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Lincomycin hydrochloride

Antibiotic medicines Clinical application
Lincomycin hydrochloride
Lincomycin hydrochloride structure
Chemical Name:
Lincomycin hydrochloride
Lizpion;U-10149A;Lincogap;Lincocin;Lincorex;Lintamycin;Pelancocin;Luniamycin;Lyncomycin,HCl;Lincoymcin Hcl
Molecular Formula:
Formula Weight:
MOL File:

Lincomycin hydrochloride Properties

Melting point:
storage temp. 
H2O: 50 mg/mL, clear, colorless
white to white with yellow cast
Water Solubility 
Soluble in water.
  • Risk and Safety Statements
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338-P280a-P304+P340-P405-P501a
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-20/21/22
Safety Statements  26-36
WGK Germany  2
RTECS  RH6315000
HS Code  29419000

Lincomycin hydrochloride price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 62143 Lincomycin hydrochloride ≥95.0% (TLC) 859-18-7 1g $69 2018-11-13 Buy
Sigma-Aldrich 62143 Lincomycin hydrochloride ≥95.0% (TLC) 859-18-7 5g $276 2018-11-13 Buy
Alfa Aesar J61251 Lincomycin hydrochloride 859-18-7 5g $152 2018-11-13 Buy
Alfa Aesar J61251 Lincomycin hydrochloride 859-18-7 1g $42.1 2018-11-13 Buy
Sigma-Aldrich L2774 Lincomycin hydrochloride BioReagent, suitable for cell culture 859-18-7 1mu $56.6 2018-11-20 Buy

Lincomycin hydrochloride Chemical Properties,Uses,Production

Antibiotic medicines

Lincomycin hydrochloride appears as a white crystalline powder at room temperature with slight odor or special smell and bitter taste. It is soluble in water and methanol. Feed often applied its hydrochloride salt form. The drug is the product during the growth of the population of the Streptomyces genus (Streptomyces lincolnensis), as a kind of lincosamides alkaline antibiotics. Through interaction with the 50S ribosomal subunit of the sensitive bacteria, it prevents the peptide chain elongation, thereby inhibiting protein synthesis of the bacterial cell with antimicrobial effect. However, at high concentrations, it also has bactericidal effect on the highly sensitive bacteria. Its antibacterial spectrum is the same as lincomycin but with a stronger antibacterial activity and can be subject to oral absorption quickly and completely (about 90%) with meal having little effect on the absorption. Lincomycin hydrochloride mainly has strong antibacterial effect against Gram-positive bacteria, and some anaerobic bacteria as well as Mycoplasma with its antibacterial spectrum narrower than erythromycin. Staphylococcus aureus, Streptococcus pneumoniae and Mycoplasma pneumonia Mycoplasma hyopneumoniae, and Mycoplasma gallisepticum are sensitive to the chemicals, but enterococci is generally resistant to the chemicals; anaerobic bacteria such as Bacteroides spp., Clostridium tetani, Clostridium difficile, Clostridium perfringens and Peptococcus are also sensitive to the chemicals. It is mainly used for the treatment of infections caused by Gram-positive bacteria in particular the various penicillin-resistant Gram-positive bacteria , the poultry chronic respiratory disease caused by Mycoplasma, swine enzootic pneumonia, anaerobic infections such as chicken necrotizing enterocolitis. It can also be used for the treatment of treponema dysentery, toxoplasmosis and actinomycosis of dogs and cats.
Lincomycin hydrochloride has therapeutic effect when being used for the treatment of Sepsis, female genital tract, endometritis, non-gonococcal tubo-ovarian abscess, pelvic cellulitis; postoperative vaginal annex infections, peritonitis, abscesses, pneumonia, lung abscess, skin and soft tissue infections caused by most Gram-negative bacteria and some anaerobic bacteria. It can also be used for the surgical adjuvant treatment of Sepsis caused by streptococci and staphylococci, bone and joint infections, chronic bone and joint infections as well as the acute hematogenous osteomyelitis of Staphylococcus aureus. But this product can’t penetrate into cerebrospinal fluid and therefore not suitable for the treatment of meningitis. Topical administration can be applied for the treatment of Gram-positive bacteria purulent infection.

Clinical application

1. Oral formulations is suitable for treating respiratory infections, abdominal infection, female reproductive tract infections, pelvic infections, skin and soft tissue infections caused by sensitive Staphylococcus aureus and Streptococcus pneumoniae.
2. In addition to the treatment of the above infections, injected formulations are suitable for treatment of severe infections caused by streptococcus, pneumococcus and staphylococcus such as the surgical adjuvant therapy of septicemia, bone and joint infections, chronic bone and joint infections and Staphylococcus-induced acute hematogenous osteomyelitis.
3. Lincomycin hydrochloride may also be used for the treatment of infectious diseases in patients allergic to penicillin or not suitable for administration of penicillin-type drugs.
Tablets: Each tablet 0.25g, 0.5g; Injection: each 0.2g, 0.6g.
This information is edited by Xiongfeng Dai from Chemicalbook.

Chemical Properties



An antibiotic produced by Streptomyces lincolnensis. Lincomycin is a lincosamide antibiotic that forms cross-links within the peptidyl transferase loop region of the 23S rRNA. Inhibits bacterial protein synthesis. Antibacterial.


Antibacterial;Ribosomal protein synthesis inhibitor


Lincomycin hydrochloride is a salt of lincomycin formed at the basic N-methylproline. The hydrochloride salt is the preferred formulation for pharmaceutical use. Lincomycin hydrochloride is a broad spectrum antibiotic with activity against anaerobic bacteria and protozoans. Lincomycin acts by binding to the 23S ribosomal subunit, blocking protein synthesis. Lincomycin has been extensively studied with over 7,000 literature citations.

brand name

Lincocin (Pharmacia & Upjohn).

Clinical Use

Lincomycin is used for the treatment of infections causedby Gram-positive organisms, notably staphylococci, β-hemolyticstreptococci, and pneumococci. It is absorbed moderatelywell orally and distributed widely in the tissues.Effective concentrations are achieved in bone for the treatmentof staphylococcal osteomyelitis but not in the cerebrospinalfluid for the treatment of meningitis. At one time,lincomycin was considered a nontoxic compound, with alow incidence of allergy (rash) and occasional GI complaints(nausea, vomiting, and diarrhea) as the only adverseeffects. Recent reports of severe diarrhea and the developmentof pseudomembranous colitis in patients treated withlincomycin (or clindamycin), however, have necessitatedreappraisal of the role of these antibiotics in therapy. In anyevent, clindamycin is superior to lincomycin for thetreatment of most infections for which these antibiotics areindicated.
Lincomycin hydrochloride occurs as the monohydrate, awhite, crystalline solid that is stable in the dry state. It isreadily soluble in water and alcohol, and its aqueous solutionsare stable at room temperature. It is degraded slowlyin acid solutions but is absorbed well from the GI tract.Lincomycin diffuses well into peritoneal and pleural fluidsand into bone. It is excreted in the urine and the bile. It isavailable in capsule form for oral administration and inampules and vials for parenteral administration.

Lincomycin hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Lincomycin hydrochloride Suppliers

Global( 255)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Anhui Royal Chemical Co., Ltd.
+86-025-86736275 CHINA 488 55
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 CHINA 3194 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 21701 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32447 55
020-81716319 CHINA 2543 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
02783214688 CHINA 535 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 China 1852 55
career henan chemical co
+86-371-86658258 CHINA 29979 58
Chemwill Asia Co.,Ltd.
86-21-51861608;;; CHINA 23978 58

View Lastest Price from Lincomycin hydrochloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-07-23 Lincomycin hcl
US $1.00 / g 1g 99% 20 Ton/Tons per Month Cangzhou Wanyou New Material Technology Co.,Ltd
2018-08-17 Lincomycin hydrochloride
US $1.00 / KG 1G 98% 100KG career henan chemical co
2018-09-26 Lincomycin Hydrochloride CAS 859-18-7
US $10.00 / G 10G 99% 10mt Hubei XinRunde Chemical Co., Ltd.

Lincomycin hydrochloride Spectrum

859-18-7(Lincomycin hydrochloride)Related Search:

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