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Quinupristin

Quinupristin
Quinupristin structure
CAS No.
120138-50-3
Chemical Name:
Quinupristin
Synonyms
RP 68888;RP 57669;Antibiotic RP 57669;Quinupristin Mesylate;Quinupristin(RP-57669);Quinupristin Discontinued;4-[4-(DiMethylaMino)-N-Methyl-L-phenylalanine]-5-[(2S,5R)-5-[[[(3S)-1-azabicyclo[2.2.2]oct-3-yl]thio]Methyl]-4-oxo-2-piperidinecarboxylic acid]virginiaMycin S1;Virginiamycin S1, 4-[4-(dimethylamino)-N-methyl-L-phenylalanine]-5-[(2S,5R)-5-[[[(3S)-1-azabicyclo[2.2.2]oct-3-yl]thio]methyl]-4-oxo-2-piperidinecarboxylic acid]-
CBNumber:
CB81073487
Molecular Formula:
C53H67N9O10S
Formula Weight:
1022.22
MOL File:
120138-50-3.mol

Quinupristin Properties

Melting point:
~200°
FDA UNII
91VAC8654E

Quinupristin price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 19764 Quinupristin (mesylate) ≥98% 120138-50-3 1mg $209 2021-03-22 Buy
Cayman Chemical 19764 Quinupristin (mesylate) ≥98% 120138-50-3 5mg $784 2021-03-22 Buy

Quinupristin Chemical Properties,Uses,Production

Uses

Semisynthetic depsipeptide type I streptogramin. An antibacterial agent.

Uses

Quinupristin is a semi-synthetic analogue of virginiamycin B (ostreogyrcin B, pristinamycin IA, streptogramin B) formed by a Mannich condensation and elimination to generate an exocyclic methylene alpha to the ketone of the 4-piperidinone. Addition of quinucidinylthiol to the methylene group affords quinupristin. The structural changes provide a more hydrophobic compound with a readily ionisable group for generating a salt. Quinupristin is used commercially in synergistic combination with dalfopristin (30:70). There is little published data on the synthesis, biological or antibiotic activity of quinupristin alone, however the combination product is highly effective, including activity against antibiotic resistant strains.

Uses

Quinupristin is a semi-synthetic analogue of virginiamycin B (ostreogrycin B, pristinamycin IA, streptogramin B) formed by a Mannich condensation and elimination to generate an exocyclic methylene alpha to the ketone of the 4-piperidinone. Addition of quinucidinylthiol to the methylene group affords quinupristin. The structural changes provide a more hydrophobic compound with a readily ionisable group for generating a salt. Quinupristin is used commercially in synergistic combination with dalfopristin (30:70). There is little published data on the synthesis, biological or antibiotic activity of quinupristin alone, however the combination product is highly effective, including activity against antibiotic resistant strains.

Quinupristin Preparation Products And Raw materials

Raw materials

Preparation Products


Quinupristin Suppliers

Global( 27)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409 orders@qcchemical.com United States 8406 58
Target Molecule Corp
18019718960 781-999-5354
marketing@targetmol.com United States 19232 58
BOC Sciences

joybarbara0901@outlook.com CHINA 19685 58
J & K SCIENTIFIC LTD. 400-666-7788 010-82848833-
86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
Chembest Research Laboratories Limited 021-20908456-
021-58180499 sales@BioChemBest.com China 5948 61
Chemsky (shanghai) International Co.,Ltd 021-50135380
shchemsky@sina.com China 15424 60
Nanjing Sunlida Biological Technology Co., Ltd. 025-57798810-
025-57019371 sales@sunlidabio.com;sales@sunlidabio.com China 3814 55
ChemStrong Scientific Co.,Ltd 15920483169 0755-66853366-
sales@chem-strong.com China 19233 56
Shanghai EFE Biological Technology Co., Ltd. 021-65675885
021-65675885 info@efebio.com China 9923 58
Raw material medicin reagent co.,Ltd 025-57798860
sales@njromanme.com China 4610 58

120138-50-3(Quinupristin)Related Search:


  • 4-[4-(DiMethylaMino)-N-Methyl-L-phenylalanine]-5-[(2S,5R)-5-[[[(3S)-1-azabicyclo[2.2.2]oct-3-yl]thio]Methyl]-4-oxo-2-piperidinecarboxylic acid]virginiaMycin S1
  • Antibiotic RP 57669
  • RP 57669
  • RP 68888
  • Quinupristin(RP-57669)
  • Quinupristin Discontinued
  • Quinupristin Mesylate
  • Virginiamycin S1, 4-[4-(dimethylamino)-N-methyl-L-phenylalanine]-5-[(2S,5R)-5-[[[(3S)-1-azabicyclo[2.2.2]oct-3-yl]thio]methyl]-4-oxo-2-piperidinecarboxylic acid]-
  • 120138-50-3
  • C53H67N9O10S
  • Amino Acids & Derivatives
  • Aromatics
  • Chiral Reagents
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
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