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Indiplon

CAS No.
325715-02-4
Chemical Name:
Indiplon
Synonyms
CS-779;INDIPLON;Nbi 34060;CL 285,489);Unii-8bt63da42e;Indiplon (NBI 34060;AcetaMide,N-Methyl-N-[3-[3-(2-thienylcarbonyl)pyrazolo[1,5-a]pyr;N-Methyl-N-[3-[3-[2-thienylcarbonyl]pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]acetamide;N-Methyl-N-[3-[3-(thien-2-ylcarbonyl)pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]acetamide;N-methyl-N-[3-[3-(thiophene-2-carbonyl)pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]acetamide
CBNumber:
CB81011304
Molecular Formula:
C20H16N4O2S
Molecular Weight:
376.43
MDL Number:
MFCD09264193
MOL File:
325715-02-4.mol
MSDS File:
SDS
Last updated:2024-03-26 14:13:49

Indiplon Properties

Melting point >192oC (dec.)
Density 1.35±0.1 g/cm3(Predicted)
storage temp. Store at +4°C
solubility Chloroform (Slightly), Ethyl Acetate (Slightly, Heated)
pka -1.42±0.50(Predicted)
form Solid
color Light Yellow to Dark Yellow
FDA UNII 8BT63DA42E

Indiplon price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 11638 Indiplon ≥95% 325715-02-4 5mg $72 2024-03-01 Buy
Cayman Chemical 11638 Indiplon ≥95% 325715-02-4 10mg $135 2024-03-01 Buy
Cayman Chemical 11638 Indiplon ≥95% 325715-02-4 50mg $530 2024-03-01 Buy
Usbiological 255509 Indiplon 325715-02-4 10mg $403 2021-12-16 Buy
TRC I527200 Indiplon 325715-02-4 2.5mg $80 2021-12-16 Buy
Product number Packaging Price Buy
11638 5mg $72 Buy
11638 10mg $135 Buy
11638 50mg $530 Buy
255509 10mg $403 Buy
I527200 2.5mg $80 Buy

Indiplon Chemical Properties,Uses,Production

Description

Indiplon is a pyrazolopyrimidine that acts as a high-affinity positive allosteric modulator of the GABAA receptor, potentiating GABA-activated chloride currents in a dose-dependent and reversible manner. Indiplon is selective for α1 subunits (EC50 = 2.6 nM) as compared with α2, α3, or α5 (EC50 = 24, 60, and 77 nM). Through this action, indiplon has sedative and hypnotic effects that can improve sleep onset, maintenance, and duration.

Uses

Indiplon is a member of pyrimidines with sedative, hypnotic. Indiplon has been used in trials studying the treatment of Insomnia and Depression.

Definition

ChEBI: Indiplon is a member of pyrimidines.

Biological Activity

Potent GABA A receptor positive allosteric modulator that acts at the benzodiazepine site (K i values are 1.2 and 1.7 nM in rat frontal cortex and cerebellum respectively). Displays ~ 10-fold selectivity for α 1 subunit-containing receptors (EC 50 values are 2.6, 24, 60 and 77 nM for α 1 β 2 γ 2, α 2 β 2 γ 2, α 3 β 3 γ 2 and α 5 β 2 γ 2 receptors respectively). Exhibits sedative, hypnotic, anxiolytic and anticonvulsant activity in vivo and is orally active.

Clinical Use

Indiplon is a novel sedative-hypnotic recently approved for the treatment of insomnia. Like other non-benzodiazepine hypnotics, its mechanism of action is to modulate subunits, especially the alpha-1 subunit, of the GABA receptor complex in order to induce sedation. Indiplon was developed in two different formulations to address two different types of insomnia complaint: indiplon-IR (immediate release) was designed for sleep onset difficulties, while indiplon-MR (modified release) was developed for sleep maintenance insomnia.

Mode of action

Indiplon is a nonbenzodiazepine sedative/hypnotic that is relatively new to the marketplace. It is currently undergoing clinical trials and has been under consideration by the FDA. Caldwell et al. (2009) indicated that indiplon is chemically similar in structure to zaleplon and has a half-life of approximately 1.5 h. Indiplon, which is said to work by enhancing the action of the inhibitory neurotransmitter, y-Aminobutyric acid(GABA), is like most other nonbenzodiazepine sedatives. lt is being produced in a modified release formula that will extend its half-life to aid in sleep maintenance (Ebert et al.2006).An indiplon immediate-release version targets sleep onset insomnia, whereas a modified-release form addresses sleep maintenance insomnia. Both forms of indiplon have shown improvement compared with a placebo in patients with primary insomnia in various areas of subjective and objective sleep measurements (Lankford and Ancoli-Israel 2007; Marrs 2008).Specifically, improvements in total sleep time, latency to persistent sleep,latency to sleep onset, wake after sleep onset,and sleep quality have been noted in clinical trials.So far, trials evaluating both indiplon immediate-release and modified-release have not identified any major serious adverse effects (Marrs 2008).

Indiplon Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 86)Suppliers
Supplier Tel Email Country ProdList Advantage
Dorne Chemical Technology co. LTD
+86-13583358881 +86-18560316533 Ethan@dornechem.com China 291 58
Shandong Hanjiang Chemical Co., Ltd
+86-0533-2066820 +8618369939125 hanson@sdhanjiang.com China 1527 58
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806 sales@capotchem.com China 29797 60
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32480 60
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29914 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 47465 58
Hubei Ipure Biology Co., Ltd
+8613367258412 ada@ipurechemical.com China 10326 58
AFINE CHEMICALS LIMITED
0571-85134551 info@afinechem.com CHINA 15377 58
Finetech Industry Limited
+86-27-87465837 +8618971612321 info@finetechnology-ind.com China 9589 58

View Lastest Price from Indiplon manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Indiplon pictures 2024-03-29 Indiplon
325715-02-4
US $1.00 / g 1g 99% 100kg Dorne Chemical Technology co. LTD
Indiplon pictures 2024-03-28 Indiplon
325715-02-4
US $0.00 / kg 1kg 0.99 10T Shandong Hanjiang Chemical Co., Ltd
Indiplon pictures 2019-07-06 Indiplon
325715-02-4
US $2.00 / kg 1kg 99% 100kg Career Henan Chemical Co
  • Indiplon pictures
  • Indiplon
    325715-02-4
  • US $1.00 / g
  • 99%
  • Dorne Chemical Technology co. LTD
  • Indiplon pictures
  • Indiplon
    325715-02-4
  • US $0.00 / kg
  • 0.99
  • Shandong Hanjiang Chemical Co., Ltd
  • Indiplon pictures
  • Indiplon
    325715-02-4
  • US $2.00 / kg
  • 99%
  • Career Henan Chemical Co
INDIPLON Acetamide, N-methyl-N-(3-(3-(2-thienylcarbonyl)pyrazolo(1,5-A)pyrimidin-7-yl)phenyl)- Nbi 34060 Unii-8bt63da42e N-Methyl-N-[3-[3-[2-thienylcarbonyl]pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]acetamide AcetaMide,N-Methyl-N-[3-[3-(2-thienylcarbonyl)pyrazolo[1,5-a]pyr N-Methyl-N-[3-[3-(thien-2-ylcarbonyl)pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]acetamide N-methyl-N-[3-[3-(thiophene-2-carbonyl)pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]acetamide CS-779 CL 285,489) Indiplon (NBI 34060 325715-02-4 C20H16N4O2S API Aromatics Intermediates & Fine Chemicals Pharmaceuticals Sulfur & Selenium Compounds