ChemicalBook >> CAS DataBase List >>(+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile
(+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile
- CAS No.
- 38321-02-7
- Chemical Name:
- (+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile
- Synonyms
- d-Verapamil;Dexverapami;Dexverapamil;Dexverapamil Hydrochloride;[R,(+)]-2-(3,4-Dimethoxyphenyl)-2-isopropyl-5-(N-methyl-3,4-dimethoxyphenethylamino)valeronitrile;(R)-α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)benzeneacetonitrile;(aR)-a-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-benzeneacetonitrile;(αR)-α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl](methyl)amino]propyl]-3,4-dimethoxy-α-(1-methylethyl)benzeneacetonitrile;Benzeneacetonitrile, a-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-, (R)-;Benzeneacetonitrile, α-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)-, (αR)-
- CBNumber:
- CB7941337
- Molecular Formula:
- C27H38N2O4
- Molecular Weight:
- 454.61
- MDL Number:
- MFCD00864679
- MOL File:
- 38321-02-7.mol
Last updated:2023-07-08 08:28:38
Melting point | 129-131°C |
---|---|
Boiling point | 586.1±50.0 °C(Predicted) |
Density | 1.058±0.06 g/cm3(Predicted) |
pka | 8.97±0.50(Predicted) |
FDA UNII | QR5PYD126V |
NCI Drug Dictionary | dexverapamil |
(+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
American Custom Chemicals Corporation | API0000091 | R(+)-VERAPAMIL 95.00% | 38321-02-7 | 1MG | $757.97 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | API0000091 | R(+)-VERAPAMIL 95.00% | 38321-02-7 | 10MG | $2243.59 | 2021-12-16 | Buy |
Medical Isotopes, Inc. | 14156 | (R)-(+)-VerapamilHCl | 38321-02-7 | 5mg | $2400 | 2021-12-16 | Buy |
(+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile Chemical Properties,Uses,Production
Chemical Properties
Off-White Solid
Uses
Both isomers inhibit the p-glycoprotein efflux pump in multidrug resistant tumor cells
Definition
ChEBI: A 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile that has R configuration. It competitively inhibits the multidrug resistance efflux pump P-glycoprotein (MDR-1, EC 3.6.3.44), thereby p tentially increasing the effectiveness of a wide range of antineoplastic drugs which are inactivated by MDR-1 mechanisms. Dexverapamil exhibits lower calcium antagonistic activity and toxicity than racemic verapamil.
Synthesis of (+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile from N-Methylhomoveratrylamine and Benzeneacetonitrile, α-(3-chloropropyl)-3,4-dimethoxy-α-(1-methylethyl)-, (αR)-
(+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
(+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile Suppliers
Global( 12)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2127 | 70 |
Clearsynth Labs Limited | +91-22-26355700 | info@clearsynth.com | India | 9685 | 58 |
Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
QUALITY CONTROL SOLUTIONS LTD. | 13670046396 | ORDERS@QCSRM.COM | China | 18899 | 58 |
Changzhou Bojia Biomedical Technology Co., Ltd. | 2122619822 | czbjpharma@126.com | China | 18488 | 58 |
TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 16377 | 58 |
Supplier | Advantage |
---|---|
LGM Pharma | 70 |
Clearsynth Labs Limited | 58 |
Energy Chemical | 58 |
QUALITY CONTROL SOLUTIONS LTD. | 58 |
Changzhou Bojia Biomedical Technology Co., Ltd. | 58 |
TargetMol Chemicals Inc. | 58 |
38321-02-7((+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile)Related Search:
(+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile
2-(4-Methoxyphenyl)-2-methylpropanenitrile
Devapamil
(+/-)-Verapamil hydrochloride
METHOXY-(-)-VERAPAMIL HYDROCHLORIDE
R(+)-VERAPAMIL HYDROCHLORIDE
3-Methyl-2-(3,4-dimethoxyphenyl)butyronitrile
4-HYDROXY-3-METHOXYPHENYLACETONITRILE
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Dexverapamil
(aR)-a-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-benzeneacetonitrile
Dexverapami
Benzeneacetonitrile, a-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-, (aR)- (9CI)
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d-Verapamil
(aR)-a-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-benzeneacetonitrile Hydrochloride
Dexverapamil Hydrochloride
(R)-α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)benzeneacetonitrile
(αR)-α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl](methyl)amino]propyl]-3,4-dimethoxy-α-(1-methylethyl)benzeneacetonitrile
[R,(+)]-2-(3,4-Dimethoxyphenyl)-2-isopropyl-5-(N-methyl-3,4-dimethoxyphenethylamino)valeronitrile
Benzeneacetonitrile, α-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)-, (αR)-
38321-02-7
C27H39ClN2O4
Intermediates & Fine Chemicals
Pharmaceuticals