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Axitinib

FDA approved axitinib use of treating advanced kidney cancer
Axitinib
Axitinib structure
CAS No.
319460-85-0
Chemical Name:
Axitinib
Synonyms
10mg;D03218;Inlyta;Axtinib;AXITINIB;AG 013736;AsifTinney;AVERMECTINB;Axitinib API;Axitinib Base
CBNumber:
CB81011728
Molecular Formula:
C22H18N4OS
Formula Weight:
386.47
MOL File:
319460-85-0.mol

Axitinib Properties

Melting point:
213-215°C
Boiling point:
668.9±55.0 °C(Predicted)
Density 
1.4
storage temp. 
-20°C Freezer
solubility 
DMSO: ≥8mg/mL
pka
12.70±0.40(Predicted)
form 
powder
color 
white to tan
InChIKey
RITAVMQDGBJQJZ-FMIVXFBMSA-N
CAS DataBase Reference
319460-85-0(CAS DataBase Reference)
FDA UNII
C9LVQ0YUXG
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07,GHS09
Signal word  Warning
Hazard statements  H302-H400
Precautionary statements  P273
Hazard Codes  Xn,N
Risk Statements  22-50/53
Safety Statements  60-61
RIDADR  UN 3077 9 / PGIII
WGK Germany  3
HS Code  29333990

Axitinib price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PZ0193 Axitinib ≥98% (HPLC) 319460-85-0 5mg $106 2019-12-02 Buy
Cayman Chemical 13813 Axitinib ≥98% 319460-85-0 100mg $118 2018-11-13 Buy
Cayman Chemical 13813 Axitinib ≥98% 319460-85-0 50mg $62 2018-11-13 Buy
Cayman Chemical 13813 Axitinib ≥98% 319460-85-0 500mg $496 2018-11-13 Buy

Axitinib Chemical Properties,Uses,Production

FDA approved axitinib use of treating advanced kidney cancer

January 27, 2012, the FDA approved axitinib for the treatment of advanced kidney cancer (renal cell carcinoma) which other drugs unanswer . Inlyta is manufactured and sold by Pfizer,and is a oral pill taken twice a day.
Renal cell carcinoma is a type of tumor originating from the tubular endothelial cells. Axitinib can prevent certain protein called kinases playing a role in tumor growth and metastasis .
Axitinib is a small molecule tyrosine kinase inhibitor, effective against multiple targets, including VEGF receptors 1, 2 and 3.
Dr. Richard Pazdur, hematology and oncology drugs office director of FDA Drug Evaluation and Research Centre, said: "This is the seven kind of drugs allowed treating metastatic or advanced renal cell carcinoma since 2005 . Overall, during this time ,record level of drug development has dramatically changed the treatment of metastatic renal cell carcinoma paradigm, and offers a variety of treatment options for patients. "
In recent years, the drug has been approved for the treatment of kidney cancer include sorafenib (2005), sunitinib (2006), temsirolimus(2007), everolimus (2009), bevacizumab(2009) and pazopanib(2009).
The above information is edited by the chemicalbook of Tian Ye.

Description

In January 2012, the US FDA approved axitinib (also referred to as AG-013736) for the treatment of advanced renal cell carcinoma (RCC) for patients who have not responded to prior therapy. Axitinib is a pan VEGF inhibitor and functions by binding to the intracellular tyrosine kinase catalytic domain of VEGF leading to blockade of signaling through this angiogenic pathway. Axitinib is50–400 times more potent for VEGF (enzyme Ki and cellular IC50s for VEGF 1, 2, and 3 are ~0.1 nM) than first-generation inhibitors like sorafenib and sunitinib. Axitinib also inhibits c-Kit and PDGFR(α/β) with enzyme Ki's of ~2 nM and was selective when tested against a broad panel of other protein kinases. Axitinib was discovered by a structure-based drug design approach and binds to the kinase domain of VEGF in a DFG-out conformation. Axitinib blocks VEGF-2 phosphorylation up to 7 h postdose in vivo and inhibits endothelial cell proliferation in xenograft tumors implanted in mice. Synthetic routes to axitinib employing a Migita coupling to form the diaryl sulfide and a Heck reaction to install the 2-styrylpyridine moiety have been reported.

Chemical Properties

Off-White Solid

Originator

Pfizer (United States)

Uses

A tyrosine kinase inhibitor; used in cancer therapy.

Uses

Axitinib (AG-013736) is a multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ and c-Kit with IC50 of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM, respectively.

Uses

Axitinib is a multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ and c-Kit with IC50 of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM, respectively.

Uses

Axitinib is a tyrosine kinase inhibitor. Axitinib is used in cancer therapy.

Definition

ChEBI: An indazole substituted at position 3 by a 2-(pyridin-2-yl)vinyl group and at position 6 by a 2-(N-methylaminocarboxy)phenylsulfanyl group. Used for the treatment of advanced renal cell carcinoma after failure of a first line systemic tr atment.

brand name

Inlyta

Axitinib Preparation Products And Raw materials

Raw materials

Preparation Products


Axitinib Suppliers

Global( 260)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Jinan Xinke Pharmaceutical Sci.&Tech. Co.,Ltd.
+8613256107535
haiyan.ma@xinkeyiyao.com CHINA 34 58
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21829 58
Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
+86-10-60279497 sales01@cooperate-pharm.com CHINA 1817 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22626 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24698 60
Anqing Chico Pharmaceutical Co., Ltd.
15380796838
chloewu@chicopharm.cn CHINA 341 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30050 58
Hebei Huanhao Biotechnology Co., Ltd.
86-18932741846 whatsapp +8618932741846
86-0311-83975816 coco@hbhuanhao.com CHINA 810 58
Zhejiang ZETian Fine Chemicals Co. LTD
+86-18957127338
sales@zetchem.com CHINA 2886 58
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 969 58

View Lastest Price from Axitinib manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-12-19 Axitinib
319460-85-0
US $0.00 / KG 100g 99% 10kg/Month Jinan Xinke Pharmaceutical Sci.&Tech. Co.,Ltd.
2019-04-18 Axitinib
319460-85-0
US $10.00 / KG 1KG 99% 10 mt Hebei Guanlang Biotechnology Co., Ltd.
2020-01-16 Axitinib
319460-85-0
US $0.00-0.00 / 公斤 100G 99.0%+ 100 tons Shaanxi Dideu Medichem Co. Ltd

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