Arachidonic acid
- CAS No.
- 506-32-1
- Chemical Name:
- Arachidonic acid
- Synonyms
- ARA;Arachidonate;Arachidonic;5,8,11,14-EICOSATETRAENOIC ACID;icosa-5,8,11,14-tetraenoic acid;Arachidonic Acid (peroxide free);(5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenoic acid;20:4n-6;CIS-5,8,11,14-EICOSATETRAENOIC ACID;Single-Use Arachidonic Acid (peroxide free)
- CBNumber:
- CB8112259
- Molecular Formula:
- C20H32O2
- Molecular Weight:
- 304.47
- MDL Number:
- MFCD00004417
- MOL File:
- 506-32-1.mol
- MSDS File:
- SDS
| Melting point | -49 °C (lit.) |
|---|---|
| Boiling point | 169-171 °C/0.15 mmHg (lit.) |
| Density | 0.922 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | 2-8°C |
| solubility | ethanol: ≥10 mg/mL |
| pka | 4.75±0.10(Predicted) |
| form | oil |
| color | colorless to light yellow |
| Water Solubility | PRACTICALLY INSOLUBLE |
| Merck | 14,765 |
| BRN | 1713889 |
| Concentration | 1 mCi/ml |
| Solvent | Ethanol under argon |
| Specific Activity | 200-240 Ci/mmol |
| Stability | Light Sensitive, Temperature Sensitive |
| InChIKey | YZXBAPSDXZZRGB-DOFZRALJSA-N |
| LogP | 6.99 |
| CAS DataBase Reference | 506-32-1(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 27YG812J1I |
| NIST Chemistry Reference | Arachidonic acid(506-32-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H319 | |||||||||
| Precautionary statements | P210-P233-P240-P241-P242-P305+P351+P338 | |||||||||
| Risk Statements | 19 | |||||||||
| Safety Statements | 24/25-19 | |||||||||
| RIDADR | UN1170 - class 3 - PG 2 - Ethanol | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | CE6675000 | |||||||||
| F | 8-10-23 | |||||||||
| HS Code | 29161900 | |||||||||
| Toxicity | dns-mus:mmr 10 mg/L CRNGDP 5,1123,84 | |||||||||
| NFPA 704 |
|
Arachidonic acid price More Price(59)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A-122 | Arachidonic acid 1.0?mg/mL in ethanol, certified reference material, Cerilliant? | 506-32-1 | 1mL | $191 | 2024-03-01 | Buy |
| Sigma-Aldrich | 181198 | Arachidonic Acid - CAS 506-32-1 - Calbiochem Precursor for prostaglandins, prostacyclin, and thromboxane. | 506-32-1 | 1G | $378 | 2024-03-01 | Buy |
| Sigma-Aldrich | 10931 | Arachidonic acid >95.0% (GC) | 506-32-1 | 250mg | $185 | 2024-03-01 | Buy |
| Sigma-Aldrich | 10931 | Arachidonic acid >95.0% (GC) | 506-32-1 | 1g | $463 | 2024-03-01 | Buy |
| Sigma-Aldrich | SAB1412610 | ANTI-FOXC1 antibody produced in mouse clone 1E11, purified immunoglobulin, buffered aqueous solution | 506-32-1 | 100μg | $503 | 2023-01-07 | Buy |
Arachidonic acid Chemical Properties,Uses,Production
Description
Arachidonic acid belongs to a kind of polyunsaturated omega-6 fatty acid, which is highly biologically relevant. It is abundantly distributed in brain, muscles and liver. It is the precursor for all prostaglandins, thromboxanes, and leukotrienes. Most cellular arachidonic acid is esterified in the membrane phospholipids. It is an important second messenger of cellular signalling participating in the regulation of signaling enzymes including PLC-γ, PLC-δ, and PKC-α, -β, and -γ isoforms. In addition, arachidonic acid acts as key inflammatory intermediate as well as avasodilator. Generally, the body can synthesize the arachidonic acid through linoleic acid. However, upon linoleic acid deficiency, it is necessary to supplement arachidonic acid from the diets. Food sources of arachidonic acid include meat, eggs and some fishes. Alternatively, we can also have arachidonic acid supplements.
References
http://www.fitday.com/fitness-articles/nutrition/healthy-eating/what-is-arachidonic-acid.html
https://en.wikipedia.org/wiki/Arachidonic_acid
https://www.caymanchem.com/product/90010
Description
Arachidonic acid (AA, sometimes ARA) is a polyunsaturated omega-6 fatty acid 20:4(ω-6). It is the counterpart to the saturated arachidic acid found in peanut oil, (L. arachis – peanut.).
Chemical Properties
In chemical structure, arachidonic acid is a carboxylic acid with a 20-carbon chain and four cis-double bonds; the first double bond is located at the sixth carbon from the omega end.
Some chemistry sources define 'arachidonic acid' to designate any of the eicosatetraenoic acids. However, almost all writings in biology, medicine and nutrition limit the term to all-cis-5,8,11,14- eicosatetraenoic acid.
Chemical Properties
liquid
Uses
arachidonic acid is an ingredient with skin-smoothing, emollient, and healing properties. Arachidonic acid is an omega-6 essential fatty acid naturally occurring in the skin and considered critical for appropriate skin metabolism. It is a constituent of vitamin F.
Uses
An unsaturated omega-6 fatty acid constituent of the phospholipids of cell membranes
Uses
Arachidonic Acid is an essential fatty acid and a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes. Arachidonic Acid occurs in liver, brain, glandular organs, and depot fats of animals, in small amounts in human depot fats, and Arachidonic Acid is also a constituent of animal phosphatides.
Definition
ChEBI: A long-chain fatty acid that is a C20, polyunsaturated fatty acid having four (Z)-double bonds at positions 5, 8, 11 and 14.
General Description
A Certified Spiking Solution? suitable for use in mass spectrometry-based fatty acid testing applications such as assessment of cardiovascular disease risk and fatty acid deficiency, and detection and quantification of arachidonic acid in nutraceuticals and dietary supplements. Arachidonic acid (cis-5,8,11,14), sometimes referred to as AA or ARA, is a polyunsaturated omega-6 fatty acid. Studies suggests that ARA as well as other fatty acids can serve as biomarkers for cardiovascular disease, and nutritional and metabolic disorders.
Biological Activity
Endogenous free fatty acid released from phospholipids by phospholipase A 2 . Important cellular signaling mediator and precursor of eicosanoids. Metabolized by lipoxygenases, cyclooxygenases and cytochrome P450 monooxygenases.
Biochem/physiol Actions
Arachidonic acid stimulates adhesion of MDA-MB-435 human metastatic cancer cells to extracellular matrix molecules (collagen IV and vitronectin) .
Safety Profile
Poison by intravenous route.Experimental reproductive effects. Mutation datareported. When heated to decomposition it emits acridsmoke and irritating fumes.
Carcinogenicity
In vitro and in vivo studies indicate that inhibition of arachidonic acid metabolism inhibits the growth of malignant cells, including head and neck squamous cell carcinoma, and implicates arachadonic acid in facilitating the metastasis of these tumor cells. Arachidonic acid reaction with cyclooxygenase and lipoxygenases yield eicosanoids that can mediate prostate cancer proliferation and enhance both tumor vascularization and metastasis. Cytochrome P450 arachidonic acid epoxygenases promote cell proliferation and inhibit apoptosis in endothelial cells.
Arachidonic acid Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 | info@konochemical.com | China | 2995 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503259 +86-19930503259 | cherry@crovellbio.com | China | 18456 | 58 |
| Hebei Jingbo New Material Technology Co., Ltd | +8619931165850 | hbjbtech@163.com | China | 1000 | 58 |
| Hangzhou Zelixir Biotech Co., Ltd. | +8618867646786 | neal.chen@zelixir.com | China | 229 | 58 |
| BINBO BIOLOGICAL CO.,LTD | +8618629063126 | info@binbobiological.com | China | 290 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 994 | 58 |
| Wuhan Xinhao Biotechnology Co., Ltd | +86-18120578002 +86-18120578002 | xinhao-6@xinhaoshengwu.com | China | 350 | 58 |
| airuikechemical co., ltd. | +undefined86-15315557071 | sales02@airuikechemical.com | China | 994 | 58 |
| Ouhuang Engineering Materials (Hubei) Co., Ltd | +8617702722807 | admin@hbouhuang.com | China | 2259 | 58 |
Related articles
- The Biological activity of Arachidonic acid
- Arachidonic acid is an essential fatty acid and a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrie....
- Dec 25，2023
View Lastest Price from Arachidonic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-22 | Arachidonic acid
506-32-1
|
US $0.00 / kg | 1kg | 99.8% | 1000 kg | BINBO BIOLOGICAL CO.,LTD | |
 |
2024-04-18 | Arachidonic acid
506-32-1
|
US $6.00 / kg | 1kg | 99.8% | 10000ton | Ouhuang Engineering Materials (Hubei) Co., Ltd | |
 |
2024-04-02 | Arachidonic acid
506-32-1
|
US $0.00-0.00 / kg | 1kg | 99% | 100ton | Wuhan Xinhao Biotechnology Co., Ltd |
-
- Arachidonic acid
506-32-1
- US $0.00 / kg
- 99.8%
- BINBO BIOLOGICAL CO.,LTD
-
- Arachidonic acid
506-32-1
- US $6.00 / kg
- 99.8%
- Ouhuang Engineering Materials (Hubei) Co., Ltd
-
- Arachidonic acid
506-32-1
- US $0.00-0.00 / kg
- 99%
- Wuhan Xinhao Biotechnology Co., Ltd