6-THIO-2'-DEOXYGUANOSINE
- CAS No.
- 789-61-7
- Chemical Name:
- 6-THIO-2'-DEOXYGUANOSINE
- Synonyms
- tgdr;6-SH-dG;NSC-71261;6-Thio-dG;nci-c01581;Aids010571;Aids-010571;Thiodeoxyguanosine;6-Thio-dG (β-TGdR);6-SH-deoxyguanosine
- CBNumber:
- CB8152534
- Molecular Formula:
- C10H13N5O3S
- Molecular Weight:
- 283.31
- MDL Number:
- MFCD00672275
- MOL File:
- 789-61-7.mol
| Melting point | 190-192 °C |
|---|---|
| Boiling point | 709.1±70.0 °C(Predicted) |
| Density | 2.02±0.1 g/cm3(Predicted) |
| storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| solubility | DMSO (Slightly), DMF (Slightly), Methanol (Slightly, Heated), Water (Very Slightly) |
| form | Solid |
| pka | 6.81±0.20(Predicted) |
| color | Yellow to Brown |
| FDA UNII | KR0RFB46DF |
| NCI Drug Dictionary | beta-thioguanine deoxyriboside |
6-THIO-2'-DEOXYGUANOSINE price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 19154 | 6-thio-2′-Deoxyguanosine ≥98% | 789-61-7 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 19154 | 6-thio-2′-Deoxyguanosine ≥98% | 789-61-7 | 5mg | $93 | 2024-03-01 | Buy |
| Cayman Chemical | 19154 | 6-thio-2′-Deoxyguanosine ≥98% | 789-61-7 | 10mg | $122 | 2024-03-01 | Buy |
| Cayman Chemical | 19154 | 6-thio-2′-Deoxyguanosine ≥98% | 789-61-7 | 25mg | $290 | 2024-03-01 | Buy |
| TRC | D281650 | 2''-Deoxy-6-thioGuanosine | 789-61-7 | 10mg | $145 | 2021-12-16 | Buy |
6-THIO-2'-DEOXYGUANOSINE Chemical Properties,Uses,Production
Uses
Guanosine (G837900) derivative with cancer chemotherapeutic properties. It is involved in the inhibition of human RNase H-mediated RNA cleavage from DNA-RNA duplexes via incorporation into DNA.
Biological Activity
6-thio-dg is a nucleoside analogue [1], is a telomerase-mediated telomere disrupting compound [2]. it is an anti-cancer inhibitor [1]. cancer cells were very sensitive to 6-thio-dg with observed ic50 values ranging from 0.7-2.9 μm, depending on cell types [3].telomeres are found at the end of eukaryotic linear chromosomes. they are essential for genomic stability and chromosome maintenance [3].in hct116 human colon cancer cell line, treatment with 6-thio-dg made progressive telomere shortening independent of telomerase activity inhibition and induced telomere dysfunction. grn163l is a telomerase inhibitor. in hct116 cells, treatment with grn163l and 6-thio-dg together increased telomere shortening. within 1 week, 6-thio-dg killed most of hct116 cells and altered cellular morphology. normal bj fibroblast cells are telomerase silent. after 1 week, treatment with 6-thio-dg showed no effect on cell morphology. after long-term treatment with 6-thio-dg, no effect on telomere shortening was found [1].in murine mode with xenograft derived from a549 lung cancer cell line, as compared to controls, intraperitoneal injection with 2 mg/kg of 6-thio-dg every other day completely prevented progressive tumor growth. ki67 is a biomarker correlating with proliferation levels. compared to controls, 6-thio-dg decreased ki67 staining. treatment with 6-thio-dg through local injection resulted in even more dramatic decrease in the tumor growth rate compared to untreated controls [3].
References
[1]. mender i, gryaznov s, dikmen zg, et al. abstract lb-125: a novel telomerase inhibitor. cancer research, 2013, 73(8 supplement): lb-125-lb-125.
[2]. mender i, gryaznov s, shay jw. a novel telomerase substrate precursor rapidly induces telomere dysfunction in telomerase positive cancer cells but not telomerase silent normal cells. oncoscience, 2015, 2(8): 693.
[3]. mender i, gryaznov s, dikmen zg, et al. induction of telomere dysfunction mediated by the telomerase substrate precursor 6-thio-2-deoxyguanosine. cancer discovery, 2015, 5(1): 82-95.
6-THIO-2'-DEOXYGUANOSINE Preparation Products And Raw materials
6-THIO-2'-DEOXYGUANOSINE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| BOC Sciences | +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| NewCan Biotech Limited | +86-0571-86912261 +8613735419629 | sales@newcanbio.com | China | 10027 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +8618829768577 | gao490372054@gamil.com | China | 1250 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Hu Bei Jiutian Bio-medical Technology CO.,Ltd | 027-88013699 17354350817 | Ryan@jiutian-bio.com | China | 7433 | 58 |
| Henan Allgreen Chemical Co.,LTD | +86-37155567971 +86-13633837469 | info@allgreenchem.com | China | 5986 | 58 |
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