ChemicalBook >> CAS DataBase List >>Zorubicin

Zorubicin

CAS No.
54083-22-6
Chemical Name:
Zorubicin
Synonyms
RUBIDAZON;ZORUBICIN;Rubidazone;Ccris 2260;Brn 1417621;Zorubicin [inn];Daunomycin benzoylhydrazone;Benzoylhydrazone daunorubicin;N-[1-[(2S,4S)-4-(4-Amino-5-hydroxy-6-methyloxan-2-yl)oxy-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-3,4-dihydro-1H-tetracen-2-yl]ethylideneamino]benzamide;N-[(E)-1-[(2S,4S)-4-(4-amino-5-hydroxy-6-methyloxan-2-yl)oxy-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-3,4-dihydro-1H-tetracen-2-yl]ethylideneamino]benzamide
CBNumber:
CB7875401
Molecular Formula:
C34H35N3O10
Molecular Weight:
645.66
MDL Number:
MFCD00866363
MOL File:
54083-22-6.mol
Last updated:2022-12-21 16:56:50

Zorubicin Properties

Boiling point 675.08°C (rough estimate)
Density 1.2920 (rough estimate)
refractive index 1.7800 (estimate)
FDA UNII V25F9362OP
ATC code L01DB05

Zorubicin price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
American Custom Chemicals Corporation API0008773 ZORUBICIN 95.00% 54083-22-6 5MG $495.59 2021-12-16 Buy
Product number Packaging Price Buy
API0008773 5MG $495.59 Buy

Zorubicin Chemical Properties,Uses,Production

Originator

Zorubicin Hydrochloride,ZYF Pharm Chemical

Uses

Antineoplastic.

Manufacturing Process

9.024 g daunorubicin-hydrochloride (its preparation and physicochemical properties have been described in British Patent Specification No 985 598) was dissolved in 800 ml ethanol and mixed with 2.5 ml acetic acid and 2.162 g benzoyl hydrazide and heated for 24 hours at 60°C. On cooling the obtained precipitate was filtered off, washed with 100 ml of ethanol and dried in vacuum at 20°C. It was dissolved in water and small quantity of insoluble product was filtered off, the filtrate was lyophilized. (1-(4-((3-Amino-2,3,6- trideoxy-α,L-lyxohexopyranosyl)oxy)-1,2,3,4,6,11-hexahydro-2,5,12- trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl)ethylidene)hydrazide dihydrochloride (zorubicin) was obtained as red-orange crystalline powder; [α] D 20 = -50° (c=0.2 in water). The compound may be employed in the form of different non-toxic salts such as benzoates, fumarates, maleates, tartrates and so on. The best among these compounds proves to be daunorubicin benzoylhydrazone (rubidazone), which is less cardiotoxic (French Pat. No. 1,578,722 published in 1967, Class CO7d).

Therapeutic Function

Antineoplastic, Antileukemic

Zorubicin Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 9)Suppliers
Supplier Tel Email Country ProdList Advantage
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28180 58
Supplier Advantage
Hubei Jusheng Technology Co.,Ltd.
58
N-[1-[(2S,4S)-4-(4-Amino-5-hydroxy-6-methyloxan-2-yl)oxy-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-3,4-dihydro-1H-tetracen-2-yl]ethylideneamino]benzamide Benzoic acid 2-[1-[(2S,4S)-4-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxonaphthacen-2-yl]ethylidene] hydrazide Daunomycin benzoylhydrazone Rubidazone ZORUBICIN Benzoic acid, 1-(2S,4S)-4-(3-amino-2,3,6-trideoxy-.alpha.-L-lyxo-hexopyranosyl)oxy-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenylethylidenehydrazide RUBIDAZON Benzoic acid, (1-(4-((3-amino-2,3,6-trideoxy-alpha,L-lyxo-hexopyranosyl)oxy)-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl)ethylidene)hydrazide, (2S-cis)- Benzoylhydrazone daunorubicin Brn 1417621 Ccris 2260 Zorubicin [inn] N-[(E)-1-[(2S,4S)-4-(4-amino-5-hydroxy-6-methyloxan-2-yl)oxy-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-3,4-dihydro-1H-tetracen-2-yl]ethylideneamino]benzamide Benzoic acid, 2-[1-[(2S,4S)-4-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl]ethylidene]hydrazide 54083-22-6 C34H35N3O10