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Medroxyprogesterone Acetate

Medroxyprogesterone Acetate
Medroxyprogesterone Acetate structure
Chemical Name:
Medroxyprogesterone Acetate
Molecular Formula:
Formula Weight:
MOL File:

Medroxyprogesterone Acetate Properties

Melting point:
206-207 °C(lit.)
D +61° (in chloroform)
Boiling point:
432.7°C (rough estimate)
1.0346 (rough estimate)
refractive index 
48 ° (C=1, Dioxane)
storage temp. 
Practically insoluble in water, freely soluble in methylene chloride, soluble in acetone, sparingly soluble in ethanol (96 per cent)
Water Solubility 
<0.1 g/100 mL at 23 ºC
Stable, but weakly air and light sensitive. Incompatible with strong oxidizing agents.
CAS DataBase Reference
71-58-9(CAS DataBase Reference)
EPA Substance Registry System
Pregn-4-ene-3,20- dione, 17-(acetyloxy)-6-methyl-, (6.alpha.)-(71-58-9)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn
Risk Statements  40-48
Safety Statements  22-36/37/39-45
WGK Germany  3
RTECS  TU5010000
HS Code  29372390
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H351 Suspected of causing cancer Carcinogenicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P281 Use personal protective equipment as required.

Medroxyprogesterone Acetate price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 46412 Medroxyprogesterone 17-acetate VETRANAL 71-58-9 250mg $53 2018-11-20 Buy
Sigma-Aldrich 1378001 Medroxyprogesterone acetate United States Pharmacopeia (USP) Reference Standard 71-58-9 200mg $352.8 2018-11-20 Buy
Cayman Chemical 23664 Medroxyprogesterone 17-acetate ≥98% 71-58-9 1g $93 2018-11-19 Buy
Cayman Chemical 23664 Medroxyprogesterone 17-acetate ≥98% 71-58-9 500mg $49 2018-11-19 Buy
Sigma-Aldrich Y0001484 Medroxyprogesterone acetate for peak identification European Pharmacopoeia (EP) Reference Standard 71-58-9 y0001484 $179 2018-11-23 Buy

Medroxyprogesterone Acetate Chemical Properties,Uses,Production

Chemical Properties

White or almost white, crystalline powder.


Progestogen; an injectable contraceptive.




A synthetic progesterone receptor agonist

brand name

Amen (Amarin); Curretab (Solvay Pharmaceuticals); Cycrin (ESI); Provera (Pharmacia & Upjohn);Clinovie;Cliovir;Dep0-clinover;Dep0-map;Depcorlutin;Depo-prodasone;Depo-progevera;Depo-promone;Deporone;Dugen;Farlurin;Farlutale;Gesinal;Gestapuran;Gestapuron;G-farlutal;Hysron;Intex;Luteocrin orale;Luteodione;Luteos;Lutoporal;Metigestene;Nadigest;Nogest;Onco-provera;Perlutest;Petogen;Piermap;Povera;Promone-e;Pronone;Proverone;Provest;Sindomens;Sodelut "g";Supprestal;Verafen;Veramix plus v.

World Health Organization (WHO)

A depot preparation containing 150 mg medroxyprogesterone acetate was introduced over 20 years ago for use as a long-acting injectable contraceptive. Subsequently, positive results of carcinogenicity studies carried out in beagle bitches led to refusal of registration in the United States. These findings were later considered irrelevant to contraceptive use in women and the drug was approved by the Food and Drug Administration. Menstrual irregularities are the most common adverse effect associated with depot medroxyprogesterone acetate. Risk-benefit judgements differ significantly from country to country, having regard to differing national circumstances. The preparation is, however, widely available and is included in the WHO Model List of Essential Drugs. (Reference: (WHTAC4) The Use of Essential Drugs, 4th Report of the WHO Expert Committee, 796, , 1990)

General Description

MPA, 17-acetyloxy-6α-methylpregn-4-ene-3,20-dione (Provera), adds a6α-methyl group to the basic 17α-hydroxyprogesteronestructure to greatly decrease the rate of reduction of the 4-ene-3-one system. The 17α-acetate group also decreases reductionof the 20-one, similar to the 17α-caproate. MPA isvery active orally and has such a long durationof action intramuscularly that it cannot be routinely usedintramuscularly for treating many menstrual disorders. TheIM formulation is useful in the palliative treatment of advancedendometrial, breast, and renal carcinomas. MPA alsohas an important role in several birth control products (Depo-Provera, Depo-SubQ Provera 104).

General Description

Odorless white to off-white microcrystalline powder.

Air & Water Reactions

Medroxyprogesterone 17-acetate is sensitive to prolonged exposure to air and light. Insoluble in water.

Reactivity Profile

Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert them to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides.


Possible carcinogen.

Fire Hazard

Flash point data for Medroxyprogesterone 17-acetate are not available; however, Medroxyprogesterone 17-acetate is probably combustible.

Safety Profile

Suspected carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Human systemic effects by intravenous route: increased intraocular pressure. Human teratogenic effects by an unspecified route: developmental abnormalities of the urogenital system. Human reproductive effects by multiple routes: spermatogenesis, menstrual cycle changes or dlsorders, postpartum effects, female fertility effects, abortion, newborn behavioral effects. Human mutation data reported. Experimental reproductive effects. A drug for the treatment of secondary amenorrhoea and dysfunctional uterine bleeding. When heated to decomposition it emits acrid smoke and irritating fumes.

Medroxyprogesterone Acetate Preparation Products And Raw materials

Raw materials

Preparation Products

Medroxyprogesterone Acetate Suppliers

Global( 309)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 China 19919 60
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 CHINA 3203 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 21922 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20680 55
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32457 55
020-81716319 CHINA 2543 55
Meihua Biological Technology Co.,Ltd
031145896235 CHINA 211 58
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114 CHINA 6374 58
Hebei Chisure Biotechnology Co., Ltd.
+8613091036086; +8613292890173
+8613292893290; CHINA 1019 58
career henan chemical co
+86-371-86658258 CHINA 20580 58

View Lastest Price from Medroxyprogesterone Acetate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-20 Medroxyprogesterone 17-acetate
US $1.00 / KG 1G 98% 100KG career henan chemical co
2018-07-20 Medroxyprogesterone 17-acetate
US $10.00 / KG 10G 99% 500kg/month Hebei Chisure Biotechnology Co., Ltd.
2018-09-30 medroxyprogesterone acetate
US $50.00 / KG 1KG 99% 20 MT Hebei Huanhao Biotechnology Co., Ltd.

Medroxyprogesterone Acetate Spectrum

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