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4'-Methylpropiophenone

CAS No.
5337-93-9
Chemical Name:
4'-Methylpropiophenone
Synonyms
4-METHYLPROPIOPHENONE;1-(p-Tolyl)propan-1-one;ETHYL-P-TOLYLKETON;LABOTEST-BB LT00053050;4-Methylpropiophenon;P-METHYLPROPIOPHENONE;P-Methyl phenylethylketone;Ethyl 4-methylphenyl ketone;1-(4-methylphenyl)-propan-1-one;4-Methylpropiophenone wickr bettyml
CBNumber:
CB8116040
Molecular Formula:
C10H12O
Molecular Weight:
148.2
MDL Number:
MFCD00009312
MOL File:
5337-93-9.mol
MSDS File:
SDS
Last updated:2024-03-18 17:23:41

4'-Methylpropiophenone Properties

Melting point 7.2 °C
Boiling point 238-239 °C(lit.)
Density 0.993 g/mL at 25 °C(lit.)
refractive index n20/D 1.528(lit.)
Flash point 229 °F
storage temp. Inert atmosphere,Room Temperature
solubility Soluble in chloroform and hexane.
form Oil
color Colourless
Specific Gravity 0.99
BRN 2042137
InChI InChI=1S/C10H12O/c1-3-10(11)9-6-4-8(2)5-7-9/h4-7H,3H2,1-2H3
InChIKey PATYHUUYADUHQS-UHFFFAOYSA-N
SMILES C(C1=CC=C(C)C=C1)(=O)CC
CAS DataBase Reference 5337-93-9(CAS DataBase Reference)
FDA UNII 8490C17WAB
NIST Chemistry Reference 4'-Methylpropiophenone(5337-93-9)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P301+P312-P302+P352-P304+P340-P305+P351+P338
Safety Statements  24/25
WGK Germany  3
HS Code  29143990
NFPA 704
1
0 0

4'-Methylpropiophenone price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 517925 4′-Methylpropiophenone 90%, technical grade 5337-93-9 100ml $47.34 2024-03-01 Buy
TCI Chemical M0768 4'-Methylpropiophenone >95.0%(GC) 5337-93-9 25mL $40 2024-03-01 Buy
TCI Chemical M0768 4'-Methylpropiophenone >95.0%(GC) 5337-93-9 500mL $287 2024-03-01 Buy
Alfa Aesar B21673 4'-Methylpropiophenone, 94% 5337-93-9 100g $29.65 2024-03-01 Buy
Alfa Aesar B21673 4'-Methylpropiophenone, 94% 5337-93-9 500g $121 2024-03-01 Buy
Product number Packaging Price Buy
517925 100ml $47.34 Buy
M0768 25mL $40 Buy
M0768 500mL $287 Buy
B21673 100g $29.65 Buy
B21673 500g $121 Buy

4'-Methylpropiophenone Chemical Properties,Uses,Production

Chemical Properties

clear light yellow liquid

Uses

4′-Methylpropiophenone is a chemical reagent used in electrocarboxylation reactions.

Uses

4'-methylpropiophenone has been reported to be used in the synthesis of pharmaceutical compounds such as tolperisone and other muscle relaxants. The substance is also a starting material in the synthesis of 4-methylmethcathinone (mephedrone). Mephedrone has been encountered as a ‘legal high’ and on the illicit drug market masquerading as cocaine (in powder form), MDMA (in tablet form) and as an adulterant. According to the 2016 European Drugs Market Report produced by the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA), mephedrone has created a specific demand and carved its own distinct market share.

Application

4′-Methylpropiophenone can be used as a building block to synthesize:
N-(4-Chlorophenyl)-N′-[1-(4-methylphenyl)propyl]urea as a potential CRAC channel inhibitor.
Mono and trinuclear cobaloxime/organocobaloxime complexes, which are used as efficient catalysts for the synthesis of cyclic carbonates.
Tolperisone (TOL) via acid-catalyzed reaction with piperidine hydrochloride and 1,2-dioxolane.

Definition

ChEBI: 4-methylpropiophenone is an aromatic ketone that is propiophenone bearing a methyl group at C-4. It derives from a propiophenone.

Synthesis

4'-Methylpropiophenone can be synthesized through various methods. One common approach involves the reaction of propiophenone with methylmagnesium bromide or methyl lithium in the presence of a catalyst. Another method utilizes Friedel-Crafts acylation, where propiophenone is acylated with methyl chloride or methyl bromide using a Lewis acid catalyst. These methods allow for the controlled introduction of the methyl group onto the phenyl ring.

25574-04-3
5337-93-9
Synthesis of 4'-Methylpropiophenone from 1-(4-METHYLPHENYL)-1-PROPANOL 97

4'-Methylpropiophenone Preparation Products And Raw materials

Global( 530)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Hengmao New Materials Technology CO., LIMITED
+86-0086-1773693-3208 +8617736933208 1137059254@qq.com China 9287 58
Shanghai Worldyang Chemical Co.,Ltd.
,+86-21-56795779; +8613651600618 sales@worldyachem.com China 879 58
Dorne Chemical Technology co. LTD
+8618560316533 Ethan@dornechem.com China 291 58
Lihe Pharm Technology(Wuhan)Co.,Ltd
+8618071517867 info@lihepharma.com China 194 58
Wuhan wingroup Pharmaceutical Co., Ltd
+86-13296627870; +8613296627870 info@whwingroup.com China 703 58
Hebei Anlijie Biotechnology Co., Ltd
+8619031013551 ably@aljbio.com China 177 58
Hebei Mojin Biotechnology Co., Ltd
+86-13288715578 +86-13231137666 sales@hbmojin.com China 12409 58
Taiyuan CJ Trading Co., Ltd
+86-18536636121 anna@lianxuchemical.com China 8 58
Nanjing Deda New Material Technology Co., Ltd
+8613223293093 bella@njdeda.com China 75 58
Hong Kong Excellence Biotechnology Co., Ltd.
+86-86-18838029171 +8618126314766 ada@sh-teruiop.com China 892 58

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View Lastest Price from 4'-Methylpropiophenone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4'-Methylpropiophenone pictures 2024-03-19 4'-Methylpropiophenone
5337-93-9
US $15.00-10.00 / kg 1kg 99.5 10 ton per month Nanjing Deda New Material Technology Co., Ltd
4'-Methylpropiophenone pictures 2024-03-19 4'-Methylpropiophenone
5337-93-9
US $15.00-10.00 / kg 1kg 99.5 10 ton per month Nanjing Deda New Material Technology Co., Ltd
 4-Methylpropiophenone pictures 2024-03-19 4-Methylpropiophenone
5337-93-9
US $50.00-30.00 / kg 1kg 99.9% 20 tons Hebei Dangtong Import and export Co LTD
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