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10-Hydroxy-2-decenoic acid

10-Hydroxy-2-decenoic acid Structure
10-Hydroxy-2-decenoic acid structure
CAS No.
14113-05-4
Chemical Name:
10-Hydroxy-2-decenoic acid
Synonyms
10-HAD;10-HDA;10H2DA;jelly acid;Queenbeeaci;QUEEN BEE ACID;Queen been acid;ROYAL JELLY ACID;hydroxy-decenouc acid;10-HYDROXYDECENOIC ACID
CBNumber:
CB8109967
Molecular Formula:
C10H18O3
Molecular Weight:
186.25
MDL Number:
MFCD00204506
MOL File:
14113-05-4.mol
Last updated:2024-04-12 23:00:59
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10-Hydroxy-2-decenoic acid Properties

Melting point 64.0 to 68.0 °C
Boiling point 339.2±15.0 °C(Predicted)
Density 1.038±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 20 mg/ml
form powder to crystal
pka 4.78±0.10(Predicted)
color White to Almost white
LogP 1.808 (est)
CAS DataBase Reference 14113-05-4(CAS DataBase Reference)
FDA UNII 76B519G7TJ

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
Safety Statements  24/25
HS Code  29181990
NFPA 704
0
2 0

10-Hydroxy-2-decenoic acid price More Price(27)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML3381 10-Hydroxy-trans-2-decenoic acid ≥98% (HPLC) 14113-05-4 10MG $86.5 2024-03-01 Buy
Sigma-Aldrich SML3381 10-Hydroxy-trans-2-decenoic acid ≥98% (HPLC) 14113-05-4 50MG $350 2024-03-01 Buy
Sigma-Aldrich PHL89223 10-Hydroxy-trans-2-decenoic acid phyproof? Reference Substance 14113-05-4 10mg $608 2024-03-01 Buy
TCI Chemical H1337 trans-10-Hydroxy-2-decenoic Acid >97.0%(GC)(T) 14113-05-4 200mg $72 2024-03-01 Buy
TCI Chemical H1337 trans-10-Hydroxy-2-decenoic Acid >97.0%(GC)(T) 14113-05-4 1g $252 2024-03-01 Buy
Product number Packaging Price Buy
SML3381 10MG $86.5 Buy
SML3381 50MG $350 Buy
PHL89223 10mg $608 Buy
H1337 200mg $72 Buy
H1337 1g $252 Buy

10-Hydroxy-2-decenoic acid Chemical Properties,Uses,Production

Description

10-HDA is an unsaturated fatty acid found in royal jelly produced from the hypopharyngeal and mandibular gland secretions of honeybees. 10-HDA has longevity-promoting effects in C. elegans at a concentration of 25 μM. It down-regulates matrix metalloproteinases (MMPs) in rheumatoid arthritis synovial fibroblasts at a concentration of 1.25 nM and inhibits VEGF-induced angiogenesis in HUVECs at 500 μM. 10-HDA also facilitates differentiation of neurons from neural stem/progenitor cells and promotes collagen production by skin fibroblasts at concentrations of 100 μM and 1.5 mM, respectively.

Uses

10-Hydroxy-2-decenoic acid has antiseptic, anti-inflammatory, anti-obesity, anti-aging, preventing bone loss and anti-tumour pharmacological effects, with potential therapeutic effects for postmenopausal osteoporosis, as well as benefiting the human gastrointestinal tract[1-3].

Definition

ChEBI: (E)-10-hydroxydec-2-enoic acid is an omega-hydroxy amino acid that is 2-decenoic acid in which one of the hydrogens attached to the terminal carbon is replaced by a hydroxy group and in which the C=C double bond has E configuration. It is a component of royal jelly. It has a role as an animal metabolite and a geroprotector. It is an alpha,beta-unsaturated monocarboxylic acid, a straight-chain fatty acid, a hydroxy monounsaturated fatty acid and an omega-hydroxy-medium-chain fatty acid.

Biological Activity

10-Hydroxy-2-decenoic acid is an orally available royal jelly component that potently inhibits osteoclastogenesis. It binds to free fatty acid receptor 4 (FFAR4) on osteoclasts which inhibits RANKL (receptor activator of nuclear factor-κB (NF-κB) ligand), thereby attenuating the induction of nuclear factor of activated T cells (NFAT) c1. 10-Hydroxy-2-decenoic acid inhibits bone resorption in ovariectomized mice.
The production of pro-inflammatory cytokines, Interleukin (IL)-8, IL-1β and tumor necrosis factor-alpha (TNF-α) in WiDr cells was modulated by 10-HDA. IL-8 were dramatically declined by 10-HDA at 3 mM, while IL-1β and TNF-α were significantly decreased. 10-HDA increased IL-1ra in a dose manner. NF-κB pathway is primarily in response to prototypical pro-inflammatory cytokines, and NF-κB was reduced after 10-HDA treatment. 10-HDA acted as potent bactericide against animal- or human-specific pathogens, including Staphylococcus aureus, Streptococcus alactolyticus, Staphylococcus intermedius B, Staphylococcus xylosus, Salmonella cholearasuis, Vibro parahaemolyticus and Escherichia coli (hemolytic)[1].

References

[1] YUAN-CHANG YANG. 10-hydroxy-2-decenoic acid of royal jelly exhibits bactericide and anti-inflammatory activity in human colon cancer cells.[J]. BMC Complementary and Alternative Medicine, 2018: 202. DOI:10.1186/s12906-018-2267-9.
[2] YOKO HONDA. 10-Hydroxy-2-decenoic Acid, the Major Lipid Component of Royal Jelly, Extends the Lifespan of Caenorhabditis elegans through Dietary Restriction and Target of Rapamycin Signaling.[J]. Journal of Aging Research, 2015, 2015: 425261. DOI:10.1155/2015/425261.
[3] YOSUKE TSUCHIYA. The key royal jelly component 10-hydroxy-2-decenoic acid protects against bone loss by inhibiting NF-κB signaling downstream of FFAR4.[J]. The Journal of Biological Chemistry, 2020, 295 34: 12224-12232. DOI:10.1074/jbc.RA120.013821.

10-Hydroxy-2-decenoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

10-Hydroxy-2-decenoic acid Suppliers

Global( 370)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Mojin Biotechnology Co., Ltd 		+8613288715578 sales@hbmojin.com China 12456 58
WEIFANG OUCHEM TRADE CO.,LTD. 		+86-18506360988 +86-18506360988 wtaili@ouchem.cn China 44 58
Hebei Saisier Technology Co., LTD 		+86-18400010335 +86-13102810335 admin@hbsaisier.cn China 747 58
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 15928 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21691 55
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9348 55
Shanghai Zheyan Biotech Co., Ltd. 		18017610038 zheyansh@163.com CHINA 3620 58
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Chengdu GLP biotechnology Co Ltd 		028-87075086 13350802083 scglp@glp-china.com CHINA 1824 58
Chengdu Biopurify Phytochemicals Ltd. 		+8618080483897 sales@biopurify.com China 3424 58
Supplier Advantage
Hebei Mojin Biotechnology Co., Ltd 		58
WEIFANG OUCHEM TRADE CO.,LTD. 		58
Hebei Saisier Technology Co., LTD 		58
Shanghai Daken Advanced Materials Co.,Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
Hangzhou FandaChem Co.,Ltd. 		55
Shanghai Zheyan Biotech Co., Ltd. 		58
career henan chemical co 		58
Chengdu GLP biotechnology Co Ltd 		58
Chengdu Biopurify Phytochemicals Ltd. 		58

View Lastest Price from 10-Hydroxy-2-decenoic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
10-Hydroxy-2-decenoic acid pictures 2024-04-13 10-Hydroxy-2-decenoic acid
14113-05-4
 US $6.00 / KG 1KG More than 99% 2000KG/Month Hebei Saisier Technology Co., LTD
10-Hydroxy-2-Decenoic Acid pictures 2024-01-17 10-Hydroxy-2-Decenoic Acid
14113-05-4
 US $0.00-0.00 / kg 1kg 98% Min. 500kg WEIFANG OUCHEM TRADE CO.,LTD.
10-Hydroxy-2-decenoic acid pictures 2023-12-29 10-Hydroxy-2-decenoic acid
14113-05-4
 US $0.00 / kg 1kg 99% 1000000 Hebei Jingbo New Material Technology Co., Ltd

10-Hydroxy-2-decenoic acid Spectrum

10-Hydroxy-2-decenoic acid(14113-05-4)MS10-Hydroxy-2-decenoic acid(14113-05-4)1HNMR10-Hydroxy-2-decenoic acid(14113-05-4)13CNMR10-Hydroxy-2-decenoic acid(14113-05-4)IR110-Hydroxy-2-decenoic acid(14113-05-4)IR2

14113-05-4(10-Hydroxy-2-decenoic acid )Related Search:

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Glycolic acid Docosahexaenoic Acid Arachidonic acid 9-DECENOIC ACID 4-Ethyl-4,10-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
2,3,4-Trihydroxybenzoic acid CHLOROPHOSPHONAZO III Ascoric Acid DIGITALIN DIGOXIN
Convallatoxol GITOXIN GITOXIGENIN Queen Bee Acid Royal Jelly Acid

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HYDROXY-2-DECENOIC ACID, (E)-10-(10-HDA)(P) hydroxy-decenouc acid jelly acid trans-10-Hydroxy-2-decenoic Acid (E)-10-hydroxydec-2-enoic acid Queen been acid 10-HAD,10-hydroxydec-2-enoic acid OMEGA-HYDROXY C10:1 (2-TRANS) ROYAL JELLY ACID QUEEN BEE ACID (E)-10-HYDROXY-2-DECENOIC ACID HYDROXY-2-DECENOIC ACID, (E)-10- 10-Hydroxydecylenic acid ω-Hydroxy-Δ2-decenoic acid 10-HYDROXYDECENOIC ACID 10-HYDROXY-2-(E)-DECENOIC ACID 10-HYDROXY-2TR-DECENOIC ACID 10-HAD 10-HDA 10-HYDROXY-2-DECENOIC ACID (10-HAD) 10-Hydroxy-2tr-Decenoic?Acid?(Royal?Jelly?Acid)? 10-HYDROXY-2-DECENOIC ACID (10HDA) HYDROXY-2-DECENOIC ACID, (E)-10-(10-HDA)(SH) 10-Hydroxy-2-decenoic acid (E)-10-Hydroxy-2-decenoic acid, 98%, from honey Royal Jelly acid (Queen Bee Acid) 2-Hydroxy-2-decanoic acid 10-Hydroxy trans-2-decenoic acid trans-10-Hydroxy-2-decenoic Acid > 10H2DA 2-Decenoic acid, 10-hydroxy-, (2E)- 10-Hydroxy-2-decenoic acid USP/EP/BP 10-hydroxydec-2-enoic acid 10-HAD 10-Hydroxy-2-decenoic acidQ: What is 10-Hydroxy-2-decenoic acid Q: What is the CAS Number of 10-Hydroxy-2-decenoic acid Q: What is the storage condition of 10-Hydroxy-2-decenoic acid Queenbeeaci (2E)-10-Hydroxy-2-decenoic acid(10-HAD) HYDROXY-2-DECENOIC ACID, (E)-(10-HDA) Royal jelly acid / 10-hydroxy-2-decenoic acid 14113-05-4 14113-05-4.765-01-5 765-01-5;14113-05-4 765-01-5;14113- HOCH2CH26CHCHCOOH 1