asterric acid
- CAS No.
- 577-64-0
- Chemical Name:
- asterric acid
- Synonyms
- asterric acid;DiMethylosoic acid,TAN 1415A, WF 12880A;2-(2-Methoxycarbonyl-4-hydroxy-6-methoxyphenoxy)-4-methyl-6-hydroxybenzoic acid;Benzoic acid, 2-(2-carboxy-3-hydroxy-5-methylphenoxy)-5-hydroxy-3-methoxy-, 1-methyl ester
- CBNumber:
- CB81365102
- Molecular Formula:
- C17H16O8
- Molecular Weight:
- 348.3
- MDL Number:
- MFCD00216131
- MOL File:
- 577-64-0.mol
- MSDS File:
- SDS
Melting point | 208-214 °C |
---|---|
Boiling point | 557.6±50.0 °C(Predicted) |
Density | 1.406±0.06 g/cm3(Predicted) |
storage temp. | -20°C |
solubility | Soluble in ethanol;Soluble in DMSO;Soluble in dimethyl formamide |
form | solid |
pka | 2.97±0.34(Predicted) |
color | white |
FDA UNII | J3Q23XL4KN |
asterric acid price More Price(8)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | SMB00012 | Asterric acid ≥95% (LC/MS-ELSD) | 577-64-0 | 1mg | $407 | 2024-03-01 | Buy |
Cayman Chemical | 70630 | Asterric Acid ≥99% | 577-64-0 | 1mg | $214 | 2024-03-01 | Buy |
Cayman Chemical | 70630 | Asterric Acid ≥99% | 577-64-0 | 5mg | $796 | 2024-03-01 | Buy |
TRC | A790158 | Asterric acid | 577-64-0 | 1mg | $160 | 2021-12-16 | Buy |
Usbiological | A3884 | Asterric Acid | 577-64-0 | 1mg | $460 | 2021-12-16 | Buy |
asterric acid Chemical Properties,Uses,Production
Uses
Asterric acid is a fungal metabolite with anti-angiogenic properties, isolated from a number of Aspergillus and Penicillium species. It is an inhibitor of vascular endothelial growth factor (VEGF), inhibiting VEGF-induced tube formation of human umbilical vein endothelial cells.
Biological Activity
asterric acid is an eta receptor inhibitor.endothelin (et), a potent vasoconstrictor/pressor peptide consisting of 21 amino acid residues, was first isolated from the cultures of porcine aortic endothelial cells. analyses of a human genomic library reveals three forms of et (et-1, et-2 and et-3) with more than 70% homology with one another. in various organs, high affinity and specific receptors for et have been found, which have been classfied as receptors eta and etb. et-1 has potent and long-lasting vasoconstrictive activity, as a result of binding to the eta receptor.
in vitro
previous study asterric acid isolated as an active substance from the culture filtrate of a fungus, aspergillus sp. asterric acid had also been reported as a metabolite of a fungus. it was found that asterric acid had the property of inhibiting et-1 binding to the eta receptor of a10 cells, but it showed no inhibitory activity against anp and a ii binding at 10 mm, which indicated that asterric acid displayed as a specific inhibitor of et-1 binding [1].
IC 50
10 μm for et-1 binding to the eta receptor ofa10 cells
References
[1] ohashi, h. ,akiyama, h.,nishikori, k., et al. asterric acid, a new endothelin binding inhibitor. journal of antibiotics 45, 1684-1685 (1992).
asterric acid Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
BOC Sciences | +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49999 | 58 |
Lynnchem | 86-(0)29-85992781 17792393971 | info@lynnchem.com | China | 4587 | 58 |
Novachemistry | 44-20819178-90 02081917890 | info@novachemistry.com | United Kingdom | 4381 | 58 |
Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55717 | 58 |
Meng Cheng Technology (Shanghai) Co., LTD | 400-820-6829 | sales@mitachieve.com | China | 8864 | 58 |
Zhejiang Huida Biotech Co., LTD | 0571-89903882 13626641628 | jiangnan@huidabiotech.com | China | 3661 | 58 |
Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
Zhejiang Huida Biotech Co., LTD | 0571-0571-89903882 15990081639 | sunshixuan@huidabiotech.com | China | 3705 | 58 |
Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8740 | 58 |
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