ZOSUQUIDAR TRIHYSROCHLORIDE
- CAS No.
- 167465-36-3
- Chemical Name:
- ZOSUQUIDAR TRIHYSROCHLORIDE
- Synonyms
- LY335979;Trihydrochloride;CS-58;D06387;RS 33295-198;LY335979) 3HCl;Zosuquidar HCl;Zosuquidr.3HCl;Zosuquidar 3HCl;Zosuquidar TriHCl
- CBNumber:
- CB81482979
- Molecular Formula:
- C32H32ClF2N3O2
- Molecular Weight:
- 564.07
- MDL Number:
- MFCD00942300
- MOL File:
- 167465-36-3.mol
- MSDS File:
- SDS
| Melting point | 172-176°C |
|---|---|
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Methanol (Slightly), Water (Slightly, Sonicated) |
| form | Solid |
| color | Pale Yellow to Light Yellow |
| NCI Dictionary of Cancer Terms | LY335979; zosuquidar trihydrochloride |
| FDA UNII | 813AGY3126 |
| NCI Drug Dictionary | zosuquidar trihydrochloride |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS05,GHS07,GHS02 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302+H312-H314-H226 | |||||||||
| Precautionary statements | P501-P270-P240-P210-P233-P243-P241-P242-P264-P280-P370+P378-P362+P364-P303+P361+P353-P301+P330+P331-P301+P312+P330-P304+P340+P310-P305+P351+P338+P310-P403+P235-P405 | |||||||||
| NFPA 704 |
|
ZOSUQUIDAR TRIHYSROCHLORIDE price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 21533 | Zosuquidar (hydrochloride) ≥98% | 167465-36-3 | 1mg | $38 | 2024-03-01 | Buy |
| Cayman Chemical | 21533 | Zosuquidar (hydrochloride) ≥98% | 167465-36-3 | 5mg | $120 | 2024-03-01 | Buy |
| Cayman Chemical | 21533 | Zosuquidar (hydrochloride) ≥98% | 167465-36-3 | 10mg | $201 | 2024-03-01 | Buy |
| Cayman Chemical | 21533 | Zosuquidar (hydrochloride) ≥98% | 167465-36-3 | 25mg | $456 | 2024-03-01 | Buy |
| Tocris | 5456 | Zosuquidartrihydrochloride ≥98%(HPLC) | 167465-36-3 | 50 | $844 | 2021-12-16 | Buy |
ZOSUQUIDAR TRIHYSROCHLORIDE Chemical Properties,Uses,Production
Chemical Properties
Pale Yellow Solid
Uses
Multi-drug resistance (MDR) modulator; selective inhibitor of P-glycoprotein (P-gp). Antineoplastic adjunct (chemosensitizer).
Biological Activity
ly335979 is a selective inhibitor of p-gp with ic50 value of 1.2 nm [1, 2].p-gp (p-glycoprotein) is a member of atp-binding cassette (abc) transporters and plays a pivotal role in pumping many foreign substances out of cells. it has been reported that abnormal expression of p-gp is correlated with the multidrug resistance of tumor cells [3].ly335979 is a potent p-gp inhibitor and has a different selectivity with the reported p-gp inhibitor cyclosporin a or verapamil. in drug-resistant cell line hl60/vcr with highly expression of p-gp, ly335979 exhibited highly restore ability of p-gp than cyclosporin a or verapamil and the ic 50 value of 1.2 nm [1]. when tested with a panel of cell lines over-expressed p-gp (cem/vlb100, mcf-7/adr, 2780ad, p388/adr, and ucla-p3.003vlb), administration of ly335979 reversed the cells resistance to vinblastine, doxorubicin, btoposide and taxol by inhibiting p-gp activity [2].in female nude mice model with ucla-p3.003vlb mdr tumor cells subcutaneous xenograft, pre-treated with ly335979 (30mg/kg) restored tumor cells sensitivity to taxol (20 mg/kg) which combination markedly suppressed solid tumor growth compared with control group [2].
storage
Store at -20°C
References
1. green, l.j., p. marder, and c.a. slapak, modulation by ly335979 of p-glycoprotein function in multidrug-resistant cell lines and human natural killer cells. biochem pharmacol, 2001. 61(11): p. 1393-9.2. dantzig, a.h., et al., reversal of p-glycoprotein-mediated multidrug resistance by a potent cyclopropyldibenzosuberane modulator, ly335979. cancer res, 1996. 56(18): p. 4171-9.3. hu, t., et al., reversal of p-glycoprotein (p-gp) mediated multidrug resistance in colon cancer cells by cryptotanshinone and dihydrotanshinone of salvia miltiorrhiza. phytomedicine, 2014. 21(11): p. 1264-72.
ZOSUQUIDAR TRIHYSROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29271 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
View Lastest Price from ZOSUQUIDAR TRIHYSROCHLORIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2020-01-10 | ZOSUQUIDAR TRIHYSROCHLORIDE
167465-36-3
|
US $0.50 / g | 1g | 98%min | 10g,100g,1kg | Career Henan Chemical Co |
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- ZOSUQUIDAR TRIHYSROCHLORIDE
167465-36-3
- US $0.50 / g
- 98%min
- Career Henan Chemical Co