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thiopropazate

CAS No.
84-06-0
Chemical Name:
thiopropazate
Synonyms
Dartal;Dartalan;hiopropazate;thiopropazate;4-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-1-piperazineethanol=acetate;1-Piperazineethanol, 4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-, 1-acetate;Acetic acid 2-[4-[3-(2-chloro--10H-phenothiazin-10-yl)propyl]-1-piperazinyl]ethyl;Acetic acid 2-[4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-1-piperazinyl]ethyl ester
CBNumber:
CB7887882
Molecular Formula:
C23H28ClN3O2S
Molecular Weight:
446.01
MDL Number:
MFCD00866636
MOL File:
84-06-0.mol
Last updated:2023-04-23 13:52:06

thiopropazate Properties

Boiling point bp0.1 214-218°
Density 1.1147 (rough estimate)
refractive index 1.6100 (estimate)
pka pKa 3.20(H2O (extrap) t = 24±1 I ~ 0.002) (Uncertain);7.15(H2O (extrap) t = 24±1 I ~ 0.002) (Uncertain)
Water Solubility 8.92mg/L(24 ºC)
FDA UNII 0JFY081Q2X
ATC code N05AB05

thiopropazate price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
American Custom Chemicals Corporation API0012614 THIOPROPAZATE 95.00% 84-06-0 5MG $495.85 2021-12-16 Buy
Product number Packaging Price Buy
API0012614 5MG $495.85 Buy

thiopropazate Chemical Properties,Uses,Production

Originator

Dartal,Searle,US,1957

Definition

ChEBI: A phenothiazine derivative in which 10H-phenothiazine has a chloro subsitituent at the 2-position and a 3-[4-(2-acetoxyethyl)piperazin-1-yl]propyl group at N-10.

Manufacturing Process

A mixture of 155 parts of 2-chloro-10-(γ-chloropropyl)phenothiazine, 75 parts of sodium iodide, 216 parts of piperazine and 2,000 parts of butanone is refluxed for 8 hours, concentrated and extracted with dilute hydrochloric acid. The extract is rendered alkaline by addition of dilute potassium carbonate and extracted with ether. This ether extract is washed with water, dried over anhydrous potassium carbonate, filtered and evaporated. Vacuum distillation at 0.1 mm pressure yields 2-chloro-10-(γ-piperazinopropyl)phenothiazine at about 214°C to 218°C.
A mixture of 50 parts of the distillate, 25.6 parts of β-bromoethyl acetate, 10.7 parts of potassium carbonate and 400 parts of toluene is stirred at reflux temperature for 16 hours. The mixture is heated with water. The organic layer is separated, washed with water and extracted with dilute hydrochloric acid. The resulting extract is washed with benzene, rendered alkaline and extracted with benzene. The resulting benzene solution is dried over anhydrous potassium carbonate, filtered and concentrated. The residue is dissolved in 300 parts of ethanol and treated with 2.2 equivalents of a 25% solution of anhydrous hydrochloric acid in 2-propanol. The resulting crystals are recrystallized from 400 parts of ethanol and 10 parts of water. The dihydrochloride of N-(β-acetoxyethyl)-N'-[γ-(2'-chloro-10'- phenothiazine)propyl]piperazine melts unsharply at about 200°C to 230°C.

brand name

Thiopropazate is INN and BAN.

Therapeutic Function

Antipsychotic

thiopropazate Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 3)Suppliers
Supplier Tel Email Country ProdList Advantage
Shaanxi Didu New Materials Co. Ltd
+86-89586680 +86-13289823923 1026@dideu.com China 9602 58
Hu Bei Jiutian Bio-medical Technology CO.,Ltd
027-88013699 17354350817 Ryan@jiutian-bio.com China 7433 58
Shanghai Chaolan Chemical Technology Center QQ:65489617 15618227136 info@SuperLan-chem.com China 8944 58
thiopropazate 4-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-1-piperazineethanol=acetate Acetic acid 2-[4-[3-(2-chloro--10H-phenothiazin-10-yl)propyl]-1-piperazinyl]ethyl Acetic acid 2-[4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-1-piperazinyl]ethyl ester Dartal Dartalan 1-Piperazineethanol, 4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-, 1-acetate hiopropazate 84-06-0