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Isosorbide-2-Acetate

Isosorbide-2-Acetate structure

CAS No.: 13042-39-2

Chemical Name:: Isosorbide-2-Acetate

Synonyms: 2-Acetyl-isosorbide;Isosorbide Impurity 5;Isosorbide Impurity 15;Isosorbide Dinitrate Impurity 5;1,4:3,6-dianhydro-D-glucitol 2-acetate;1,4:3,6-Dianhydro-2-O-acetyl-D-glucitol;D-Glucitol, 1,4:3,6-dianhydro-, 2-acetate;(3S,3aR,6R,6aR)-6-hydroxyhexahydrofuro[3,2-b]furan-3-yl acetate;(6-Hydroxy-2,3,3a,5,6,6a-hexahydrofuro[2,3-d]furan-3-yl) acetate;(6-hydroxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl) acetate

CBNumber:: CB7874929

Molecular Formula:: C8H12O5

Molecular Weight:: 188.18

MDL Number:: MFCD09264290

MOL File:: 13042-39-2.mol

Last updated:2023-05-24 21:37:54

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Isosorbide-2-Acetate Properties

Melting point	78 °C
Boiling point	323.0±42.0 °C(Predicted)
Density	1.34±0.1 g/cm3(Predicted)
pka	13.35±0.40(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P280-P301+P312-P302+P352-P305+P351+P338

Isosorbide-2-Acetate price More Price(8)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	293150	1,4:3,6-Dianhydro-2-O-acetyl-D-glucitol	13042-39-2	10g	$359	2021-12-16	Buy
Biosynth Carbosynth	MD09909	1,4:3,6-Dianhydro-2-O-acetyl-D-glucitol	13042-39-2	100g	$500	2021-12-16	Buy
American Custom Chemicals Corporation	CHM0077644	ISOSORBIDE-2-ACETATE 95.00%	13042-39-2	5G	$909.56	2021-12-16	Buy
Biosynth Carbosynth	MD09909	1,4:3,6-Dianhydro-2-O-acetyl-D-glucitol	13042-39-2	5G	$50	2021-12-16	Buy
Biosynth Carbosynth	MD09909	1,4:3,6-Dianhydro-2-O-acetyl-D-glucitol	13042-39-2	10g	$80	2021-12-16	Buy

Product number	Packaging	Price	Buy
293150	10g	$359	Buy
MD09909	100g	$500	Buy
CHM0077644	5G	$909.56	Buy
MD09909	5G	$50	Buy
MD09909	10g	$80	Buy

Isosorbide-2-Acetate Chemical Properties,Uses,Production

Chemical Properties

Isosorbide-2-acetate is a colourless, crystalline substance with a melting point of 75°-76°C. It has a TLC (diethyl ether) value of Rf=0.28 and a specific rotation of [α]D 20 =+77.1° (c=1.12, ethyl acetate). It is an important intermediate in the synthesis of isosorbide-5-mononitrate, a well-known organic nitrate drug.

Uses

1,4:3,6-Dianhydro-2-O-acetyl-D-glucitol is a useful reagent in the practical enzymic synthesis of isosorbide-2-acetate.

Preparation

The synthesis of isosorbide-2-acetate involves dissolving 2.30 g (10 mmol) of isosorbide-2,5-diacetate in 15 ml of acetone and 5 ml of n-heptanol. Then, 200 mg of lipase from Pseudomonas fluorescens (SAM II, Amano Pharmaceuticals) is added, and the mixture is stirred at room temperature for 2 days. After that, the enzyme is removed by filtration, and the resulting solid is washed thoroughly with acetone. The solvent, excess n-heptanol, and heptyl acetate residue are removed by distillation.
The yield is 1.71 g (9.09 mmol) of isosorbide-2-acetate, which is a colourless crystalline substance with a melting point of 75°-76°C. The overall yield is 91%.
US5538891A

Isosorbide-2-Acetate Preparation Products And Raw materials

Raw materials

Preparation Products

Isosorbide-2-Acetate Suppliers

Global( 60)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Xiamen AmoyChem Co., Ltd	+86-592-6051114 +8618959220845	sales@amoychem.com	China	6387	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
SIMAGCHEM CORP	+86-13806087780	sale@simagchem.com	China	17367	58
Shanghai UCHEM Inc.	+862156762820 +86-13564624040	sales@myuchem.com	China	6710	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	CHINA	52867	58
CD Chemical Group Limited	+8615986615575	info@codchem.com	China	20356	58
Jiangsu Nata Opto-electronic Material Co.,Ltd.	+86-0512-62520998 +86-15030927757	gaoym@natachem.com	China	229	58
PT CHEM GROUP LIMITED	+86-85511178 +86-85511178	peter68@ptchemgroup.com	China	35453	58

Supplier	Advantage
Xiamen AmoyChem Co., Ltd	58
Hubei xin bonus chemical co. LTD	58
BOC Sciences	58
CONIER CHEM AND PHARMA LIMITED	58
SIMAGCHEM CORP	58
Shanghai UCHEM Inc.	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
CD Chemical Group Limited	58
Jiangsu Nata Opto-electronic Material Co.,Ltd.	58
PT CHEM GROUP LIMITED	58

View Lastest Price from Isosorbide-2-Acetate manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2023-05-25	Isosorbide-2-Acetate 13042-39-2	US $0.00 / g	50g	98%	5kg	Jiangsu Nata Opto-electronic Material Co.,Ltd.

Isosorbide-2-Acetate
13042-39-2
US $0.00 / g
98%
Jiangsu Nata Opto-electronic Material Co.,Ltd.

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1of4

1,4:3,6-dianhydro-D-glucitol 2-acetate (6-Hydroxy-2,3,3a,5,6,6a-hexahydrofuro[2,3-d]furan-3-yl) acetate Acetic acid (3S,3aR,6R,6aR)-6-hydroxyhexahydrofuro[3,2-b]furan-3-yl ester (6-hydroxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl) acetate (6-hydroxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl) ethanoate acetic acid (6-hydroxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl) ester 2-Acetyl-isosorbide 1,4:3,6-Dianhydro-2-O-acetyl-D-glucitol (3S,3aR,6R,6aR)-6-hydroxyhexahydrofuro[3,2-b]furan-3-yl acetate Isosorbide Impurity 5 D-Glucitol, 1,4:3,6-dianhydro-, 2-acetate Isosorbide Impurity 15 Isosorbide Dinitrate Impurity 5 13042-39-2