ChemicalBook >> CAS DataBase List >>Neostigmine Methyl Sulfate
Neostigmine Methyl Sulfate
- CAS No.
- 51-60-5
- Chemical Name:
- Neostigmine Methyl Sulfate
- Synonyms
- NEOSTIGMINE METHYL SULPHATE;neostigmine metilsulfate;hodostin;vagostigmin;NEOSTIGIMINE BROMIDE;3-[[(DIMETHYLAMINO)CARBONYL]OXY]-N,N,N-TRIMETHYLBENZAMINIUM BROMIDE;GD-65;ar-32;sb-23;Stiglyn
- CBNumber:
- CB7853724
- Molecular Formula:
- C12H19N2O2.CH3O4S
- Molecular Weight:
- 334.39
- MDL Number:
- MFCD00011796
- MOL File:
- 51-60-5.mol
Last updated:2023-09-17 23:58:49
| Melting point | 175-177 °C(lit.) |
|---|---|
| storage temp. | -20°C |
| solubility | H2O: 1 g/mL |
| form | powder |
| color | white |
| Water Solubility | 1g/10mL |
| Merck | 14,6464 |
| CAS DataBase Reference | 51-60-5(CAS DataBase Reference) |
| FDA UNII | 98IMH7M386 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300-H315-H319-H334-H335 | |||||||||
| Precautionary statements | P261-P284-P301+P330+P331+P310-P304+P340-P305+P351+P338-P342+P311 | |||||||||
| Hazard Codes | T+ | |||||||||
| Risk Statements | 28-36/37/38-42/43-26/27/28 | |||||||||
| Safety Statements | 36-45-36/37/39-28A | |||||||||
| RIDADR | UN 2811 6.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | CY1225000 | |||||||||
| HazardClass | 6.1(a) | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29242990 | |||||||||
| Toxicity | LD50 in mice (mg/kg): 0.16 i.v.; 0.42 s.c.; 7.5 orally, (Randall, Lehmann) | |||||||||
| NFPA 704 |
|
Neostigmine Methyl Sulfate price More Price(32)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | N2126 | Neostigmine methyl sulfate | 51-60-5 | 1g | $58.2 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1460000 | Neostigmine methyl sulfate United States Pharmacopeia (USP) Reference Standard | 51-60-5 | 200mg | $436 | 2024-03-01 | Buy |
| TCI Chemical | N0447 | Neostigmine Methyl Sulfate >98.0%(N) | 51-60-5 | 5g | $113 | 2024-03-01 | Buy |
| TCI Chemical | N0447 | Neostigmine Methyl Sulfate >98.0%(N) | 51-60-5 | 25g | $410 | 2024-03-01 | Buy |
| Cayman Chemical | 23501 | Neostigmine (methyl sulfate) ≥98% | 51-60-5 | 500mg | $32 | 2024-03-01 | Buy |
Neostigmine Methyl Sulfate Chemical Properties,Uses,Production
Description
Neostigmine is a reversible inhibitor of acetylcholinesterase (AChE; Kd = 260 μM). In a rat model of knee joint inflammation, intrathecal administration of neostigmine (2-30 μg) increases endogenous acetylcholine levels and dose-dependently increases the latency of paw withdrawal in response to thermal and mechanical stimuli (ED50s = 6.6 and 3.5 μg, respectively). Neostigmine (5 μg, i.p.) restores muscle action potentials in mice with a thymopoietin-induced neuromuscular block. Formulations containing neostigmine have been used in the treatment of myasthenia gravis and Ogilvie syndrome.
Chemical Properties
Crystalline Solid
Uses
Cholinergic; miotic; antidote (curare)
Definition
ChEBI: Neostigmine methyl sulfate is an arylammonium sulfate salt. It has a role as an EC 3.1.1.8 (cholinesterase) inhibitor.
brand name
Prostigmine (ICN).
General Description
Neostigmine methylsulfate,(m-hydroxyphenyl)trimethylammonium methylsulfatedimethylcarbamate or the dimethylcarbamic ester of 3-hydroxyphenyltrimethylammoniummethylsulfate (Prostigminmethylsulfate), is a bitter, odorless, white, crystalline powder.It is very soluble in water and soluble in alcohol. Solutionsare stable and can be sterilized by boiling. The compound istoo hygroscopic for use in a solid form and thus is alwaysused as an injection. Aqueous solutions are neutral to litmus.
Clinical Use
The methylsulfate salt is used postoperatively as a urinarystimulant and in the diagnosis and treatment of myastheniagravis.
Purification Methods
Crystallise the sulfate from EtOH or Me2CO (m 143-144o). Its solubility in H2O is ~10%. [Beilstein 13 III 939.] (It is cholinergic and highly TOXIC.)
Neostigmine Methyl Sulfate Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 394)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan Marco Pharmaceutical Technology Co., Ltd. | +86-86-18572802410 +8618572802410 | sales@marcopht.com | China | 55 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Shanghai Longyu Biotechnology Co., Ltd. | +8615821988213 | info@longyupharma.com | China | 2531 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81148696 +8615536356810 | 1047@dideu.com | China | 3679 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
View Lastest Price from Neostigmine Methyl Sulfate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-09-17 | Neostigmine Methyl Sulfate
51-60-5
|
US $0.00-0.00 / kg | 25kg | 99% | 1000kg | Wuhan Marco Pharmaceutical Technology Co., Ltd. | |
 |
2021-11-19 | Neostigmine Methyl Sulfate
51-60-5
|
US $0.00 / KG | 10g | 99%min | 10kg | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2021-07-28 | Neostigmine Methyl Sulfate USP/EP/BP
51-60-5
|
US $1.10 / g | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited |
-
- Neostigmine Methyl Sulfate
51-60-5
- US $0.00-0.00 / kg
- 99%
- Wuhan Marco Pharmaceutical Technology Co., Ltd.
-
- Neostigmine Methyl Sulfate
51-60-5
- US $0.00 / KG
- 99%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Neostigmine Methyl Sulfate USP/EP/BP
51-60-5
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
51-60-5(Neostigmine Methyl Sulfate)Related Search:
Ammonium bisulfite
Tetramethylammonium hydroxide pentahydrate
PHENYLTRIMETHYLAMMONIUM METHOSULFATE
DIMETHYLAMMONIUM DIMETHYLCARBAMATE(DIMCARB)
AMMONIUM CARBAMATE
3-METHOXY-N-METHYLANILINE
Neostigmine Methyl Sulfate
Ammonium sulfate
Sulfuric acid
Ammonium bisulfate
1of4
A sulfuric acid neostigmine
(3-(dimethylcarbamoyloxy)phenyl)trimethyl-ammoniumethylsulfate
(3-hydroxyphenyl)trimethylammoniummethylsulfatedimethylcarbamicester
(m-hydroxyphenyl)trimethylammoniummethylsulfatedimethylcarbamate
PROSTIGMINE
NEOSTIGMINE METHYL SULFATE
3-[N,N-DIMETHYLCARBAMOYLOXY]-N,N,N-TRIMETHYLANILINIUM METHYL SULFATE
(3-HYDROXYPHENYL)TRIMETHYLAMMONIUM BROMIDE DIMETHYL CARBAMATE
(3-HYDROXYPHENYL)TRIMETHYLAMMONIUM METHYL SULFATE DIMETHYLCARBAMATE
3-[([DIMETHYLAMINO]CARBONYL)OXY]-N,N,N-TRIMETHYLBENZAMINIUM METHYL SULFATE
3-[[(DIMETHYLAMINO)CARBONYL]OXY]-N,N,N-TRIMETHYLBENZENAMINIUM BROMIDE
3-[[(DIMETHYLAMINO)CARBONYL]OXY]-N,N,N-TRIMETHYLBENZENAMINIUM METHYL SULFATE
(3-DIMETHYLCARBAMOYLOXYPHENYL)TRIMETHYLAMMONIUM BROMIDE
(3-DIMETHYLCARBAMOYLOXYPHENYL)TRIMETHYLAMMONIUM METHYL SULFATE
Intrastigmina
Metastigmin
Stiglyn
NEOSTIGMINE METHYL SULPHATE(RG)
Ethyl N-[2-[4-(phenoxy)phenoxy]ethyl]carbamate
Phenoxycarb
GD-65
3-(((dimethylamino)carbonyl)oxy)-n,n,n-trimethyl-benzenaminiumethylsulfat
3-(dimethylcarbamoxy)phenyltrimethylammoniummethylsulfate
ammonium,(m-hydroxyphenyl)trimethyl-,methylsulfate,dimethylcarbamate
Ammonium,[3-(dimethylcarbamoyloxy)phenyl]trimethyl-,methylsulfate
ar-32
Benzenaminium,3-[[(dimethylamino)carbonyl]oxy]-N,N,N-trimethyl-,methylsulfate
carbamicacid,n,n-dimethyl-,3-(trimethylammonio)phenylester,methylsulfate
carbamicacid,n,n-dimethyl-,3-dimethylaminophenylester,methosulfate
dimethyl-carbamicaciesterwith(m-hydroxyphenyl)trimethylammoniummethy
dimethylcarbamicesterof3-oxyphenyltrimethylammoniummethylsulfate
eustigminmethylsulfate
kirkstigminemethylsulfate
leostigminemethylsulfate
neoeserinemethylsulfate
neostigmeth
neostigminemethosulfate
neostigminemonomethylsulfate
normastigmin
philostigminmethylsulfate
polstigmine
proserin
proserinemethylsulfate
prostigminemethylsulfate
prostigminmethylsulfate
sb-23
stigmanolmethylsulfate
stigmosanmethylsulfate
synstigmine
syntostigmin
syntostigmin(injection)
syntostigmine
tl-1394
vagostigminemethylsulfate
Vagotigmine
Neostigmine methyl sulfate,98%
NEOSTIGMINE METHYL SULFATE(RG)
CAS51-60-5