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Quinupristin

Quinupristin
Quinupristin structure
CAS No.
120138-50-3
Chemical Name:
Quinupristin
Synonyms
RP 68888;RP 57669;Antibiotic RP 57669;Quinupristin Mesylate;Quinupristin(RP-57669);Quinupristin Discontinued;4-[4-(DiMethylaMino)-N-Methyl-L-phenylalanine]-5-[(2S,5R)-5-[[[(3S)-1-azabicyclo[2.2.2]oct-3-yl]thio]Methyl]-4-oxo-2-piperidinecarboxylic acid]virginiaMycin S1
CBNumber:
CB81073487
Molecular Formula:
C53H67N9O10S
Formula Weight:
1022.23
MOL File:
120138-50-3.mol

Quinupristin Properties

Melting point:
~200°

Quinupristin price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 19764 Quinupristin (mesylate) ≥98% 1mg $199 2018-11-13 Buy
Cayman Chemical 19764 Quinupristin (mesylate) ≥98% 5mg $647 2018-11-13 Buy

Quinupristin Chemical Properties,Uses,Production

Uses

Semisynthetic depsipeptide type I streptogramin. An antibacterial agent.

Uses

Quinupristin is a semi-synthetic analogue of virginiamycin B (ostreogyrcin B, pristinamycin IA, streptogramin B) formed by a Mannich condensation and elimination to generate an exocyclic methylene alpha to the ketone of the 4-piperidinone. Addition of quinucidinylthiol to the methylene group affords quinupristin. The structural changes provide a more hydrophobic compound with a readily ionisable group for generating a salt. Quinupristin is used commercially in synergistic combination with dalfopristin (30:70). There is little published data on the synthesis, biological or antibiotic activity of quinupristin alone, however the combination product is highly effective, including activity against antibiotic resistant strains.

Uses

Quinupristin is a semi-synthetic analogue of virginiamycin B (ostreogrycin B, pristinamycin IA, streptogramin B) formed by a Mannich condensation and elimination to generate an exocyclic methylene alpha to the ketone of the 4-piperidinone. Addition of quinucidinylthiol to the methylene group affords quinupristin. The structural changes provide a more hydrophobic compound with a readily ionisable group for generating a salt. Quinupristin is used commercially in synergistic combination with dalfopristin (30:70). There is little published data on the synthesis, biological or antibiotic activity of quinupristin alone, however the combination product is highly effective, including activity against antibiotic resistant strains.

Quinupristin Preparation Products And Raw materials

Raw materials

Preparation Products


Quinupristin Suppliers

Global( 18)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409 orders@qcchemical.com United States 8407 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
Chembest Research Laboratories Limited +86(0)21-20908456
+86(0)21-58180499 sales@biochembest.com; market@biochembest.com China 5996 61
Chemsky (shanghai) International Co.,Ltd 021-50135380
shchemsky@sina.com China 15426 60
S.Z. PhyStandard Bio-Tech. Co., Ltd. 18165736994,0755-83727300
+86 755 28094224 rex.liu@phystandard.com;tom.liu@phystandard.com China 5621 50
Nanjing Sunlida Biological Technology Co., Ltd. 025-58378339;025-57798810
025-57019371 sales@sunlidabio.com China 3818 55
ChemStrong Scientific Co.,Ltd 0755 66853366
0755 28363542 sales@chem-strong.com; China 15615 56
Shanghai EFE Biological Technology Co., Ltd. 021-65675885
021-65675885 info@efebio.com China 9933 58
Raw material medicin reagent co.,Ltd 025-57798860
sales@njromanme.com China 4615 58
Novachemistry +44 (0)208 191 7890
+44 (0)203 637 6965 info@novachemistry.com United Kingdom 3797 58

120138-50-3(Quinupristin)Related Search:


  • 4-[4-(DiMethylaMino)-N-Methyl-L-phenylalanine]-5-[(2S,5R)-5-[[[(3S)-1-azabicyclo[2.2.2]oct-3-yl]thio]Methyl]-4-oxo-2-piperidinecarboxylic acid]virginiaMycin S1
  • Antibiotic RP 57669
  • RP 57669
  • RP 68888
  • Quinupristin(RP-57669)
  • Quinupristin Discontinued
  • Quinupristin Mesylate
  • 120138-50-3
  • C53H67N9O10S
  • Amino Acids & Derivatives
  • Aromatics
  • Chiral Reagents
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
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