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Benzyl chloroformate

Benzyl chloroformate
Benzyl chloroformate structure
CAS No.
501-53-1
Chemical Name:
Benzyl chloroformate
Synonyms
CBZ;BCF;Bzcf;Z-CL;Z-CHLORIDE;CBZ CHLORIDE;CBZ-Cl (Z-Cl);Z-Cl (Cbz-Cl);Benzylchlorformiat;Benzyl Chlorofomate
CBNumber:
CB7853678
Molecular Formula:
C8H7ClO2
Formula Weight:
170.59
MOL File:
501-53-1.mol

Benzyl chloroformate Properties

Melting point:
-20 °C
Boiling point:
103 °C20 mm Hg(lit.)
Density 
1.212 g/mL at 20 °C
vapor density 
1 (vs air)
vapor pressure 
1.39 psi ( 20 °C)
refractive index 
n20/D 1.519(lit.)
Flash point:
197 °F
storage temp. 
2-8°C
solubility 
Miscible with ether, acetone and benzene.
form 
Solution
color 
Clear slightly yellow to slightly pink
Odor
Irritating; sharp, penetrating.
Water Solubility 
decomposes
Sensitive 
Moisture Sensitive
Merck 
14,1801
Stability:
Stable. Incompatible with water, oxidizing agents. Combustible.
CAS DataBase Reference
501-53-1(CAS DataBase Reference)
EWG's Food Scores
1
FDA UNII
170BP0DD31
NIST Chemistry Reference
Benzyl chloroformate(501-53-1)
EPA Substance Registry System
Carbonochloridic acid, phenylmethyl ester (501-53-1)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS05,GHS06,GHS09,GHS02,GHS07,GHS08
Signal word  Danger
Hazard statements  H303-H318-H400-H225-H304-H332-H336-H360-H370-H372-H401-H227-H290-H330-H314-H335-H350-H410
Precautionary statements  P201-P261-P273-P280-P305+P351+P338-P310-P309-P501a-P202-P210-P233-P240-P241+P242+P243-P260-P264-P270-P271-P301+P330+P331+P310-P303+P361+P353+P310+P363-P304+P340+P310-P305+P351+P338+P310-P307+P311-P370+P378-P403+P233-P234-P284-P390-P391-P405-P406-P501
Hazard Codes  T,C,N,F
Risk Statements  45-20-34-48/22-50/53-67-65-63-48/20-11-43-37-23
Safety Statements  53-26-36/37/39-45-60-61-62-46-36/37
RIDADR  UN 2924 3/PG 2
WGK Germany  3
RTECS  LQ5860000
19
Autoignition Temperature 590 °C
TSCA  Yes
HS Code  2915 90 70
HazardClass  8
PackingGroup  I
Toxicity LD50 orally in Rabbit: 3000 mg/kg

Benzyl chloroformate price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.14688 Benzyl chloroformate (stabilised) for synthesis. CAS 501-53-1, molar mass 170.59 g/mol., (stabilised) for synthesis 501-53-1 8146880250 $170 2020-08-18 Buy
TCI Chemical B3021 Benzyl Chloroformate >96.0%(T) 501-53-1 25g $28 2020-06-24 Buy
TCI Chemical B3021 Benzyl Chloroformate >96.0%(T) 501-53-1 250g $73 2020-06-24 Buy
Alfa Aesar A15682 Benzyl chloroformate, 95%, stab. with ca 0.1% sodium carbonate 501-53-1 50g $42.5 2020-06-24 Buy
Alfa Aesar A15682 Benzyl chloroformate, 95%, stab. with ca 0.1% sodium carbonate 501-53-1 250g $177 2020-06-24 Buy

Benzyl chloroformate Chemical Properties,Uses,Production

Chemical Properties

light yellow liquid

Uses

In peptide synthesis to block the amino group.

General Description

A colorless liquid with an acrid odor. Vapors irritate eyes and mucous membranes. Corrosive to metals and tissue. Long-term inhalation of low concentrations or short-term inhalation of high concentrations can result in adverse health effects.

Air & Water Reactions

Decomposes in moist air. Decomposes slowly in water to give corrosive hydrochloric acid and organic acids.

Reactivity Profile

Benzyl chloroformate decomposes slowly in water forming benzyl alcohol, HCl, and CO2. Gives off HCl fumes in moist air. Reacts with bases, both organic and inorganic. Attacks many metals especially in humid atmosphere [Handling Chemicals Safely 1980. p. 476]. Catalytic impurity incidents involving the iron catalyzed decomposition of benzoyl chloroformate have caused several explosions. The iron presumably comes from corrosion of steel storage tanks [Loss Prev. Bull., 1975, (003), 2]. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

Hazard

Highly toxic, emits very toxic phosgene fumes at 100C. Irritant to eyes.

Health Hazard

Inhalation causes mucous membrane irritation. Eyes are irritated by excessive exposure to vapor. Liquid causes severe irritation of eyes and irritates skin. Ingestion causes irritation of mouth and stomach.

Chemical Reactivity

Reactivity with Water Forms hydrogen chloride (hydrochloric acid). Reaction not very vigorous in cold water; Reactivity with Common Materials: Slow corrosion of metals; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Flush with and rinse with sodium bicarbonate or lime solution; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.

Safety Profile

Poison by ingestion andinhalation routes. A powerful corrosive irritant. Thermallyunstable. Will react with water or steam to produce toxicand corrosive fumes and heat. Iron salts catalyze theexplosive decomposition of the ester. When heated todecomp

Purification Methods

The commercial material is usually better than 95% pure and may contain some toluene, benzyl alcohol, benzyl chloride and HCl. After long storage (e.g. two years at 4o, Greenstein and Winitz [The Chemistry of the Amino Acids Vol 2 p. 890, J Wiley and Sons NY, 1961] recommended that the liquid should be flushed with a stream of dry air, filtered and stored over sodium sulfate to remove CO2 and HCl which are formed by decomposition. It may further be distilled from an oil bath at a temperature below 85o because Thiel and Dent [Annalen 301 257 1898] stated that benzyloxycarbonyl chloride decarboxylates to benzyl chloride slowly at 100o and vigorously at 155o. Redistillation at higher vacuum below 85o yields material which shows no other peaks than those of benzyloxycarbonyl chloride by NMR spectroscopy. [Beilstein 6 IV 2278.] LACHRYMATORY and TOXIC.

Benzyl chloroformate Preparation Products And Raw materials

Raw materials

Preparation Products


Benzyl chloroformate Suppliers

Global( 328)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 19929 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21869 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22623 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24935 60
career henan chemical co
+86-371-86658258
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Shenzhen Nexconn Pharmatechs Ltd
15013857715
admin@nexconn.com CHINA 3000 58
QUALITY CONTROL CHEMICALS INC.
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(626) 453-0409 orders@qcchemical.com United States 8406 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
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Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23041 58
Chongqing Chemdad Co., Ltd
+86-13650506873
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View Lastest Price from Benzyl chloroformate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-07-10 Benzyl chloroformate
501-53-1
1KG 99% + 500 Ton/Tons per Month Hebei Xibaijie Biotechnology Co., Ltd.
2020-07-08 OEM Benzyl chloroformate
501-53-1
US $2.00 / KG 1KG 98% 1000 Kilogram/Kilograms per Month Hebei Xibaijie Biotechnology Co., Ltd.
2020-07-08 New Benzyl chloroformate
501-53-1
US $2.00 / KG 1KG 98% 1000 Kilogram/Kilograms per Month Hebei Xibaijie Biotechnology Co., Ltd.

Benzyl chloroformate Spectrum


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