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ChemicalBook >> CAS DataBase List >>(5S,6Z,8E,10E,14Z)-5-hydroxy-12-oxoicosa-6,8,10,14-tetraenoic acid

(5S,6Z,8E,10E,14Z)-5-hydroxy-12-oxoicosa-6,8,10,14-tetraenoic acid

(5S,6Z,8E,10E,14Z)-5-hydroxy-12-oxoicosa-6,8,10,14-tetraenoic acid Structure
(5S,6Z,8E,10E,14Z)-5-hydroxy-12-oxoicosa-6,8,10,14-tetraenoic acid structure
CAS No.
136696-10-1
Chemical Name:
(5S,6Z,8E,10E,14Z)-5-hydroxy-12-oxoicosa-6,8,10,14-tetraenoic acid
Synonyms
12-Oxo-ltb4;12-oxoleukotriene B4;12-Keto-leukotriene B4;12-dehydro-leukotriene B4;SJVWVCVZWMJXOK-NOJHDUNKSA-N;(5S,6Z,8E,10E,14Z)-5-hydroxy-12-oxoicosa-6,8,10,14-tetraenoic acid;6,8,10,14-Eicosatetraenoic acid, 5-hydroxy-12-oxo-, (S-(E,Z,E,Z))-;6,8,10,14-Eicosatetraenoic acid, 5-hydroxy-12-oxo-, (5S,6Z,8E,10E,14Z)-
CBNumber:
CB81235331
Molecular Formula:
C20H30O4
Molecular Weight:
334.45
MDL Number:
MFCD00065854
MOL File:
136696-10-1.mol
Last updated:2023-06-08 09:02:46
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(5S,6Z,8E,10E,14Z)-5-hydroxy-12-oxoicosa-6,8,10,14-tetraenoic acid Properties

Boiling point 524.2±50.0 °C(Predicted)
Density 1.036±0.06 g/cm3(Predicted)
storage temp. Store at -80°C,protect from light
solubility DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS (pH 7.2): > 1 mg/ml
pka 4.66±0.10(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS02,GHS07
Signal word  Danger
NFPA 704
3
2 0

(5S,6Z,8E,10E,14Z)-5-hydroxy-12-oxoicosa-6,8,10,14-tetraenoic acid price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 20140 12-oxo Leukotriene B4 ≥90% 136696-10-1 25μg $222 2024-03-01 Buy
Cayman Chemical 20140 12-oxo Leukotriene B4 ≥90% 136696-10-1 50μg $414 2024-03-01 Buy
Cayman Chemical 20140 12-oxo Leukotriene B4 136696-10-1 10μg $106 2024-03-01 Buy
Cayman Chemical 20140 12-oxo Leukotriene B4 ≥90% 136696-10-1 100μg $723 2024-03-01 Buy
TRC L330410 12-OxoleukotrieneB4inacetonitrile 136696-10-1 50μL $380 2021-12-16 Buy
Product number Packaging Price Buy
20140 25μg $222 Buy
20140 50μg $414 Buy
20140 10μg $106 Buy
20140 100μg $723 Buy
L330410 50μL $380 Buy

(5S,6Z,8E,10E,14Z)-5-hydroxy-12-oxoicosa-6,8,10,14-tetraenoic acid Chemical Properties,Uses,Production

Description

Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-LO pathway. It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. 12-oxo LTB4 is an initial metabolite of LTB4 formed via the LTB4 12-hydroxydehydrogenase pathway. It is rapidly converted to 10,11-dihydro-12-oxo-LTB4, followed by reduction of the 12-oxo group to give 10,11-dihydro-LTB4. 12-oxo-LTB4 (EC50 = 33 nM) is about 70-fold less potent than LTB4 (EC50 = 0.46 nM) at stimulating Ca2+ mobilization in human neutrophils. It is also significantly less potent than LTB4 at stimulating neutrophil migration with EC50 values of 170 and 2.7 nM for 12-oxo-LTB4 and LTB4, respectively.

Uses

12-oxo Leukotriene B4 in acetonitrile is a potent eicosanoid lipid mediators.

Definition

ChEBI: A long-chain fatty acid consisting of leukotriene B4 having a 12-keto group in place of the 12-hydroxy group.

(5S,6Z,8E,10E,14Z)-5-hydroxy-12-oxoicosa-6,8,10,14-tetraenoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

(5S,6Z,8E,10E,14Z)-5-hydroxy-12-oxoicosa-6,8,10,14-tetraenoic acid Suppliers

Global( 7)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6870 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
Energy Chemical 021-58432009 400-005-6266 marketing@energy-chemical.com China 44941 58
Shanghai Yiyan Biotechnology Co. , Ltd. 021-69985186 13611928337 3427709316@qq.com China 7984 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 8740 58
Supplier Advantage
Shanghai Hongye Biotechnology Co. Ltd 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Energy Chemical 58
Shanghai Yiyan Biotechnology Co. , Ltd. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58

136696-10-1((5S,6Z,8E,10E,14Z)-5-hydroxy-12-oxoicosa-6,8,10,14-tetraenoic acid)Related Search:

(5S,6Z,8E,10E,14Z)-5-hydroxy-12-oxoicosa-6,8,10,14-tetraenoic acid 2,4-HEPTADIEN-6-ONE
(5S,6Z,8E,10E,14Z)-5-hydroxy-12-oxoicosa-6,8,10,14-tetraenoic acid 12-Keto-leukotriene B4 12-oxoleukotriene B4 12-Oxo-ltb4 6,8,10,14-Eicosatetraenoic acid, 5-hydroxy-12-oxo-, (S-(E,Z,E,Z))- 12-dehydro-leukotriene B4 SJVWVCVZWMJXOK-NOJHDUNKSA-N 6,8,10,14-Eicosatetraenoic acid, 5-hydroxy-12-oxo-, (5S,6Z,8E,10E,14Z)- 136696-10-1