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Nonivamide

Description References
Nonivamide
Nonivamide structure
CAS No.
2444-46-4
Chemical Name:
Nonivamide
Synonyms
PAVA;casaicin;NonvaMide;Capasaicn;NON-4-ENE;AH-23491X;NONIVAMIDE;NSC 172795;capscaisin;Capsaicinoid
CBNumber:
CB8103743
Molecular Formula:
C17H27NO3
Formula Weight:
293.4
MOL File:
2444-46-4.mol

Nonivamide Properties

Melting point:
54°C
Boiling point:
200-210 °C(Press: 0.05 Torr)
Density 
1,1 g/cm3
FEMA 
2787 | NONANOYL 4-HYDROXY-3-METHOXYBENZYLAMIDE
Flash point:
190°C
storage temp. 
Sealed in dry,2-8°C
solubility 
methanol: 100 mg/mL, clear to slightly hazy
form 
powder
pka
9.76±0.20(Predicted)
color 
white to off-white
JECFA Number
1599
BRN 
2144300
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
RGOVYLWUIBMPGK-UHFFFAOYSA-N
Substances Added to Food (formerly EAFUS)
NONANOYL 4-HYDROXY-3-METHOXYBENZYLAMIDE
CAS DataBase Reference
2444-46-4(CAS DataBase Reference)
EWG's Food Scores
1
FDA UNII
S846B891OR
EPA Substance Registry System
Nonanamide, N-[(4-hydroxy-3-methoxyphenyl)methyl]- (2444-46-4)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS06,GHS07
Signal word  Warning
Hazard statements  H300-H315-H317-H319-H335
Precautionary statements  P261-P280-P305+P351+P338-P264-P270-P271-P301+P310+P330-P302+P352+P332+P313+P362+P364-P304+P340+P312-P305+P351+P338+P337+P313-P403+P233-P405-P501
Hazard Codes  T,Xi
Risk Statements  25-36/37/38-43
Safety Statements  26-45-37/39-36/37
RIDADR  UN 3462 6.1/PG 2
WGK Germany  3
RTECS  RA5998000
19
HazardClass  6.1
PackingGroup  II
HS Code  29242990

Nonivamide price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich V9130 N-Vanillylnonanamide ≥97%, powder 2444-46-4 1g $57.1 2021-03-22 Buy
Sigma-Aldrich S567868 N-VANILLYLNONANOAMIDE AldrichCPR 2444-46-4 50mg $144 2021-03-22 Buy
TCI Chemical M0900 N-Vanillylnonanamide [=Capsaicin (Synthetic)] >98.0%(HPLC)(N) 2444-46-4 10g $138 2021-03-22 Buy
Cayman Chemical 25328 Nonivamide ≥98% 2444-46-4 5g $98 2021-03-22 Buy
Cayman Chemical 25328 Nonivamide ≥98% 2444-46-4 1g $28 2021-03-22 Buy

Nonivamide Chemical Properties,Uses,Production

Description

Nonivamide is also called pelargonic acid vanillylamide or PAVA. It is a capsaicinoid. Nonivamide, isolated from peppers, is a naturally occurring analog of capsaicin (sc-3577). Similar to capsaicin, nonivamide can activate the TRPV1 receptor, thus, stimulate the firing rate of dopaminergic neurons in the ventral tegmental area of the brain and to increase the expression of the serotonin receptor gene HTR2A. Nonivamide is with lower TRPV1 binding affinity, thus, a reduced pungency (9 200 000 scoville heat units) compared to capsaicin (16 000 000 scoville heat units).
Nonivamide is used in the food production to add a hot sensation to flavoring agents and spice mixtures. It is also used in the sweets and confectionary industries to add hot sensation into products. In pharmaceutical industries, nonivamide is used as a cheaper alternative for capsaicin. Warming or heating ointment of nonivamide is used for temporary relief of pain from conditions such as rheumatism, arthritis, lumbao, muscular aches, sprains and strains, sporting injuries and other conditions where local warmth is beneficial. Finalgon is one of the common product utilizing nonivamide for this purpose. Nonivamide is also used as an incapacitant spray, affecting the assailed person’s eyes, causing intense pain and swelling.

References

[1] https://www.scbt.com/scbt/product/nonivamide-2444-46-4
[2] https://pubchem.ncbi.nlm.nih.gov/compound/N-Vanillylnonanamide#section=Clinical-Trials
[3] https://cot.food.gov.uk/sites/default/files/cot/cotsection.pdf

Description

Nonanoyl-4-hydroxy-3-methoxybenzylamide is odorless with a pungent, burning taste. Synthesized from nonanyl chloride and vanillylamine.

Chemical Properties

n-Nonanyl-4-hydroxy-3-methoxybenzyl-amide is an odorless compound, but has a pungent, burning taste

Chemical Properties

solid

Uses

analgesic (topical), depletes Substance P

Uses

N-Vanillylnonanamide is a synthetic analogue of Capsaicin (175680) with similar bioactivity.

Definition

ChEBI: A capsaicinoid that is the carboxamide resulting from the formal condensation of the amino group of 4-hydroxy-3-methoxybenzylamine with the carboxy group of nonanoic acid. It is the active ingredient in many pepper sprays.

Preparation

From nonanyl chloride and vanillylamine.

Nonivamide Preparation Products And Raw materials

Raw materials

Preparation Products


Nonivamide Suppliers

Global( 437)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shaanxi Dayu Chemical Co., Ltd
0086-29-88643345
info@dayuchemical.com CHINA 21 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6369 58
QINGDAO HONG JIN CHEMCIAL CO.,LTD.
+86 532 83657313
hjt@hong-jin.com CHINA 226 58
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 20012 60
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8909 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679
86-0551-65418697 info@tnjchem.com China 3000 55
Shanxi Naipu Import and Export Co.,Ltd
+8613734021967
kaia@neputrading.com CHINA 1009 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58

View Lastest Price from Nonivamide manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-12-01 Nonivamide
2444-46-4
US $40.70 / Kg/Bag 10g 98%,95%, 60%, 98%,95%, 60% 10000kg Hebei Crovell Biotech Co Ltd
2021-10-16 Nonivamide
2444-46-4
US $10.00 / KG 1KG 99% 20 tons Hebei Zhanyao Biotechnology Co. Ltd
2021-08-31 Nonivamide
2444-46-4
US $10.00 / KG 1KG 99.99% 20 tons/month Wuhan Monad Medicine Tech Co.,LTD

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