L-A-HYDROXYGLUTARIC ACID DISODIUM)
- CAS No.
- 63512-50-5
- Chemical Name:
- L-A-HYDROXYGLUTARIC ACID DISODIUM)
- Synonyms
- L-2-HG;SKL187;Disodium (S)-2-hydroxyglutarate;(S)-2-Hydroxypentanedioic acid;Sodium (S)-2-hydroxypentanedioate;L-2-Hydroxyglutarate DisodiuM Salt;L-α-Hydroxyglutaricaciddisodiumsal;L-2-Hydroxyglutaric acid (disodium);(S)-2-Hydroxyglutaric acid disodium;L-ALPHA-HYDROXYGLUTARIC ACID DISODIU
- CBNumber:
- CB81473690
- Molecular Formula:
- C5H9NaO5
- Molecular Weight:
- 172.11
- MDL Number:
- MFCD00021700
- MOL File:
- 63512-50-5.mol
- MSDS File:
- SDS
L-A-HYDROXYGLUTARIC ACID DISODIUM) price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 90790 | L-α-Hydroxyglutaric acid disodium salt ≥98.0% (GC) | 63512-50-5 | 10mg | $94.1 | 2024-03-01 | Buy |
| Sigma-Aldrich | 90790 | L-α-Hydroxyglutaric acid disodium salt ≥98.0% (GC) | 63512-50-5 | 50mg | $328 | 2024-03-01 | Buy |
| Cayman Chemical | 11876 | L-α-Hydroxyglutaric Acid (sodium salt) ≥95% | 63512-50-5 | 5mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 11876 | L-α-Hydroxyglutaric Acid (sodium salt) ≥95% | 63512-50-5 | 10mg | $61 | 2024-03-01 | Buy |
| Cayman Chemical | 11876 | L-α-Hydroxyglutaric Acid (sodium salt) ≥95% | 63512-50-5 | 25mg | $131 | 2024-03-01 | Buy |
L-A-HYDROXYGLUTARIC ACID DISODIUM) Chemical Properties,Uses,Production
Description
L-α-Hydroxyglutaric acid (L-2-HG) is an α-hydroxy acid. It is metabolized to 2-oxoglutarate (α-ketoglutarate) by L-2-hydroxyglutarate dehydrogenase, and mutations in this enzyme lead to 2-hydroxyglutaric aciduria, a neurometabolic disorder characterized by increased L-2-HG levels. L-2-HG is structurally similar to α-ketoglutarate and competitively inhibits α-ketoglutarate-dependent dioxygenases, including several involved in histone lysine and DNA demethylation.
Chemical Properties
White Solid
Uses
L-α-Hydroxyglutaric acid disodium salt is suitable for use in collection buffer for increased recovery of hypoxia-inducible factor-1 α (HIF-1α), a marker of hypoxia in human tumors. It is also suitable for the radiolabeled 5mC-5hmC conversion assay to study the effect of 2-HG on the TET family of methyl hydroxylases.
Uses
A potential inhibitor of glutamate carboxypeptidase.
General Description
Glutamic acid is metabolized to α-Hydroxyglutaric acid in an NAD-dependent manner by cell-free extracts of Peptococcus aerogenes. It is formed as an intermediate during glyoxylic acid metabolism in bacteria.
Biochem/physiol Actions
L-alpha-Hydroxyglutaric acid accumulates as a result of a rare defect in L-2-HG dehydogenase, leading to the metabolic disorder L-2-hydroxyglutaric aciduria (L-2HGA). L-2HGA is associated with neuronal defects, leukodystrophy and linked to an increased risk of brain tumors.
in vitro
it has been reported that l-α-hydroxyglutaric acid disodium salt could be used as the collection buffer for increasing the recovery of hypoxia-inducible factor-1 α, which was a marker of hypoxia in human tumors [1]. in another previous study, l-α-hydroxyglutaric acid disodium salt was also used in the radiolabeled conversion assay to evaluate its effect on the tet family of methyl hydroxylases [2].
in vivo
in the 30-day-old rats, l-α-hydroxyglutaric acid was found to be able to significantly increase chemiluminescence, pcf and tba-rs measurements and decrease the tar values in cerebellum markedly. in addition, the l-α-hydroxyglutaric acid-induced increase of tba-rs was significantly attenuated by melatonin and also by the combinations of ascorbic acid and soluble alpha-tocopherol (trolox) and of superoxide dismutase plus catalase but not by the inhibitor of nitric oxide synthase nomega-nitro-l-arginine methyl ester (l-name), , superoxide dismutase or creatine or catalase alone in either cerebral structure [3].
References
[1] park sr,kinders rj,khin s,et al. validation of a hypoxia-inducible factor-1 alpha specimen collection procedure and quantitative enzyme-linked immunosorbent assay in solid tumor tissues. anal biochem.2014 aug 15;459:1-11.
[2] evans b,griner e. registered report: oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. elife.2015 jul 31;4:e07420.
[3] latini a,scussiato k,rosa rb,leipnitz g,llesuy s,belló-klein a,dutra-filho cs,wajner m. induction of oxidative stress by l-2-hydroxyglutaric acid in rat brain. j neurosci res.2003 oct 1;74(1):103-10.
L-A-HYDROXYGLUTARIC ACID DISODIUM) Preparation Products And Raw materials
Raw materials
Preparation Products
L-A-HYDROXYGLUTARIC ACID DISODIUM) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
| Henan Alfa Chemical Co., Ltd | +8618339805032 | alfa4@alfachem.cn | China | 12755 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49999 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33349 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
View Lastest Price from L-A-HYDROXYGLUTARIC ACID DISODIUM) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2020-01-14 | L-A-HYDROXYGLUTARIC ACID DISODIUM)
63512-50-5
|
US $1.00 / g | 1g | 99% | 200kg | Career Henan Chemical Co |
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- L-A-HYDROXYGLUTARIC ACID DISODIUM)
63512-50-5
- US $1.00 / g
- 99%
- Career Henan Chemical Co