tert-Butyl bromoacetate
- CAS No.
- 5292-43-3
- Chemical Name:
- tert-Butyl bromoacetate
- Synonyms
- TERT-BUTYL 2-BROMOACETATE;T-BUTYL BROMOACETATE;1-Butylbromoacetate;BROMOACETIC ACID TERT-BUTYL ESTER;tert-Butyl Bromoacet;T-BUTYL 2-BROMOACETATE;2-Methyl-2-propanyl bromoacetate;BrCH2C(O)OC(CH3)3;BUTYLBROMOACETATE-TERT;ert-Butyl bromoacetate
- CBNumber:
- CB7853739
- Molecular Formula:
- C6H11BrO2
- Molecular Weight:
- 195.05
- MDL Number:
- MFCD00000188
- MOL File:
- 5292-43-3.mol
- MSDS File:
- SDS
| Melting point | 44-47 °C |
|---|---|
| Boiling point | 50 °C10 mm Hg(lit.) |
| Density | 1.338 |
| vapor pressure | 1.62hPa at 25℃ |
| refractive index |
n |
| Flash point | 121 °F |
| storage temp. | 0-6°C |
| solubility | Chloroform, Ethyl Acetate (Slightly) |
| form | Liquid |
| Specific Gravity | 1.333 (20/4℃) |
| color | Clear colorless to yellow |
| Water Solubility | Miscible with ethanol, chloroform and ethyl acetate. Immiscible with water. |
| Sensitive | Lachrymatory |
| BRN | 1753010 |
| InChIKey | BNWCETAHAJSBFG-UHFFFAOYSA-N |
| CAS DataBase Reference | 5292-43-3(CAS DataBase Reference) |
| FDA UNII | LY42AF89SN |
| NIST Chemistry Reference | Acetic acid, bromo-, 1,1-dimethylethyl ester(5292-43-3) |
| EPA Substance Registry System | Acetic acid, bromo-, 1,1-dimethylethyl ester (5292-43-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS02,GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H226-H302-H314 | |||||||||
| Precautionary statements | P210-P233-P280-P301+P312-P303+P361+P353-P305+P351+P338 | |||||||||
| Hazard Codes | Xi,F | |||||||||
| Risk Statements | 10-36/37/38 | |||||||||
| Safety Statements | 26-24/25-16 | |||||||||
| RIDADR | UN 1993 3/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 19 | |||||||||
| Hazard Note | Irritant/Flammable/Lachrymatory | |||||||||
| TSCA | T | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29159080 | |||||||||
| NFPA 704 |
|
tert-Butyl bromoacetate price More Price(50)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 124230 | tert-Butyl bromoacetate 98% | 5292-43-3 | 10g | $32.7 | 2024-03-01 | Buy |
| Sigma-Aldrich | 124230 | tert-Butyl bromoacetate 98% | 5292-43-3 | 50g | $131 | 2024-03-01 | Buy |
| TCI Chemical | B1473 | tert-Butyl Bromoacetate >98.0%(GC) | 5292-43-3 | 25g | $62 | 2024-03-01 | Buy |
| TCI Chemical | B1473 | tert-Butyl Bromoacetate >98.0%(GC) | 5292-43-3 | 250g | $323 | 2024-03-01 | Buy |
| Alfa Aesar | A14917 | tert-Butyl bromoacetate, 98% | 5292-43-3 | 10g | $33.2 | 2024-03-01 | Buy |
tert-Butyl bromoacetate Chemical Properties,Uses,Production
Chemical Properties
clear colorless to yellow liquid
Uses
tert-Butyl bromoacetate is used as an intermediate in the production of dyes, pharmaceuticals, agrochemicals and in organic compounds. It finds application as an alkylating agent. It plays an important role to prepare (2-oxo-4-vinyl-azetidin-1-yl)-acetic acid tert-butyl ester and in collagenase inhibitors synthesis.
Uses
tert-Butyl Bromoacetate is a halogenated t-butyl acetate commonly used as an alkylating agent. tert-Butyl Bromoacetate is used in the synthesis of collagenase inhibitors.
Application
tert-Butyl bromoacetate has been used in the synthesis of:
nitrilotriacetic acid end-functionalized polystyrene by atom transfer radical polymerization
building block for substituted t-butyl acetates
dihydropyranyl prelinker which is useful in polymer-assisted deprotection of oligosacchararides
collagenase inhibitor (S,S,R)-(-)-actinonin It is the starting reagent for the synthesis of N-Oxalylglycine derivatives.
Preparation
Tert-butyl bromoacetate ester was synthesized using bromoacetic acid and isobutylene as raw materials,Amberlyst 15,a strong acidic cation exchange resin,as catalyst,and tert-butanol as modifier.
General Description
tert-Butyl bromoacetate serves as building blocks during the synthesis of model N-substituted oligoglycines (peptoids) containing an N-linked lactoside side-chain.
Flammability and Explosibility
Flammable
Safety
Tert-Butyl bromoacetate is a lachrymator. The reagent, reaction and its work-up should be handled in an adequately ventilated fume hood while wearing gloves, safety glasses and laboratory coat.
Purification Methods
Dissolve the ester in Et2O, wash it well with ice cold 10% aqueous K2CO3, dry it over CaCl2, filter and evaporate the Et2O, then fractionate it through a Vigreux column (p 11) in a vacuum. LACHRYMATORY. [Abramovitch et al. J Am Chem Soc 64 2274 1942, Abramovitch & Hauser J Am Chem Soc 65 986 1943, Beilstein 2 III 482.]
tert-Butyl bromoacetate Preparation Products And Raw materials
Raw materials
Preparation Products
1of4
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Yancheng Longshen Chemical Co.,Ltd. | +86-0515-88706880; +8618352073383 | sales@longshenchem.com | China | 79 | 55 |
| Jiangxi Sunway Chemical Co., Ltd. | +86-0794-5259909 +8615888611133 | dave@jxswchem.com | China | 22 | 58 |
| Jiangxi Sunway Chemical Co., Ltd. | +86-0794-5259909 +8615888611133 | dave@jxswchem.com | China | 22 | 58 |
| Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 | sales@finerchem.com | China | 2966 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12453 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5993 | 58 |
| Firsky International Trade (Wuhan) Co., Ltd | +8615387054039 | admin@firsky-cn.com | China | 436 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15371 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
Related articles
- Tert-Butyl bromoacetate: applications as alkylating agent and safety
- Tert-butyl bromoacetate is a versatile alkylating agent in synthetic processes, enhancing compound properties but requiring ca....
- Dec 15，2023
- tert-Butyl bromoacetate: Background technique, synthesis, applications and hazard
- tert-Buty bromoacetate is used for the synthesis of amino acids and peptides, and the synthesis of cyclic polyamino carboxylat....
- May 25，2023
- About tert-Butyl bromoacetate
- The invention relates to a synthesis method of tert-butyl bromoacetate, and the synthesis method comprises the following steps....
- Aug 19，2019
View Lastest Price from tert-Butyl bromoacetate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-19 | tert-Butyl bromoacetate
5292-43-3
|
US $5.00 / KG | 1KG | ≥99% | 500mt/year | Jinan Finer Chemical Co., Ltd | |
 |
2023-11-15 | tert-Butyl bromoacetate
5292-43-3
|
US $0.00-0.00 / kg | 1kg | 99% | 50000kg | Hebei Yibangte Import and Export Co. , Ltd. | |
 |
2023-10-14 | tert-Butyl bromoacetate
5292-43-3
|
US $0.00 / kg | 1kg | 0.99 | 20tons | Hebei Yanxi Chemical Co., Ltd. |
-
- tert-Butyl bromoacetate
5292-43-3
- US $5.00 / KG
- ≥99%
- Jinan Finer Chemical Co., Ltd
-
- tert-Butyl bromoacetate
5292-43-3
- US $0.00-0.00 / kg
- 99%
- Hebei Yibangte Import and Export Co. , Ltd.
-
- tert-Butyl bromoacetate
5292-43-3
- US $0.00 / kg
- 0.99
- Hebei Yanxi Chemical Co., Ltd.