- CAS No.
- Chemical Name:
- aminophyllin;ethophylline;THEOPHYLLINE ETHYLENEDIAMINE;theomin;euufilin;grifomin;miofilin;theodrox;theolone;cardiomin
- Molecular Formula:
- Molecular Weight:
- MDL Number:
- MOL File:
|Melting point||269-270 °C|
|storage temp.||Inert atmosphere,Store in freezer, under -20°C|
|solubility||H2O: 3.7 mg/mL solutions should be freshly prepared.|
|pka||pKa 5.0 (Uncertain)|
|color||white to off-white|
|CAS DataBase Reference||317-34-0(CAS DataBase Reference)|
|FDA 21 CFR||310.545|
|EWG's Food Scores||1-3|
|NCI Drug Dictionary||aminophylline|
|EPA Substance Registry System||1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, compd. with 1,2-ethanediamine (2:1) (317-34-0)|
Risk and Safety Statements
|RIDADR||UN 2811 6.1/PG 3|
|Toxicity||LD50 orally in mice: 540 mg/kg (Thompson, Warren)|
Aminophylline price More Price(25)
|Manufacturer||Product number||Product description||CAS number||Packaging||Price||Updated||Buy|
|Sigma-Aldrich||A1755||Aminophylline ≥98%, powder||317-34-0||25g||$59.6||2022-05-15||Buy|
|Sigma-Aldrich||A1755||Aminophylline ≥98%, powder||317-34-0||100g||$105||2022-05-15||Buy|
|Alfa Aesar||J60705||Aminophylline, anhydrous, 98%||317-34-0||25g||$31||2021-12-16||Buy|
|Alfa Aesar||J60705||Aminophylline, anhydrous, 98%||317-34-0||100g||$84.1||2021-12-16||Buy|
|Cayman Chemical||22235||Aminophylline ≥98%||317-34-0||25g||$22||2022-04-27||Buy|
Aminophylline Chemical Properties,Uses,Production
Aminophylline is a drug combination consisting of bronchodilator theophylline and ethylenediamine in 2: 1 ratio. It is a kind of non-selective adenosine receptor blocker, histone deacetylase activator and phosphodiesterase inhibition. It is mainly indicated for the treatment of various kinds of lung diseases including asthma, COPD, chronic bronchitis and emphysema. Aminophylline exerts its effect through the component of theophylline in vivo. Theophylline can relax the smooth muscle of the bronchial airways and pulmonary blood vessels. It can competitively inhibits type III and type IV phosphodiesterase (PDE), which breaks down cyclic AMP in smooth muscle cells, possibly leading to bronchodilation. Theophylline also binds to the adenosine A2B receptor to block the adenosine mediated bronchoconstriction. Furthermore, during the inflammatory states, theophylline can activate the histone deacetylase to prevent transcription of inflammatory genes that require the acetylation of histones to initiate the transcription.
Aminophylline is a 2/1 mixture of theophylline and ethylenediamine. It caused contact dermatitis in industrial plants, in pharmacists, and in nurses. Ethylenediamine is the sensitizer, and patch testing is generally positive to both ethylenediamine and aminophylline, but negative to theophylline.
white to slightly yellowish powder
Bronchodilatator;Mastocytes degranulation inhibitor
Aminophylline exhibits vasodilatory and anti-inflammatory activity and is occasionally clinically used to treat chronic obstructive pulmonary disorder (COPD). In animal models of allergen-induced lung inflammation, aminophylline decreases levels of IL-5, IL-8, and eosinophils. It is mostly used to prepare solutions for intravenous injections.
Aminophylline is a bronchodilator and a non-selective phosphodiesterase (PDE) inhibitor.
A mixture of 198 g (1 mol) theophylline and 60-78 g (0.75-1 mol) ethylenediamine hydrate in 300 g of water was stirred at 50°C and then the mixture was concentrated in vacuo. The product (aminophylline) was separeted by suction filtration. Aminophylline was used as an aqueous solution.
Phyllocontin (Purdue Frederick); Somophyllin (Fisons); Truphylline (G & W);Afonilum;Aminomal;Aminophylline injection;Aminophylline mudrane;Aminophylline oral;Amino-slow;Amnivent;Asmafilin;Cardophylline;Carine;Colonofilin;Corfilamine;Corophylline;Corphyllamin;Duraphyllin;Escophylline;Eudiamine;Euphyllin 0.48;Euphyllin retard;Euphylllin cr;Euphylllina;Fadfilina;Godafilin;Jaa aminophylline;Mini-lix;Mudrane gg;Mundiphyllin;Palaran;Palaron;Pecram;Pecran;Peterphylin;Phyllotemp;Planphylline;Somophyllin-12;Syntophyllin;Teophyllamin;Thodrox;Variaphylline.
Diuretic, Cardiac stimulant, Smooth muscle relaxant, Vasodilator
World Health Organization (WHO)
Aminophylline, the ethylenediamine salt of theophylline, was introduced many years ago as a treatment for asthma and is listed in the 8th WHO Model List of Essential Drugs. It has been recognized for some 10 years that aminophylline preparations are not interchangeable because bioavailability can vary considerably. The resulting variability in drug absorption can lead to adverse effects including irritation of the mucosa. Allergic reation can also be an adverse effect of aminophylline. Theophylline functions similarly but is considered less of an irritant.
Cardiovascular and respiratory collapse.
This drug is a 2:1 mixture of the alkaloid theophylline and ethylenediamine (see below). It caused contact dermatitis in industrial plants, pharmacists, and nurses. Ethylenediamine is the sensitizer and patch testing is generally positive to both ethylenediamine and aminophylline and negative to theophylline.
Reversible airways obstruction
Acute severe asthma
Veterinary Drugs and Treatments
The theophyllines are used primarily for their bronchodilatory effects, often in patients with myocardial failure and/or pulmonary edema. While they are still routinely used, the methylxanthines must be used cautiously due to their adverse effects and toxicity.
Potentially hazardous interactions with other drugs
Antibacterials: increased concentration with azithromycin, clarithromycin, erythromycin, ciprofloxacin, norfloxacin and isoniazid; decreased erythromycin levels if erythromycin is given orally; increased risk of convulsions if given with quinolones; rifampicin accelerates metabolism of aminophylline.
Antidepressants: concentration increased by fluvoxamine - avoid or halve theophylline dose and monitor levels; concentration reduced by St John’s wort - avoid.
Antiepileptics: metabolism increased by carbamazepine, phenobarbital and primidone; concentration of both drugs increased with fosphenytoin and phenytoin.
Antifungals: concentration increased by fluconazole and ketoconazole.
Antivirals: metabolism of aminophylline increased by ritonavir; concentration possibly increased by aciclovir.
Calcium-channel blockers: concentration increased by diltiazem and verapamil and possibly other calcium-channel blockers.
Deferasirox: concentration of aminophylline increased.
Feboxostat: use with caution.
Interferons: reduced metabolism of aminophylline.
Tacrolimus: may increase tacrolimus levels.
Ulcer-healing drugs: metabolism inhibited by cimetidine; absorption possibly reduced by sucralfate.
Aminophylline is metabolised to theophylline in vivo. Theophylline is excreted in the urine as metabolites, mainly 1,3-dimethyluric acid and 3-methylxanthine, and about 10% is excreted unchanged.
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View Lastest Price from Aminophylline manufacturers
|Image||Update time||Product||Price||Min. Order||Purity||Supply Ability||Manufacturer|
|US $14.00 / Kg/Bag||1Kg/Bag||99.8%||Weekly supply of 1000 KG||Wuhan Dujiang Industrial Co., Ltd.|
|US $1.00 / kg||1kg||99%||1 tons||Jiangsu Bangdeya New Material Technology Co.,Ltd|
|US $30.00 / kg||100kg||98%||10000kg||Hebei Yime New Material Technology Co., Ltd.|