4-Methoxy-1H-indazol-3-amine
- CAS No.
- 886362-07-8
- Chemical Name:
- 4-Methoxy-1H-indazol-3-amine
- Synonyms
- 4-Methoxy-1H-indazol-3-amine;4-methoxy-1H-indazol-4-amine;4-Methoxy-1H-indazol-3-ylamine;1H-Indazol-3-aMine, 4-Methoxy-;4-methoxy-1H-indoleazole-3-amine;4-(Methyloxy)-1H-indazol-3-amine;3-Amino-4-methoxy-1H-indazole 95%
- CBNumber:
- CB8135645
- Molecular Formula:
- C8H9N3O
- Molecular Weight:
- 163.18
- MDL Number:
- MFCD08276946
- MOL File:
- 886362-07-8.mol
- MSDS File:
- SDS
| Melting point | 85-87°C |
|---|---|
| Boiling point | 406.3±25.0 °C(Predicted) |
| Density | 1.344 |
| storage temp. | 2-8°C, protect from light |
| pka | 15.19±0.40(Predicted) |
| form | solid |
| Appearance | White to off-white Solid |
| InChI | InChI=1S/C8H9N3O/c1-12-6-4-2-3-5-7(6)8(9)11-10-5/h2-4H,1H3,(H3,9,10,11) |
| InChIKey | JZAMRGWQDJMEJD-UHFFFAOYSA-N |
| SMILES | N1C2=C(C(OC)=CC=C2)C(N)=N1 |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 22 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2933998090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| NFPA 704 |
|
4-Methoxy-1H-indazol-3-amine price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 755192 | 3-Amino-4-methoxy-1H-indazole 96% | 886362-07-8 | 1g | $66.5 | 2023-01-07 | Buy |
| Apolloscientific | OR15340 | 3-Amino-4-methoxy-1H-indazole 95% | 886362-07-8 | 1g | $30 | 2026-06-04 | Buy |
| Apolloscientific | OR15340 | 3-Amino-4-methoxy-1H-indazole 95% | 886362-07-8 | 5g | $109 | 2026-06-04 | Buy |
| Apolloscientific | OR15340 | 3-Amino-4-methoxy-1H-indazole 95% | 886362-07-8 | 25g | $360 | 2026-06-04 | Buy |
| Matrix Scientific | 046012 | 4-Methoxy-1H-indazol-3-amine | 886362-07-8 | 1.00g | $63 | 2026-05-18 | Buy |
4-Methoxy-1H-indazol-3-amine Chemical Properties,Uses,Production
Uses
4-Methoxy-1H-indazol-3-amine is used as a reactant in the preparation and structure-activity relationship of indazole arylsulfonamides as allosteric CC-chemokine receptor 4 antagonists.
Synthesis
A mixture of 2-fluoro-6-(methyloxy)benzonitrile (8a) (10 g, 66 mmol) and hydrazine hydrate (9.63 mL, 198 mmol) in n-butanol (100 mL) was heated to reflux under nitrogen for 18 h. The reaction mixture was allowed to cool, water (300 mL) was added and the organic phase was removed. The solid in the aqueous phase was collected by filtration and dried in vacuo at 40 C to give a white solid (0.6 g). The butanol phase was evaporated in vacuo and the residue and the aqueous mother liquors were combined and extracted using ethyl acetate (2 á 200 mL). The combined ethyl acetate extractions were dried (MgSO4) and evaporated in vacuo. The residue was dissolved in DCM and applied to a 100 g silica cartridge. This was eluted with cyclohexane (500 mL), cyclohexane ethyl acetate (1:1, 500 mL) and ethyl acetate (500 mL). The required fractions were combined and evaporated in vacuo to give 9a (9.92 g, 92%) as an off-white solid. MS ES + ve m/z 164 (M + H)+. 1H NMR | (DMSO-d6) 11.35 (1H, s), 7.10 (1H, t, J = 8 Hz), 6.76 (1H, d, J = 8 Hz), 6.29 (1H, d, J = 8 Hz), 4.95 (2H, br s), 3.85 (3H, s).
4-Methoxy-1H-indazol-3-amine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd. | 21-57721279 18121011378 | sales@shydchem.com.cn | China | 998 | 56 |
| Shanghai ChuangYan Chemical Technology Co., Ltd. | 021-11111111 11111111111 | 546919421@qq.com | China | 3770 | 55 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 14982 | 55 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Struchem Co., Ltd. | 0512-63009836 18994340901 | helen@struchem.com | China | 3970 | 60 |
| Shanghai Brain Biotechnology Co., Ltd. | 13564638271 | shhjiang1977@163.com | China | 2985 | 55 |
View Lastest Price from 4-Methoxy-1H-indazol-3-amine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-01 | 4-METHOXY-1H-INDAZOL-3-AMINE
886362-07-8
|
$1.00 | 1KG | 95-99% | 1ton | Career Henan Chemical Co |
-
- 4-METHOXY-1H-INDAZOL-3-AMINE
886362-07-8
- $1.00
- 95-99%
- Career Henan Chemical Co
