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laudanosine

laudanosine structure

CAS No.: 2688-77-9

Chemical Name:: laudanosine

Synonyms: Nsc 35045;Einecs 220-253-2;(+)-(S)-Laudanosine;Cisatracurium Besylate Impurity 49;(S)-1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline;(1S)-1,2,3,4-Tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methylisoquinoline;[1S,(+)]-1-[(3,4-Dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquinoline;Isoquinoline, 1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-, (1S)-

CBNumber:: CB7897724

Molecular Formula:: C21H27NO4

Molecular Weight:: 357.44

MDL Number:: MFCD27978049

MOL File:: 2688-77-9.mol

Last updated:2023-06-08 09:02:58

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laudanosine Properties

Melting point	89°
alpha	D16 +106° (c = 1.6 in 97% alc); D16 +130° (chloroform); D22 +52.2 ±1.3° (chloroform); D20 +82.5° (ethanol)
Boiling point	490.07°C (rough estimate)
Density	1.1729 (rough estimate)
refractive index	1.5614 (estimate)
storage temp.	-20°C Freezer
solubility	Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly, Sonicated)
form	White to Pale Beige
pka	7.80±0.40(Predicted)
FDA UNII	DA7R5WVN48

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Danger

NFPA 704

	0
4		0

laudanosine price More Price(6)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	27170	(S)-Laudanosine	2688-77-9	1mg	$68	2024-03-01	Buy
Cayman Chemical	27170	(S)-Laudanosine	2688-77-9	5mg	$319	2024-03-01	Buy
TRC	L178525	(S)-Laudanosine	2688-77-9	50mg	$1695	2021-12-16	Buy
AK Scientific	4558CA	N-Methyltetrahydropapaverine	2688-77-9	5mg	$452	2021-12-16	Buy
American Custom Chemicals Corporation	MTB0000505	LAUDANOSINE 95.00%	2688-77-9	5MG	$496.9	2021-12-16	Buy

Product number	Packaging	Price	Buy
27170	1mg	$68	Buy
27170	5mg	$319	Buy
L178525	50mg	$1695	Buy
4558CA	5mg	$452	Buy
MTB0000505	5MG	$496.9	Buy

laudanosine Chemical Properties,Uses,Production

Uses

Laudanosine is a metabolite of the neuromuscular-blocking drugs Atracurium (A794500) and Cisatracurium (C496700) with potentially toxic systemic effects. It crosses the blood-brain barrier and may cause excitement and seizure activity.

Definition

ChEBI: Laudanosine is a member of isoquinolines.

Purification Methods

Crystallise these from EtOH. The (±)-picrate crystallises from EtOH with m 177-178o. The (-)-isomer has m 83-85o and

laudanosine Preparation Products And Raw materials

Raw materials

(R)-1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline DL-LAUDANOSINE 1-[(3,4-Dimethoxyphenyl)methyl]-3,4-dihydro-6,7-dimethoxyisoquinoline Formaldehyde

Preparation Products

laudanosine Suppliers

Global( 25)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76
Chemsky (shanghai) International Co.,Ltd	021-50135380	shchemsky@sina.com	China	15421	60
Shanghai TaoSu Biochemical Technology Co., Ltd.	021-33632979	info@tsbiochem.com	China	8073	58
ChemStrong Scientific Co.,Ltd	0755-66853366 13670046396	sales@chem-strong.com	China	17982	56
Shanghai Xiang Xin Industrial Co., Ltd.	021-50211651 13651607026	sales@xxgmpharm.com	China	487	58
Shanghai Hongye Biotechnology Co. Ltd	400-9205774	sales@glpbio.cn	China	6870	58
Shenzhen Polymeri Biochemical Technology Co., Ltd.	+86-400-002-6226 13028896684	sales@rrkchem.com	China	55717	58
Hubei Moco Chemical Co., Ltd.	18627756402	3001051413@qq.com	China	10009	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
Shenzhen ruikai de biotechnology co., ltd.	0755-61348847 17820674378	2682116078@qq.com	China	7844	58

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Chemsky (shanghai) International Co.,Ltd	60
Shanghai TaoSu Biochemical Technology Co., Ltd.	58
ChemStrong Scientific Co.,Ltd	56
Shanghai Xiang Xin Industrial Co., Ltd.	58
Shanghai Hongye Biotechnology Co. Ltd	58
Shenzhen Polymeri Biochemical Technology Co., Ltd.	58
Hubei Moco Chemical Co., Ltd.	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	58
Shenzhen ruikai de biotechnology co., ltd.	58

2688-77-9(laudanosine )Related Search:

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Atracurium Impurity 24 1-(3,4-dimethoxy-benzyl)-7,8-dimethoxy-1,2,3,4-tetrahydro-isoquinoline Atracurium Impurity 37 Besylate

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Nsc 35045 (+)-(S)-Laudanosine (1S)-1,2,3,4-Tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methylisoquinoline [1S,(+)]-1-[(3,4-Dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquinoline Einecs 220-253-2 Isoquinoline, 1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-, (1S)- (S)-1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline Cisatracurium Besylate Impurity 49 2688-77-9 Alkaloids Aromatics Chiral Reagents Heterocycles Intermediates & Fine Chemicals Metabolites & Impurities Pharmaceuticals Aromatics, Chiral Reagents, Heterocycles, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals