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3-methyl-2-[4-(4-chlorophenyl)-2-thiazolyl]hydrazone,cyclopentanone,hydrobromide

CAS No.
2321332-57-2
Chemical Name:
3-methyl-2-[4-(4-chlorophenyl)-2-thiazolyl]hydrazone,cyclopentanone,hydrobromide
Synonyms
3-methyl-2-[4-(4-chlorophenyl)-2-thiazolyl]hydrazone,cyclopentanone,hydrobromide;Cyclopentanone, 3-methyl-, 2-[4-(4-chlorophenyl)-2-thiazolyl]hydrazone, hydrobromide (1:1)
CBNumber:
CB79043926
Molecular Formula:
Molecular Weight:
386.74
MDL Number:
MOL File:
2321332-57-2.mol
Last updated:2024-10-28 16:48:35

3-methyl-2-[4-(4-chlorophenyl)-2-thiazolyl]hydrazone,cyclopentanone,hydrobromide Properties

solubility DMF: 25 mg/ml; DMSO: 25 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml; Ethanol: 0.5 mg/ml
form A crystalline solid

3-methyl-2-[4-(4-chlorophenyl)-2-thiazolyl]hydrazone,cyclopentanone,hydrobromide price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 19828 CPTH6(hydrobromide) ≥98% 2321332-57-2 1mg $37 2024-03-01 Buy
Cayman Chemical 19828 CPTH6(hydrobromide) ≥98% 2321332-57-2 5mg $161 2024-03-01 Buy
Cayman Chemical 19828 CPTH6 (hydrobromide) ≥98% 2321332-57-2 10mg $283 2024-03-01 Buy
Product number Packaging Price Buy
19828 1mg $37 Buy
19828 5mg $161 Buy
19828 10mg $283 Buy

3-methyl-2-[4-(4-chlorophenyl)-2-thiazolyl]hydrazone,cyclopentanone,hydrobromide Chemical Properties,Uses,Production

Description

CPTH6 is a thiazole derivative that inhibits the lysine acetyltransferase activity of Gcn5 and pCAF but not p300 or CBP.1 It blocks the acetylation of H3/H4 histones and α-tubulin in several leukemia cell lines.1 CPTH6 reduces cell viability, arresting cell cycling in the G0/G1 phase and inducing apoptosis.1 It impairs autophagy in a variety of tumor cell lines, at least in part by altering ATG7-mediated elongation of autophagosomal membranes.2

References

1. Trisciuoglio, D., Ragazzoni, Y., Pelosi, A., et al. CPTH6, a thiazole derivative, induces histone hypoacetylation and apoptosis in human leukemia cells Clin. Cancer Res. 18(2),475-486(2012).
2. Ragazzoni, Y., Desideri, M., Gabellini, C., et al. The thiazole derivative CPTH6 impairs autophagy Cell Death Dis. 4(3),e524(2013).

3-methyl-2-[4-(4-chlorophenyl)-2-thiazolyl]hydrazone,cyclopentanone,hydrobromide Preparation Products And Raw materials

Raw materials

Preparation Products

3-methyl-2-[4-(4-chlorophenyl)-2-thiazolyl]hydrazone,cyclopentanone,hydrobromide Suppliers

Global( 7)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc.
+8613564774135 zijue.cai@tsbiochem.com United States 19881 58
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9806 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11218 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 19699 58

View Lastest Price from 3-methyl-2-[4-(4-chlorophenyl)-2-thiazolyl]hydrazone,cyclopentanone,hydrobromide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
CPTH6 hydrobromide pictures 2024-10-28 CPTH6 hydrobromide
2321332-57-2
US $1850.00-2500.00 / mg 10g TargetMol Chemicals Inc.
3-methyl-2-[4-(4-chlorophenyl)-2-thiazolyl]hydrazone,cyclopentanone,hydrobromide Cyclopentanone, 3-methyl-, 2-[4-(4-chlorophenyl)-2-thiazolyl]hydrazone, hydrobromide (1:1) 2321332-57-2