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SBC-115337

SBC-115337 Structure
SBC-115337 structure
CAS No.
423148-46-3
Chemical Name:
SBC-115337
Synonyms
SBC-115337;N-(4-((4-(Benzo[d]oxazol-2-yl)phenyl)carbamoyl)phenyl)benzofuran-2-carboxamide;2-Benzofurancarboxamide, N-[4-[[[4-(2-benzoxazolyl)phenyl]amino]carbonyl]phenyl]-;SBC115337,Serine endopeptidases,benzofuran,LDLR,Threonine proteases,SBC-115337,Ser/Thr Protease,inhibit,Inhibitor,recombinant,potent,DiI-LDL,SBC 115337,Serine proteases,HepG2
CBNumber:
CB79728610
Molecular Formula:
C29H19N3O4
Molecular Weight:
473.48
MDL Number:
MFCD02210564
MOL File:
423148-46-3.mol
Last updated:2023-09-04 16:42:00
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SBC-115337 Properties

Boiling point 539.4±40.0 °C(Predicted)
Density 1.394±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
pka 12.36±0.70(Predicted)

SBC-115337 Chemical Properties,Uses,Production

Biological Activity

SBC-115337, as a potent benzofuran compound, is a PCSK9 inhibitor with an IC50 value of 0.5 μM[1][2]. The potent compound (SBC-115,337) shows an IC50 of 0.6 μM measured in an in vitro ELISA assay to monitor the effect of PCSK9 binding to the recombinant LDLR. SBC-115,337 at 1.2 μM induces more than tenfold upregulation of LDLR in HepG2 cells with respect to the control, increases uptake of fluorescently labeled DiI-LDL and loweres LDL-c levels in mice fed a high-fat diet[2].

References

[1]. Xu S, et al. Small molecules as inhibitors of PCSK9: Current status and future challenges. Eur J Med Chem. 2019;162:212-233. [2]. Lavecchia A, et al. Recent advances in developing PCSK9 inhibitors for lipid-lowering therapy. Future Med Chem. 2019;11(5):423-441.

SBC-115337 Preparation Products And Raw materials

Raw materials

Preparation Products

SBC-115337 Suppliers

Global( 5)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 support@targetmol.com United States 19973 58
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 3552 55
Bide Pharmatech Ltd. 400-1647117 15221909166 product02@bidepharm.com China 63720 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24017 58
RD International Technology Co., Limited 18024082417 market@ubiochem.com China 9168 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Tianjin Kailiqi Biotechnology Co., Ltd. 55
Bide Pharmatech Ltd. 58
TargetMol Chemicals Inc. 58
RD International Technology Co., Limited 58

SBC-115337 Spectrum

SBC-115337(423148-46-3)1HNMR
SBC-115337 SBC115337,Serine endopeptidases,benzofuran,LDLR,Threonine proteases,SBC-115337,Ser/Thr Protease,inhibit,Inhibitor,recombinant,potent,DiI-LDL,SBC 115337,Serine proteases,HepG2 2-Benzofurancarboxamide, N-[4-[[[4-(2-benzoxazolyl)phenyl]amino]carbonyl]phenyl]- N-(4-((4-(Benzo[d]oxazol-2-yl)phenyl)carbamoyl)phenyl)benzofuran-2-carboxamide 423148-46-3