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Benzyl chloroformate

Benzyl chloroformate
Benzyl chloroformate structure
Chemical Name:
Benzyl chloroformate
CBZ;BCF;Bzcf;Z-CL;Z-CHLORIDE;CBZ CHLORIDE;CBZ-Cl (Z-Cl);Z-Cl (Cbz-Cl);Benzyl chlorate;Benzylchlorformiat
Molecular Formula:
Formula Weight:
MOL File:

Benzyl chloroformate Properties

Melting point:
-20 °C
Boiling point:
103 °C20 mm Hg(lit.)
1.212 g/mL at 20 °C
vapor density 
1 (vs air)
vapor pressure 
1.39 psi ( 20 °C)
refractive index 
n20/D 1.519(lit.)
Flash point:
197 °F
storage temp. 
Store at +2°C to +8°C.
Miscible with ether, acetone and benzene.
Clear slightly yellow to slightly pink
Irritating; sharp, penetrating.
Water Solubility 
Moisture Sensitive
Stable. Incompatible with water, oxidizing agents. Combustible.
CAS DataBase Reference
501-53-1(CAS DataBase Reference)
EWG's Food Scores
NIST Chemistry Reference
Benzyl chloroformate(501-53-1)
EPA Substance Registry System
Carbonochloridic acid, phenylmethyl ester (501-53-1)
  • Risk and Safety Statements
Signal word  Danger
Hazard statements  H303-H318-H400-H225-H304-H332-H336-H360-H370-H372-H401-H227-H290-H330-H314-H335-H350-H410
Precautionary statements  P201-P261-P273-P280-P305+P351+P338-P310-P309-P501a-P202-P210-P233-P240-P241+P242+P243-P260-P264-P270-P271-P301+P330+P331+P310-P303+P361+P353+P310+P363-P304+P340+P310-P305+P351+P338+P310-P307+P311-P370+P378-P403+P233-P234-P284-P390-P391-P405-P406-P501
Hazard Codes  T,C,N,F
Risk Statements  45-20-34-48/22-50/53-67-65-63-48/20-11-43-37-23
Safety Statements  53-26-36/37/39-45-60-61-62-46-36/37
RIDADR  UN 2924 3/PG 2
WGK Germany  3
RTECS  LQ5860000
Autoignition Temperature 590 °C
HS Code  2915 90 70
HazardClass  8
PackingGroup  I
Toxicity LD50 orally in Rabbit: 3000 mg/kg

Benzyl chloroformate price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.14688 Benzyl chloroformate (stabilised) for synthesis. CAS 501-53-1, molar mass 170.59 g/mol., (stabilised) for synthesis 501-53-1 8146880250 $170 2020-08-18 Buy
TCI Chemical B3021 Benzyl Chloroformate >96.0%(T) 501-53-1 25g $29 2021-03-22 Buy
TCI Chemical B3021 Benzyl Chloroformate >96.0%(T) 501-53-1 250g $76 2021-03-22 Buy
Alfa Aesar A15682 Benzyl chloroformate, 95%, stab. with ca 0.1% sodium carbonate 501-53-1 50g $44.6 2021-03-22 Buy
Alfa Aesar A15682 Benzyl chloroformate, 95%, stab. with ca 0.1% sodium carbonate 501-53-1 250g $181 2021-03-22 Buy

Benzyl chloroformate Chemical Properties,Uses,Production

Chemical Properties

light yellow liquid


In peptide synthesis to block the amino group.

General Description

A colorless liquid with an acrid odor. Vapors irritate eyes and mucous membranes. Corrosive to metals and tissue. Long-term inhalation of low concentrations or short-term inhalation of high concentrations can result in adverse health effects.

Air & Water Reactions

Decomposes in moist air. Decomposes slowly in water to give corrosive hydrochloric acid and organic acids.

Reactivity Profile

Benzyl chloroformate decomposes slowly in water forming benzyl alcohol, HCl, and CO2. Gives off HCl fumes in moist air. Reacts with bases, both organic and inorganic. Attacks many metals especially in humid atmosphere [Handling Chemicals Safely 1980. p. 476]. Catalytic impurity incidents involving the iron catalyzed decomposition of benzoyl chloroformate have caused several explosions. The iron presumably comes from corrosion of steel storage tanks [Loss Prev. Bull., 1975, (003), 2]. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].


Highly toxic, emits very toxic phosgene fumes at 100C. Irritant to eyes.

Health Hazard

Inhalation causes mucous membrane irritation. Eyes are irritated by excessive exposure to vapor. Liquid causes severe irritation of eyes and irritates skin. Ingestion causes irritation of mouth and stomach.

Chemical Reactivity

Reactivity with Water Forms hydrogen chloride (hydrochloric acid). Reaction not very vigorous in cold water; Reactivity with Common Materials: Slow corrosion of metals; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Flush with and rinse with sodium bicarbonate or lime solution; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.

Safety Profile

Poison by ingestion andinhalation routes. A powerful corrosive irritant. Thermallyunstable. Will react with water or steam to produce toxicand corrosive fumes and heat. Iron salts catalyze theexplosive decomposition of the ester. When heated todecomp

Purification Methods

The commercial material is usually better than 95% pure and may contain some toluene, benzyl alcohol, benzyl chloride and HCl. After long storage (e.g. two years at 4o, Greenstein and Winitz [The Chemistry of the Amino Acids Vol 2 p. 890, J Wiley and Sons NY, 1961] recommended that the liquid should be flushed with a stream of dry air, filtered and stored over sodium sulfate to remove CO2 and HCl which are formed by decomposition. It may further be distilled from an oil bath at a temperature below 85o because Thiel and Dent [Annalen 301 257 1898] stated that benzyloxycarbonyl chloride decarboxylates to benzyl chloride slowly at 100o and vigorously at 155o. Redistillation at higher vacuum below 85o yields material which shows no other peaks than those of benzyloxycarbonyl chloride by NMR spectroscopy. [Beilstein 6 IV 2278.] LACHRYMATORY and TOXIC.

Benzyl chloroformate Preparation Products And Raw materials

Raw materials

Preparation Products

Benzyl chloroformate Suppliers

Global( 369)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 China 20012 60
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+86-371-66670886 China 20914 58
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0371-55170693 CHINA 22607 55
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027-59338440 CHINA 23035 58
Shanghai Longyu Biotechnology Co., Ltd.
+86 15821988213 China 2473 58
Chongqing Chemdad Co., Ltd
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View Lastest Price from Benzyl chloroformate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-11-25 Benzyl chloroformate
US $10.00 / KG 1KG 99% 5tons Hebei Guanlang Biotechnology Co., Ltd.
2021-07-09 Benzyl chloroformate
1KG 99% + 500 Ton/Tons per Month Hebei Xibaijie Biotechnology Co., Ltd.
2021-07-09 OEM Benzyl chloroformate
US $2.00 / KG 1KG 98% 1000 Kilogram/Kilograms per Month Hebei Xibaijie Biotechnology Co., Ltd.

Benzyl chloroformate Spectrum

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