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Tiotropium bromide hydrate

Tiotropium bromide hydrate Structure
Tiotropium bromide hydrate structure
CAS No.
139404-48-1
Chemical Name:
Tiotropium bromide hydrate
Synonyms
Tiotropium;BA-679 BR hydrate;TIOTROPIUM BROMDIE;tiotropium bromide hydrate;TiotropiuM broMide xhydrate;TIOTROPIUM BROMIDE MONOHYDRATE;Tiotropium bromide monohydrate CRS;Tiotropium Bromide hydrate (BA679BR);Tiotropium bromide hydrate USP/EP/BP;TiotropiuM BroMide MonohydrateTiotropiuM BroMide Monohydrate
CBNumber:
CB7855399
Molecular Formula:
C19H22BrNO4S2.H2O
Molecular Weight:
490.43
MDL Number:
MFCD00867027
MOL File:
139404-48-1.mol
MSDS File:
SDS
Last updated:2024-03-11 14:26:33
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Tiotropium bromide hydrate Properties

storage temp. Store at -20°C
solubility Sparingly soluble in water, soluble in methanol, practically insoluble in methylene chloride.
form Powder
InChIKey MQLXPRBEAHBZTK-SEINRUQRSA-M
CAS DataBase Reference 139404-48-1(CAS DataBase Reference)
FDA UNII L64SXO195N
NCI Drug Dictionary tiotropium bromide monohydrate

Pharmacokinetic data

Protein binding 72%
Excreted unchanged in urine 14 (of inhaled dose)
Volume of distribution 32(L/kg)
Biological half-life 5-6 days / Increased

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H312-H332-H319-H315-H361-H302-H373
Precautionary statements  P261-P271-P304+P340-P312-P264-P270-P301+P312-P330-P501-P260-P314-P501-P264-P280-P305+P351+P338-P337+P313P-P280-P302+P352-P312-P322-P363-P501-P264-P280-P302+P352-P321-P332+P313-P362-P201-P202-P281-P308+P313-P405-P501

Tiotropium bromide hydrate price More Price(19)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHR1890 Tiotropium Bromide Monohydrate Pharmaceutical Secondary Standard; Certified Reference Material 139404-48-1 50mg $342 2024-03-01 Buy
ApexBio Technology B1619 TiotropiumBromidehydrate 139404-48-1 5mg $133 2021-12-16 Buy
Biorbyt Ltd orb154653 Tiotropium Bromide hydrate (BA679BR) >98% 139404-48-1 250mg $615.4 2021-12-16 Buy
ApexBio Technology B1619 TiotropiumBromidehydrate 139404-48-1 50mg $741 2021-12-16 Buy
American Custom Chemicals Corporation CHM0077725 (1A,2B,4B,5A,7B)-7-[(HYDROXYDI-2-THIENYLACETY L)OXY]-9,9-DIMETHYL-3-OXA-9-AZONIATRICYCLO[3.3.1.02,4]NONANE BROMIDE HYDRATE 95.00% 139404-48-1 10MG $782.23 2021-12-16 Buy
Product number Packaging Price Buy
PHR1890 50mg $342 Buy
B1619 5mg $133 Buy
orb154653 250mg $615.4 Buy
B1619 50mg $741 Buy
CHM0077725 10MG $782.23 Buy

Tiotropium bromide hydrate Chemical Properties,Uses,Production

Chemical Properties

White or yellowish-white powder or crystals.

Uses

Tiotropium Bromide hydrate is a hydrate of tiotropium bromide (Spiriva; Tiova; BA 679BR; tiopropium) that is an anticholinergic and bronchodilator and a muscarinic receptor antagonist. Although tiotropium Bromide (Spiriva; Tiova; BA 679BR; tiopropium) doe

Definition

ChEBI: Tiotropium bromide hydrate is a hydrate that is the monohydrate form of tiotropium bromide. Used for maintenance treatment of airflow obstruction in patients with chronic obstructive pulmonary disease. It has a role as a muscarinic antagonist and a bronchodilator agent.

Clinical Use

Maintenance treatment of chronic obstructive pulmonary disease

Drug interactions

Potentially hazardous interactions with other drugs
Avoid administration with other anti-cholinergic drugs.
Anti-arrhythmics: increased risk of antimuscarinic side effects with disopyramide.

Metabolism

Tiotropium is excreted largely unchanged in the urine, although it may undergo some metabolism by non-enzymatic cleavage and by the cytochrome P450 isoenzymes CYP2D6 and CYP3A4.

Tiotropium bromide hydrate synthesis

136310-64-0
74-83-9
139404-48-1
Synthesis of Tiotropium bromide hydrate from Scopine-2,2-dithienyl glycolate and Methyl bromide

Tiotropium bromide hydrate Preparation Products And Raw materials

Raw materials

3-Oxa-9-azoniatricyclo[3.3.1.02,4]nonane, 7-[(2,2-di-2-thienylacetyl)oxy]-9,9-dimethyl-, bromide (1:1), (1α,2β,4β,5α,7β)- Scopine-2,2-dithienyl glycolate

Preparation Products

Tiotropium bromide hydrate Suppliers

Global( 305)Suppliers
Supplier Tel Email Country ProdList Advantage
Anhui Dexinjia Biopharm Co., Ltd
+86-531-82375818 +86-15064153060 alice@jndxj.com China 309 58
Hebei Yibangte Import and Export Co. , Ltd. 		+86-0311-85030958 +8615532196582 lisa@yibangte.com China 2987 58
Anhui Zhongda Biotechnology Co., Ltd 		+8619956560829 justine@zhongda-biotech.com China 300 58
Wuhan Xinhao Biotechnology Co., Ltd 		+86-18120578002 +86-18120578002 xinhao-6@xinhaoshengwu.com China 350 58
Frapp's ChemicalNFTZ Co., Ltd. 		+86 (576) 8169-6106 sales@frappschem.com China 885 50
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1811 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21691 55
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9348 55
Nanjing Finetech Chemical Co., Ltd. 		025-85710122 17714198479 sales@fine-chemtech.com CHINA 885 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
Supplier Advantage
Anhui Dexinjia Biopharm Co., Ltd
58
Hebei Yibangte Import and Export Co. , Ltd. 		58
Anhui Zhongda Biotechnology Co., Ltd 		58
Wuhan Xinhao Biotechnology Co., Ltd 		58
Frapp's ChemicalNFTZ Co., Ltd. 		50
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
Henan Tianfu Chemical Co.,Ltd. 		55
Hangzhou FandaChem Co.,Ltd. 		55
Nanjing Finetech Chemical Co., Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60

View Lastest Price from Tiotropium bromide hydrate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Tiotropium bromide hydrate pictures 2024-04-02 Tiotropium bromide hydrate
139404-48-1
 US $10.00-100.00 / kg 1kg 99% 100 tons Wuhan Xinhao Biotechnology Co., Ltd
Tiotropium Bromide monohydrate pictures 2024-03-28 Tiotropium Bromide monohydrate
139404-48-1
 US $0.00 / KG 25KG ≥99% Inquiry PNP Biotech Co. Ltd
Tiotropium bromide hydrate pictures 2024-03-16 Tiotropium bromide hydrate
139404-48-1
 US $0.00 / KG 100g 98%+ 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD

Tiotropium bromide hydrate Spectrum

Tiotropium bromide hydrate(139404-48-1)1HNMR

139404-48-1(Tiotropium bromide hydrate)Related Search:

Tiotropium bromide 2-Thiophenecarboxaldehyde Dimidium bromide Chloral hydrate ETHANE
Dacthal Dimethyl sulfate Allyl bromide Rocuronium bromide OXITROPIUM BROMIDE
N,N-Dimethylformamide Dimethyl phthalate Dimethyl ether Dimethyl fumarate LACTOSE, MONOHYDRATE
Thifensulfuron methyl Tetrahydrothiophene Cephalothin sodium

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(1R,2R,4S,5S,7S)-7-[2-HYDROXY-2,2-DI(2-THIENYL)ACETOXY]-9,9-DIMETHYL-3-OXA-9-AZONIATRICYCLO[3.3.1.02,4] NONANE BROMIDE MONOHYDRATE tiotropium bromide hydrate TIOTROPIUM BROMIDE MONOHYDRATE TIOTROPIUM BROMDIE Tiotropium (1a,2b,4b,5a,7b)-7-[(hydroxydi-2-thienylacety l)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane bromide hydrate (1a,2b,4b,5a,7b)-7-[(hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane bromide (1α,2β,4β,5α,7β)-7-[(Hydroxydi-2-thienylacety l)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane bromide hydrate TiotropiuM broMide xhydrate TiotropiuM BroMide Monohydrate or tiotropiuM broMide hydrate TiotropiuM BroMide MonohydrateTiotropiuM BroMide Monohydrate Tiotropium Bromide hydrate (BA679BR) Tiotropium bromide monohydrate CRS BA-679 BR hydrate 3-Oxa-9-azoniatricyclo[3.3.1.02,4]nonane, 7-[(hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-, bromide, hydrate, (1α,2β,4β,5α,7β)- (9CI) (1R,2R,4S,5S,7s)-7-(2-hydroxy-2,2-di(thiophen-2-yl)acetoxy)-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-ium bromide hydrate Tiotropium bromide hydrate USP/EP/BP 139404-48-1 39404-48-1 C19H22NO4S2BrxH2O C19H22NO4S2BrH2O C19H22BrNO4S2 BrC19H22NO4S2 C19H22BrNO4S2xH2O API Inhibitors 139404-48-1