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4-Fluoroaniline

4-Fluoroaniline structure

CAS No.: 371-40-4

Chemical Name:: 4-Fluoroaniline

Synonyms: P-FLUOROANILINE;fluoroanilines;4-fluorobenzenamine;1-AMINO-4-FLUOROBENZENE;NSC 579;uoroaniL;AKOS 91149;4-Fluoranilin;4-fluoro-anilin;p-fluoro-anilin

CBNumber:: CB8143013

Molecular Formula:: C6H6FN

Molecular Weight:: 111.12

MDL Number:: MFCD00007829

MOL File:: 371-40-4.mol

Last updated:2023-09-01 17:37:15

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4-Fluoroaniline Properties

Melting point	-1.9 °C
Boiling point	187 °C/767 mmHg (lit.)
Density	1.173 g/mL at 25 °C (lit.)
refractive index	n20/D 1.539(lit.)
Flash point	165 °F
storage temp.	2-8°C
solubility	33g/l
pka	4.65(at 25℃)
form	Oily Liquid
color	Clear pale yellow to red-brown
Specific Gravity	1.173
Water Solubility	33 g/L (20 ºC)
Merck	14,4169
BRN	742030
Stability	Stable. Incompatible with acids, oxidizing agents.
CAS DataBase Reference	371-40-4(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	60HI1G076Z
NIST Chemistry Reference	p-Fluoroaniline(371-40-4)
EPA Substance Registry System	p-Fluoroaniline (371-40-4)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS07,GHS08,GHS09

Signal word

Danger

Hazard statements

H302-H314-H373-H410

Precautionary statements

P273-P280-P301+P312-P303+P361+P353-P305+P351+P338-P314

Hazard Codes

C,T,Xi,Xn

Risk Statements

22-34-36/38-33-23/24/25

Safety Statements

26-36/37/39-45-37/39-28

RIDADR

UN 2941 6.1/PG 3

WGK Germany

RTECS

BY1575000

Hazard Note

Toxic/Irritant

TSCA

HazardClass

6.1

PackingGroup

III

HS Code

29214210

NFPA 704

	2
3		0

4-Fluoroaniline price More Price(32)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	F3800	4-Fluoroaniline 99%	371-40-4	25g	$24.1	2024-03-01	Buy
TCI Chemical	F0033	4-Fluoroaniline >98.0%(GC)(T)	371-40-4	25mL	$50	2024-03-01	Buy
TCI Chemical	F0033	4-Fluoroaniline >98.0%(GC)(T)	371-40-4	500mL	$528	2021-12-16	Buy
Alfa Aesar	A15597	4-Fluoroaniline, 99%	371-40-4	25g	$24	2024-03-01	Buy
Alfa Aesar	A15597	4-Fluoroaniline, 99%	371-40-4	100g	$43.1	2024-03-01	Buy

Product number	Packaging	Price	Buy
F3800	25g	$24.1	Buy
F0033	25mL	$50	Buy
F0033	500mL	$528	Buy
A15597	25g	$24	Buy
A15597	100g	$43.1	Buy

4-Fluoroaniline Chemical Properties,Uses,Production

Chemical Properties

4-Fluoroaniline is a light yellow to gold-coloured liquid.It is easy to oxidize and turn red in air.

Uses

4-Fluoroaniline is a degradation product of Ezetimibe (E975000). 4-Fluoroaniline is used as an analytical reagent in the enzymic detection of glucose.

Uses

4-Fluoroaniline may be employed as one of the target pollutant during the investigation of biodegradability of fluorinated compounds under aerobic conditions. It may be used for the synthesis of luminescent and cationic monocyclometalated gold(III) monoaryl complexes.

Uses

Intermediate in the manufacture of herbicides and plant growth regulators.

Preparation

The better process in the one-step process is the nitrobenzene method, which is obtained by deoxygenation, hydrogenation and fluorination. With PdCl2-V2O5 as the catalyst and carbon monoxide as the reducing agent, the reaction was carried out at 160°C for 3h, and the yield of 4-fluoroaniline could reach 90%, with another 10% of aniline as a by-product. With PtO2 as the catalyst, BF3-HF as the fluorinating agent and hydrogen as the reducing agent, the reaction was carried out at 42℃ for 12.5h, with 100% conversion and 95% yield.

Definition

ChEBI: 4-fluoroaniline is a primary arylamine that is the derivative of aniline in which the hydrogen at position 4 has been substituted by fluorine. It is used as an intermediate in the manufacture of pharmaceuticals, herbicides and plant growth regulators. It is a primary arylamine and a fluoroaniline.

Synthesis Reference(s)

Journal of the American Chemical Society, 70, p. 654, 1948 DOI: 10.1021/ja01182a065
The Journal of Organic Chemistry, 26, p. 4014, 1961 DOI: 10.1021/jo01068a089

General Description

4-fluoroaniline is a light-colored oily liquid. Mixture of three isomers. Insoluble in water and denser than water. Contact may cause irritation to skin, eyes, and mucous membranes. May be toxic by ingestion. Used to make other chemicals. The barriers to inversion and internal rotation of the NH2 group in 4-fluoroaniline has been investigated by far infrared gas spectra.

Hazard

Toxic material.

Flammability and Explosibility

Not classified

Safety Profile

Poison by ingestion. Mutation data reported. A severe skin and eye irritant. When heated to decomposition it emits very toxic fumes of NOx and F-.

4-Fluoroaniline synthesis

Synthesis of 4-Fluoroaniline from 4-Fluoronitrobenzene

4-Fluoroaniline Preparation Products And Raw materials

Raw materials

Phenyl phosphine Fluorine 4-Fluoronitrobenzene 4-Chloronitrobenzene Formic acid

Styrene Sulfolane Potassium fluoride N-Phenylhydroxylamine Polyethylene Glycol

Benzotrichloride Dimethyl sulfoxide N,N-Dimethylacetamide 15-Crown-5

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Preparation Products

6-Fluoro-4-(trifluoromethyl)quinolin-2-amine ,97% 2-Hydroxy-4-(trifluoromethyl)quinoline 1-FLUORO-4-(TRIFLUOROMETHYLTHIO)BENZENE 2-BROMO-6-METHYL-4-NITROANILINE N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline

4-BROMO-6-FLUORO-2-(TRIFLUOROMETHYL)QUINOLINE 4-(Trifluoromethyl)quinoline-2-carbohydrazide ,97% (6-Fluoro-4-(trifluoromethyl)quinolin-2-yl)methanol ,97% Ethyl 6-fluoro-4-(trifluoromethyl)quinoline-2-carboxylate ,97% 4-FLUORO-N-METHYLANILINE

2-Bromo-6-fluoro-4-(trifluoromethyl)quinoline 6-FLUORO-4-HYDROXY-2-(TRIFLUOROMETHYL)QUINOLINE (4-(Trifluoromethyl)quinolin-2-yl)methanol ,97% Sarafloxacin 4-(Trifluoromethyl)quinolin-2-amine

6-Fluoro-4-(trifluoromethyl)quinoline-2-carboxylic acid ,97% 2-BROMO-4-(TRIFLUOROMETHYL)QUINOLINE 4-Fluorophenyl isocyanate 6-Fluoro-4-(trifluoromethyl)-2(1H)-quinolinone 4-TRIFLUOROMETHYL-QUINOLINE-2-CARBOXYLIC ACID

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4-Fluoroaniline Suppliers

Global( 464)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Siyang Liaoning Biochemical Products Co. Ltd	+86-15221114306; +8615221114306	2594582574@qq.com	China	574	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12456	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Hi-Tech Chemistry Corp	0519-86626038	yuhh@hitechem.com	CHINA	811	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Fluoropharm Co., Ltd.	+86-0571-85586753; +8613336034509	sales@fluoropharm.com	China	1290	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
NINGBO INNO PHARMCHEM CO., LTD.	13867897135	sales@nbinno.com	CHINA	925	58
Zhejiang ZETian Fine Chemicals Co. LTD	18957127338	stella@zetchem.com	China	2141	58

Supplier	Advantage
Siyang Liaoning Biochemical Products Co. Ltd	58
Hebei Mojin Biotechnology Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Hi-Tech Chemistry Corp	58
Henan Tianfu Chemical Co.,Ltd.	55
Fluoropharm Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
NINGBO INNO PHARMCHEM CO., LTD.	58
Zhejiang ZETian Fine Chemicals Co. LTD	58

View Lastest Price from 4-Fluoroaniline manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-24	4-Fluoroaniline 371-40-4	US $0.00 / KG	1KG	≥99%	200mt	Jinan Finer Chemical Co., Ltd
2024-01-08	4-Fluoroaniline 371-40-4	US $10.00 / mL	1mL	99%	5000L	Wuhan Boyuan Import & Export Co., LTD
2023-09-01	4-Fluoroaniline 371-40-4	US $0.00 / KG	1KG	99%	50000KG/month	Hebei Mojin Biotechnology Co., Ltd

4-Fluoroaniline
371-40-4
US $0.00 / KG
≥99%
Jinan Finer Chemical Co., Ltd

4-Fluoroaniline
371-40-4
US $10.00 / mL
99%
Wuhan Boyuan Import & Export Co., LTD

4-Fluoroaniline
371-40-4
US $0.00 / KG
99%
Hebei Mojin Biotechnology Co., Ltd

4-Fluoroaniline Spectrum

4-Fluoroaniline(371-40-4)MS 4-Fluoroaniline(371-40-4)¹HNMR 4-Fluoroaniline(371-40-4)¹³CNMR 4-Fluoroaniline(371-40-4)IR1 4-Fluoroaniline(371-40-4)Raman

371-40-4(4-Fluoroaniline)Related Search:

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5-(4-FLUOROPHENYL)VALERIC ACID ent-EzetiMibe EzetiMibe (3R,4R,3'S)-IsoMer

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