Meclofenamic acid
- CAS No.
- 644-62-2
- Chemical Name:
- Meclofenamic acid
- Synonyms
- Arquel;INF 4668;Meclofen;NSC 95309;Meclorfenamic;meclofenamicaci;Meclofenamic acid;Meclophenamic acid;Meclofenamic acid USP/EP/BP;Meclofenamic acid Solution, 100ppm
- CBNumber:
- CB7875562
- Molecular Formula:
- C14H11Cl2NO2
- Molecular Weight:
- 296.15
- MDL Number:
- MFCD00072053
- MOL File:
- 644-62-2.mol
- MSDS File:
- SDS
| Melting point | 257-259°C |
|---|---|
| Boiling point | 399.4±42.0 °C(Predicted) |
| Density | 1.3567 (rough estimate) |
| refractive index | 1.6070 (estimate) |
| storage temp. | Refrigerator |
| solubility | Chloroform (Slightly), Methanol (Slightly, Heated) |
| pka | pKa 4.0 (Uncertain) |
| form | Solid |
| color | Off-White to Light Orange |
| FDA UNII | 48I5LU4ZWD |
| ATC code | M01AG04,M02AA18 |
| EPA Substance Registry System | Benzoic acid, 2-[(2,6-dichloro-3-methylphenyl)amino]- (644-62-2) |
Meclofenamic acid price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | M202750 | MeclofenamicAcid | 644-62-2 | 5mg | $185 | 2021-12-16 | Buy |
| TRC | M202750 | MeclofenamicAcid | 644-62-2 | 25mg | $850 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0037298 | MECLOFENAMIC ACID 95.00% | 644-62-2 | 5MG | $756.25 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0037298 | MECLOFENAMIC ACID 95.00% | 644-62-2 | 50MG | $1732.5 | 2021-12-16 | Buy |
| CSNpharm | CSN24828 | Meclofenamicacid | 644-62-2 | 25mg | $882 | 2021-12-16 | Buy |
Meclofenamic acid Chemical Properties,Uses,Production
Chemical Properties
White Crystalline Solid
Originator
Meclomen,Warner Lambert,US,1980
Uses
Anti-inflammatory; antipyretic
Uses
Meclofenamic acid is used for the same conditions as flufenamic acid.
Definition
ChEBI: An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 2,6-dichloro-3-methylphenyl group. A non-steroidal anti-inflammatory drug, it is used as the sodium salt for the treatment of dysmenorrhoe (painful periods), osteoarthritis and rheumatoid arthritis.
Manufacturing Process
A mixture consisting of 22.7 g potassium o-bromobenzoate, 16.6 g 2,6- dichloro-3-methylaniline, 12 ml N-ethylmorpholine, 60 ml diethylene glycol dimethyl ether, and 1.0 g anhydrous cupric bromide is heated in a nitrogen atmosphere at 145°C to 155°C for 2 hours. The reaction mixture is diluted with 60 ml diethylene glycol dimethyl ether and acidified with 25 ml concentrated hydrochloric acid. The acidic mixture is diluted with 100 ml of water and the liquid phase decanted from the insoluble oil. The insoluble oil is stirred with methanol and the crystalline N-(2,6-dichloro-3-methylphenyl) anthranilic acid which separates is collected and washed with methanol. The product, after recrystallization from acetone-water mixture, melts at 248°C to 250°C.
brand name
Meclomen (Parke-Davis, Portugal, USA), Meclodol (Parke Davis, Italy), Stadium (Menarini, Belgium).
Therapeutic Function
Antiinflammatory
Clinical Use
Meclofenamat is a nonsteroidal anti-inflammatory drug used for the treatment of mild to moderate pain, musculoskeletal, and joint disorders like rheumatoid arthritis and osteoarthritis as well as dysmenorrhoea. Meclofenamate inhibits COX-1 and COX-2 and modifies ion channels.
Side effects
Meclofenamic acid is available as its sodium salt hydrate. This drug is indicated for the relief of acute and chronic rheumatoid arthritis and osteoarthritis. Gastrointestinal distress, including diarrhea, nausea, vomiting, and abdominal pain, is the most commonly reported adverse effect.
Synthesis
Meclofenamic acid, N-(2,6-dichloro-m-tolyl)anthranylic acid (3.2.20), is synthesized analogous to flufenamic acid, by the reaction of potassium salt of 2-bromobenzoic acid with 2,6-dichloro-3-methylaniline in the presence of copper (II) bromide in a mixture of N-ethylmorpholine and diglyme [82,83].
Meclofenamic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569265 +86-18612256290 | 1056@dideu.com | China | 3683 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29322 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 | info@afinechem.com | CHINA | 15377 | 58 |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9702 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | 1026@dideu.com | China | 9165 | 58 |
View Lastest Price from Meclofenamic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-20 | Meclofenamic acid
644-62-2
|
US $1.00-1.00 / KG | 1g | 99% | 50tons | Shaanxi Dideu Medichem Co. Ltd | |
 |
2021-06-10 | Meclofenamic acid USP/EP/BP
644-62-2
|
US $1.10 / g | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited |
-
- Meclofenamic acid
644-62-2
- US $1.00-1.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- Meclofenamic acid USP/EP/BP
644-62-2
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited