1H-Pyrrole-2,5-dione, 1-[2-(2-methoxyphenyl)ethyl]-
![1H-Pyrrole-2,5-dione, 1-[2-(2-methoxyphenyl)ethyl]- Structure](CAS/20210305/GIF/140481-05-6.gif)
- CAS No.
- 140481-05-6
- Chemical Name:
- 1H-Pyrrole-2,5-dione, 1-[2-(2-methoxyphenyl)ethyl]-
- Synonyms
- ALKBH5-IN-5;1H-Pyrrole-2,5-dione, 1-[2-(2-methoxyphenyl)ethyl]-
- CBNumber:
- CB810590908
- Molecular Formula:
- C13H13NO3
- Molecular Weight:
- 231.25
- MDL Number:
- MOL File:
- 140481-05-6.mol
1H-Pyrrole-2,5-dione, 1-[2-(2-methoxyphenyl)ethyl]- Chemical Properties,Uses,Production
Uses
ALKBH5-IN-5 (compound 18l) is an ALKBH5 inhibitor, exhibiting highly selective inhibitory effect on ALKBH5 with an IC50 of 0.62 μM. ALKBH5-IN-5 exerts a strong antiproliferative effect on NB4 cells with an IC50 of 0.63 μM. ALKBH5-IN-5 binds with ALKBH5 with a Kd of 804 nM. ALKBH5-IN-5 directly targets ALKBH5 in cells and alters m6A levels on mRNA, blocks the related downstream signal pathways, promotes differentiation, and induces Apoptosis. ALKBH5-IN-5 exerts excellent in vivo antitumor activity with TGITV values of 66.3%[1].
References
[1] Wu H, et al. Discovery of Covalent and Cell-Active ALKBH5 Inhibitors with Potent Antileukemia Effects In Vivo. Angew Chem Int Ed Engl. 2025 Feb 20:e202424928. DOI:10.1002/anie.202424928
1H-Pyrrole-2,5-dione, 1-[2-(2-methoxyphenyl)ethyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
1H-Pyrrole-2,5-dione, 1-[2-(2-methoxyphenyl)ethyl]- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Chaolan Chemical Technology Center | 021-QQ：65489617 15618227136 | Sales@ATKchemical.com | China | 9985 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 5925 | 58 |
| Shaoguan Qicheng Biotechnology Co., Ltd | 18122215013 | 780229652@qq.com | China | 1293 | 58 |
| Xirui Biotech (Suzhou) Co., Ltd | 15051477682 15851592819; | 3833346036@qq.com | China | 354 | 58 |
