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Naproxen sodium

CAS No.
26159-34-2
Chemical Name:
Naproxen sodium
Synonyms
aleve;Naprelan;Anax;(S)-6-METHOXY-ALPHA-METHYL-2-NAPHTHALENEACETIC ACID SODIUM SALT;Anaprox;NAPROXEN SODIUM SALT;Duk-F;Flanax;RS-3650;Aflaxen
CBNumber:
CB8114925
Molecular Formula:
C14H13O3.Na
Molecular Weight:
252.24
MDL Number:
MFCD00058507
MOL File:
26159-34-2.mol
MSDS File:
SDS
Last updated:2024-03-15 13:40:56

Naproxen sodium Properties

Melting point 250-251°C
alpha D -11° (in methanol)
storage temp. Inert atmosphere,Room Temperature
solubility Freely soluble in water, freely soluble or soluble in methanol, sparingly soluble in ethanol (96 per cent).
color White to Off-White
Water Solubility Soluble in water up to 100mg/mlSoluble in methanol and chloroform. Slightly soluble in ether. Insoluble in water.
CAS DataBase Reference 26159-34-2(CAS DataBase Reference)
FDA UNII 9TN87S3A3C

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS08
Signal word  Danger
Hazard statements  H302-H360
Precautionary statements  P201-P202-P264-P270-P301+P312-P308+P313
Hazard Codes  Xn,T
Risk Statements  22-61
Safety Statements  53-45
RIDADR  3249
WGK Germany  3
RTECS  QJ1047000
HazardClass  6.1(b)
PackingGroup  III
HS Code  2918992090

Naproxen sodium price More Price(37)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich M1275 Naproxen sodium 98.0-102.0% 26159-34-2 5g $92.7 2024-03-01 Buy
Sigma-Aldrich 1457403 Naproxen sodium United States Pharmacopeia (USP) Reference Standard 26159-34-2 200mg $436 2024-03-01 Buy
Alfa Aesar J63103 Naproxen sodium, 98% 26159-34-2 5g $75.5 2024-03-01 Buy
Alfa Aesar J63103 Naproxen sodium, 98% 26159-34-2 25g $308 2024-03-01 Buy
Sigma-Aldrich N5160 Naproxen sodium meets USP testing specifications 26159-34-2 5g $110 2024-03-01 Buy
Product number Packaging Price Buy
M1275 5g $92.7 Buy
1457403 200mg $436 Buy
J63103 5g $75.5 Buy
J63103 25g $308 Buy
N5160 5g $110 Buy

Naproxen sodium Chemical Properties,Uses,Production

Non-steroidal anti-inflammatory analgesic

Naproxen sodium is a non-steroidal anti-inflammatory analgesic drug which is more tolerable to human, belonging to the phenylpropionic acid compounds. It plays anti-inflammatory effect by inhibiting prostaglandin synthesis.It is absorbed rapidly after oral administration and the plasma reached the peak concentration within 2 to 4 hours. Food has little effect on the rate of absorption. Naproxen and plasma protein are highly binded(99%); the plasma concentration is between 23~40mcg/ml. The metabolic process is demethylation and then combining with glucuronide; the elimination half-life is 12 to 15 hours, mainly excreted by the urine. Clinical application is to relieve a variety of mild to moderate degree of pain, such as tooth extraction and other postoperative pain, primary dysmenorrhea and headache. It is also used for rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, juvenile arthritis, tendinitis, bursitis and acute gouty arthritis; it also plays a role in arthritis pain, swelling and activity restricted symptom. Psoriatic arthritis and Reiter's syndrome can also be treated with this product. Compared with ibuprofen, fenoprofen, aspirin, sulindac and indomethacin, the symptom relief effect was similar, but the incidence and severity of adverse reactions in the gastrointestinal and neurological systems were low. In addition, this product is also the same as aspirin which can inhibit platelet aggregation and prolong bleeding time; but the effect is reversible, and can be restored after stopping.
Naproxen sodium and plasma protein binding rate is high (99%), and other protein-binding drugs can be replaced by its joint out. Therefore, the acceptance of these drugs (such as oral anticoagulants, sulfonylurea, hydantoins) people should observe the interaction effects. At the same time the application of probenecid, naproxen can increase the plasma concentration, half-life period. Magnesium hydroxide, aluminum can make this product absorption rate slightly lower; sodium bicarbonate can make it higher.

Uses

Used as anti-inflammatory analgesic

Chemical Properties

White Powder

Uses

An anti-inflammatory, analgesic, antipyretic. A non-steroidal anti-inflammatory

Uses

Naproxen (Aleve, Anaprox) is a COX inhibitor for COX-1 and COX-2 with IC50 of 8.7 μM and 5.2 μM, respectively

Uses

A cyclooxygenase inhibitorNaproxen sodium acts as a nonselective inhibitor of Cox-1 and Cox-2. It serves as an anti-inflammatory agent with analgesic and antipyretic properties. Further, it is used in the treatment of rheumatoid arthritis and other rheumatic or musculoskeletal disorders, dysmenorrhea and acute gout.

Definition

ChEBI: The sodium salt of naproxen.

brand name

Aleve (Bayer); Anaprox (Roche);Naprelan (Stat Trade).

General Description

Naproxen sodium (NS) is a sodium salt of propionic acid derivative and demonstrates analgesic, anti-pyretic, and anti-inflammatory properties. It exhibits efficiency in being used as an indomethacin in the treatment of acute musculoskeletal disorders. It belongs to the group of nonsteroidal anti-inflammatory drugs (NSAIDS) and acts by inhibiting the activity of both the cyclooxygenase enzymes, COX-1 & COX-2 and further blocking the synthesis of certain prostaglandins. It is administered in the treatment of ankylosing spondylitis, osteoarthritis, rheumatoid disorders, acute gout, mild to moderate pain, tendonitis, bursitis, dysmenorrhea, fever, and migraine headache. Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Biological Activity

Non-selective cyclooxygenase (COX) inhibitor that displays anti-inflammatory, antipyretic and analgesic effects. Has a neuroprotective role against colchicine-induced cognitive impairment and oxidative stress.

Biochem/physiol Actions

Cyclooxygenase (Prostaglandin H synthase 1 and 2) inhibitor.

References

[1]. mendias cl, tatsumi r and allen re. role of cyclooxygenase-1 and -2 in satellite cell proliferation, differentiation, and fusion. muscle nerve, 2004, 30(4):497-500.
[2]. hinz b, cheremina o, besz d, et al. impact of naproxen sodium at over-the-counter doses on cyclooxygenase isoforms in human volunteers. int j clin pharmacol ther, 2008, 46(4):180-6.
[3]. sances g, martignoni e, fioroni l, et al. naproxen sodium in menstrual migraine prophylaxis: a double-blind placebo controlled study. headache, 1990, 30(11):705-9.
[4]. tavolari s, bonafè m, marini m, et al. licofelone, a dual cox/5-lox inhibitor, induces apoptosis in hca-7 colon cancer cells through the mitochondrial pathway independently from its ability to affect the arachidonic acid cascade. carcinogenesis, 2008, 29(2):371-80.

22204-53-1
26159-34-2
Synthesis of Naproxen sodium from Naproxen

Naproxen sodium Preparation Products And Raw materials

Global( 415)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei baicao biology science and technology co., ltd
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Shanghai Affida new material science and technology center
+undefined15081010295 2691956269@qq.com China 349 58
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+86-19930503282 alice@crovellbio.com China 8823 58

View Lastest Price from Naproxen sodium manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Naproxen sodium pictures 2024-03-16 Naproxen sodium
26159-34-2
US $0.00-0.00 / KG 1KG 99 100 mt Shanghai Affida new material science and technology center
Naproxen sodium pictures 2024-03-16 Naproxen sodium
26159-34-2
US $0.00 / KG 100g 98%+ 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Naproxen Sodium pictures 2023-07-25 Naproxen Sodium
26159-34-2
US $50.00 / Kg/Drum 25KG 98.5%-101% 100tons/month Hebei Yanxi Chemical Co., Ltd.
  • Naproxen sodium pictures
  • Naproxen sodium
    26159-34-2
  • US $0.00-0.00 / KG
  • 99
  • Shanghai Affida new material science and technology center
  • Naproxen sodium pictures
  • Naproxen sodium
    26159-34-2
  • US $0.00 / KG
  • 98%+
  • WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
  • Naproxen Sodium pictures
  • Naproxen Sodium
    26159-34-2
  • US $50.00 / Kg/Drum
  • 98.5%-101%
  • Hebei Yanxi Chemical Co., Ltd.

Naproxen sodium Spectrum

6-methoxy-alpha-methyl-,sodiumsalt,(s)-2-naphthaleneaceticaci 6-methoxy-alpha-methyl-,sodiumsalt,l-(-)-2-naphthaleneaceticaci [R,(-)]-6-Methoxy-α-methyl-2-naphthaleneacetic acid sodium salt RS-3650 (2S)-2-(6-Methoxy-2-naphthyl)propanoicacidsodiumsalt Naproxen Sodium (200 mg) sodium (-)-2-(6-methoxy-2-naphthyl)propionate Naproxen sodium USP.CP NAPROXEN, USP 2-Naphthaleneacetic acid, 6-methoxy-.alpha.-methyl-, sodium salt, (.alpha.S)- (s)-6-methoxy-α-methyl-2-naphthaleneacetic acid sodium salt NAPROXENSODIUM,USP Aflaxen Agilxen Anaprox DS Apraxin Apronax Dafloxen Duk-F Flanax Xenobid sodiuM (S)-2-(6-Methoxynaphthalen-2-yl)propanoate Naproxen SodiuM (A) 500 Mg Naproxen (Aleve) UniflaM Synflex Naproxen Base/Sodium (DMF) C14H13NAO3 252.25 apranax l-(-)-6-methoxy-alpha-methyl-2-naphthaleneaceticacidsodiumsalt naprosynsodium sodiumnaprosyn sodiumnaproxen 6-METHOXY-ALPHA-METHYL-2-NAPHTHALENEACETIC ACID SODIUM (S)-6-METHOXY-A-METHYL-2-NAPHTHALENEACETIC ACID, SODIUM SALT (S)-NAPROXEN, SODIUM SALT (-)-SODIUM (S)-6-METHOXY-ALPHA-METHYL-2-NAPHTHALENEACETATE NAPROXEN SODIUM (-)-NAPROXEN SODIUM SALT NAPROXEN SODIUM;NAPRELAN; ANAPROX sodium (2S)-2-(6-methoxy-2-naphthalenyl)propanoate aproxen sodium Miranax 2-Naphthaleneacetic acid, 6-methoxy-a-methyl-, sodium salt, (aS)- Naproxen sodium USP/EP/BP Naproxen Sodium (RS-3650) (S)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid sodium s... (2S)-2-(6-methoxy-2-naphthyl)propanoic acid Naproxen SodiumQ: What is Naproxen Sodium Q: What is the CAS Number of Naproxen Sodium Q: What is the storage condition of Naproxen Sodium Q: What are the applications of Naproxen Sodium Naproxen Sodium (1457403) aleve Anaprox Anax (S)-6-METHOXY-ALPHA-METHYL-2-NAPHTHALENEACETIC ACID SODIUM SALT NAPROXEN SODIUM SALT Naprelan Afobazole Impurity 6 NAPROXEN SODIUM 90% DC GRANULES