container and receiving equipment.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P284 Wear respiratory protection.
P309 IF exposed or if you feel unwell:
P310 Immediately call a POISON CENTER or doctor/physician.
P390 Absorb spillage to prevent material damage.
P391 Collect spillage. Hazardous to the aquatic environment
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P307+P311 IF exposed: call a POISON CENTER or doctor/physician.
P370+P378 In case of fire: Use … for extinction.
P405 Store locked up.
P406 Store in corrosive resistant/… container with a resistant inner liner.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P501 Dispose of contents/container to..…

Benzyl chloroformate price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.14688 Benzyl chloroformate (stabilised) for synthesis. CAS 501-53-1, molar mass 170.59 g/mol., (stabilised) for synthesis 501-53-1 8146880250 $161 2018-11-23 Buy
TCI Chemical B3021 Benzyl Chloroformate >96.0%(T) 501-53-1 25g $28 2018-11-22 Buy
TCI Chemical B3021 Benzyl Chloroformate >96.0%(T) 501-53-1 250g $68 2018-11-22 Buy
Alfa Aesar A15682 Benzyl chloroformate, 95%, stab. with ca 0.1% sodium carbonate 501-53-1 250g $170 2018-11-13 Buy
Alfa Aesar A15682 Benzyl chloroformate, 95%, stab. with ca 0.1% sodium carbonate 501-53-1 50g $39.3 2018-11-13 Buy

Benzyl chloroformate Chemical Properties,Uses,Production

Chemical Properties

light yellow liquid


In peptide synthesis to block the amino group.

General Description

A colorless liquid with an acrid odor. Vapors irritate eyes and mucous membranes. Corrosive to metals and tissue. Long-term inhalation of low concentrations or short-term inhalation of high concentrations can result in adverse health effects.

Air & Water Reactions

Decomposes in moist air. Decomposes slowly in water to give corrosive hydrochloric acid and organic acids.

Reactivity Profile

Benzyl chloroformate decomposes slowly in water forming benzyl alcohol, HCl, and CO2. Gives off HCl fumes in moist air. Reacts with bases, both organic and inorganic. Attacks many metals especially in humid atmosphere [Handling Chemicals Safely 1980. p. 476]. Catalytic impurity incidents involving the iron catalyzed decomposition of benzoyl chloroformate have caused several explosions. The iron presumably comes from corrosion of steel storage tanks [Loss Prev. Bull., 1975, (003), 2]. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].


Highly toxic, emits very toxic phosgene fumes at 100C. Irritant to eyes.

Health Hazard

Inhalation causes mucous membrane irritation. Eyes are irritated by excessive exposure to vapor. Liquid causes severe irritation of eyes and irritates skin. Ingestion causes irritation of mouth and stomach.

Fire Hazard

Flash Point (°F): 176 ℃, 227 ℃; Vigorous decomposition occurs at these temperatures. These values are anomalous due to the effect of the decomposition products of benzyl chloride and CO2; Flammable Limits in Air (%): Not pertinent; Fire Extinguishing Agents: Dry chemical, foam, carbon dioxide; Fire Extinguishing Agents Not To Be Used: No data; Special Hazards of Combustion Products: Toxic phosgene, hydrogen chloride, and benzyl chloride vapors may form; Behavior in Fire: Containers may explode; Ignition Temperature: No data; Electrical Hazard: No data; Burning Rate: 4.0 mm/min.

Chemical Reactivity

Reactivity with Water Forms hydrogen chloride (hydrochloric acid). Reaction not very vigorous in cold water; Reactivity with Common Materials: Slow corrosion of metals; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Flush with and rinse with sodium bicarbonate or lime solution; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.

Purification Methods

The commercial material is usually better than 95% pure and may contain some toluene, benzyl alcohol, benzyl chloride and HCl. After long storage (e.g. two years at 4o, Greenstein and Winitz [The Chemistry of the Amino Acids Vol 2 p. 890, J Wiley and Sons NY, 1961] recommended that the liquid should be flushed with a stream of dry air, filtered and stored over sodium sulfate to remove CO2 and HCl which are formed by decomposition. It may further be distilled from an oil bath at a temperature below 85o because Thiel and Dent [Annalen 301 257 1898] stated that benzyloxycarbonyl chloride decarboxylates to benzyl chloride slowly at 100o and vigorously at 155o. Redistillation at higher vacuum below 85o yields material which shows no other peaks than those of benzyloxycarbonyl chloride by NMR spectroscopy. [Beilstein 6 IV 2278.] LACHRYMATORY and TOXIC.

Benzyl chloroformate Preparation Products And Raw materials

Raw materials

Preparation Products

Benzyl chloroformate Suppliers

Global( 298)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 China 19918 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 21967 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20680 55
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32457 55
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 CHINA 24196 60
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114 CHINA 6374 58
Chemwill Asia Co.,Ltd.
86-21-51861608;;; CHINA 24001 58
(323) 306-3136
(626) 453-0409 United States 8409 58
career henan chemical co
+86-371-86658258 CHINA 20104 58
Dalian Idery Biotechnology Co., Ltd. 0411-62696576/0411-66160116/15141125520
0411-66160116 China 87 58

View Lastest Price from Benzyl chloroformate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-15 Benzyl chloroformate
US $1.00 / kg 1kg 99% Customized career henan chemical co

Benzyl chloroformate Spectrum

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