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2-Acetylbutyrolactone

CAS No.
517-23-7
Chemical Name:
2-Acetylbutyrolactone
Synonyms
ABL;3-acetyldihydrofuran-2(3H)-one;ABL1;ACETYLBUTYROLACTONE;2-Acetylbutyrolacton;-Acetyl-hydroxybutyricacid;2-Oxo-3-acetyltetrahydrofuran;JTK7;p190;bcr/abl
CBNumber:
CB8101532
Molecular Formula:
C6H8O3
Molecular Weight:
128.13
MDL Number:
MFCD00005394
MOL File:
517-23-7.mol
MSDS File:
SDS
Last updated:2024-03-18 11:47:05

2-Acetylbutyrolactone Properties

Melting point <25 °C
Boiling point 107-108 °C5 mm Hg(lit.)
Density 1.19 g/mL at 25 °C(lit.)
vapor pressure 0.131Pa at 20℃
refractive index n20/D 1.459(lit.)
Flash point >230 °F
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility 200g/l
form Liquid
pka 12.00±0.20(Predicted)
color Clear
Water Solubility 310 g/L (20 ºC)
Merck 14,83
BRN 112676
Stability Stable. Incompatible with strong oxidizing agents, strong bases.
LogP -0.43 at 22℃
CAS DataBase Reference 517-23-7(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII I3D73T5K0Q
NIST Chemistry Reference 2(3H)-Furanone, 3-acetyldihydro-(517-23-7)
EPA Substance Registry System 2(3H)-Furanone, 3-acetyldihydro- (517-23-7)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS08
Signal word  Danger
Hazard statements  H315-H319-H360D
Precautionary statements  P202-P264-P280-P302+P352-P305+P351+P338-P308+P313
Hazard Codes  Xi,T
Risk Statements  36/37/38-61
Safety Statements  26-36-37/39-45-53
WGK Germany  1
RTECS  LU3456000
TSCA  Yes
HS Code  29322980
NFPA 704
1
2 0

2-Acetylbutyrolactone price More Price(29)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich A13409 α-Acetylbutyrolactone ≥99% 517-23-7 100g $41.1 2024-03-01 Buy
Sigma-Aldrich A13409 α-Acetylbutyrolactone ≥99% 517-23-7 500g $45.4 2024-03-01 Buy
Sigma-Aldrich A0608 ABL1 (27-end), active, His-tagged from mouse PRECISIO? Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution 517-23-7 10μG $522 2024-03-01 Buy
Sigma-Aldrich SRP5279 ABL1, active, His tagged human PRECISIO?, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution 153190-62-6 10μG $498 2023-06-20 Buy
TCI Chemical A0681 alpha-Acetyl-gamma-butyrolactone >99.0%(GC) 517-23-7 25g $23 2024-03-01 Buy
Product number Packaging Price Buy
A13409 100g $41.1 Buy
A13409 500g $45.4 Buy
A0608 10μG $522 Buy
SRP5279 10μG $498 Buy
A0681 25g $23 Buy

2-Acetylbutyrolactone Chemical Properties,Uses,Production

Description

It is an important intermediate involved in the synthesis of chemical and pharmaceutical products such as vitamin B, 3,4-substituted pyridine, 5-(2-Hydroxyethyl)-4-methylthiazole. In presence of 2-acetylbutyrolactone, reaction of tert-butyl isocyanide with dialkyl acetylenedicarboxylates leads to the formation of dialkyl (E)-2-{(tert-butylamino)[2-oxo-4,5-dihydro-3(2H)-furanylidene]methyl}-2-butenedioates.1 Moreover, reaction of 2-acetylbutyrolactone with thiosemicarbazide and 3-(2-bromo-acetyl)-chromen-2-one in anhydrous ethanol produced 3-{2-[5-hydroxyl-4-(2-hydroxyl-ethyl)-3-methyl-pyrazol-1-yl]-thiazol-4-yl}-chromen-2-one in good yields.2 In addition, 2-acetylbutyrolactone can also function as the raw material for synthesizing pilocarpine that is a leading therapeutic agent for the treatment of narrow and wide angle glaucoma.3 Besides, this chemical can also act as a fluorogenic reagent in the quantitative spectrofluorometric determination of primary amines, which has been demonstrated to be equally accurate and precise as the officially or other reported methods.4

Reference

  1. Asghari, S.; Mohammadi, L., Reaction of tert-butyl isocyanide and dialkyl acetylenedicarboxylates in the presence of 2-acetylbutyrolactone. Synthesis of functionalized alpha-methylene-gamma-butyrolactones. Tetrahedron Lett. 2006, 47, 4297-4299.
  2. Rao, V. R.; Kumar, P. V., Facile one-pot synthesis of 3-{25-hydroxy-4-(2-hydroxy-ethyl)-3-methyl-pyrazol-1-yl -thiazol-4-yl} -chromen-2-ones via a three-component reaction. Synth. Commun. 2006, 36, 2157-2161.
  3. Horne, D. A.; Fugmann, B.; Yakushijin, K.; Buchi, G., A SYNTHESIS OF PILOCARPINE. J. Org. Chem. 1993, 58, 62-64.
  4. Sabry, S. M., Application of 2-acetylbutyrolactone to spectrofluorinietry: Fluorescence properties of Schiff bases derived from 2-acetylbutyrolactone and spectrofluorimetric determination of primary amine-containing compounds. J. Pharm. Biomed. Anal. 2006, 40, 1057-1067.

Chemical Properties

Colorless to light yellow liqui

Uses

An intermediate in the synthesis of 2,4-disubstituted pyridines. A fluorogenic reagent for the spectrofluorimetric determination of primary amines.

Uses

In synthesis of 3,4-disubstituted pyridines; of 5-(b-hydroxethyl)-4-methylthiazole.

Definition

ChEBI: 3-Acetyldihydro-2(3H)-furanone is a gamma-lactone.

Flammability and Explosibility

Not classified

96-48-0
79-20-9
517-23-7
Synthesis of 2-Acetylbutyrolactone from Gamma Butyrolactone and Methyl acetate
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View Lastest Price from 2-Acetylbutyrolactone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
α-Acetyl-γ-butyrolactone pictures 2024-03-19 α-Acetyl-γ-butyrolactone
517-23-7
US $23.00 / KG 1KG 99% 1000 TONS BLiT (Hefei)Chemical Co.,Ltd
2-Acetylbutyrolactone pictures 2024-03-19 2-Acetylbutyrolactone
517-23-7
US $0.00 / kg 1kg 99% 5000mt Jinan Finer Chemical Co., Ltd
a-Acetobutyrolactone pictures 2024-03-08 a-Acetobutyrolactone
517-23-7
US $10.00 / kg 1kg 99% 1000kg Nantong Guangyuan Chemicl Co,Ltd
-(-2-Hydroxyethyl)acetoaceticacid-lactone 2-Acetyl-4-hydroxybutyric acid gamma-lactone alpha-(2-Hydroxyethyl)acetoacetic acid gamma-lactone alpha-Acetobutyrolactone alpha-Acetylbutyrolactone alpha-Acetyl-gamma-hydroxybutyric acid gamma-lactone 2-ACETYL-GAMA-BUTYROLACTONE 2-ACETYL-GAMMA-BUTYROLACTONE 2-ACETYLBUTYROLACTONE 2-ACETYL-4-BUTANOLIDE 2-ACETOBUTANOATE-4-LACTONE AKOS BBS-00004292 AKOS NCG-0049 ALPHA-ACETYL-GAMMA-BUTYROLACTONE ALPHA-ACETYL-GAMMA-HYDROXYBUTYRIC ACID LACTONE 3-Acetyloxolane-2-one 3-acetyl-dihydro-2(3h)-furanone 3-ACETYL-DIHYDRO-FURAN-2-ONE OMEGA-ACETYL-GAMMA-BUTYROLACTONE 2-acetyl-4-butyrolactone 2-Acetyl-gaMMa-butyrolactone for synthesis 3-Acetotetrahydrofuranone-2 NSC 2019 α-Acetyl-γ-hydroxybutyric Acid γ-Lactone 2-AcetylbutyrolaCLone 2-ACETYL-G-BUTYROLACTONE FOR SYNTHESIS The2- acetyl-butyrolactone α-Acetylbutyrolactone, 98%+ Anti-Abl-interactor protein 1 Anti-eps8 binding Anti-interactor protein AblBP4 Anti-Nap1 binding protein NAP1BP Anti-spectrin SH3 domain binding protein 1 SSH3BP1 ABL1, active, His tagged human bcr/abl ABL1 (27-end), active, His-tagged from mouse ANTI-C ABL (ABL1)(C-TERMINAL) antibody produced in rabbit Anti-eps8 binding protein Abelson murine leukemia viral oncogene homolog 1 ANTI-PHOSPHO-ABL(Y204) antibody produced in rabbit JTK7 Monoclonal Anti-ABL1 antibody produced in mouse ANTI-PHOSPHO-ABL(Y412) antibody produced in rabbit Anti-Abelson interactor 1 3-Acetyl-2-(3H)-4,-5-dihydrofuranone 3-Acetyl-2(3H)-4,5-dihydrofuranone 3-acetyldihydro-2(3h)-furanon 3-Acetyltetrahydro-2-furanone -Acetobutyrolacton 3-Acetyl-4,5-dihydro-2(3H)-furanone alpha-Acetyl-gama-butyrolactone 2-ACETYLBUTYROLACTONE, 99+% alpha-Acetyl-gamma-butyrolactone, 99+% alpha-Acetyl-gamma-Butyrolacetone 2-Acety1-gamma-butyrolactone 2-ACETYLBUTYROLOCTONE a-Acetyl-y-Butyrolactone 2(3H)-Furanone, 3-acetyldihydro-