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2-Aminopyridine structure
Chemical Name:
2APY;NSC 431;AKOS 91158;AURORA KA-680;2-Pyridylamin;A-PYRIDYLAMINE;2-PYRIDYLAMINE;2-PYRIDINAMINE;-Aminopyridine;ɑ-Pyridylamine
Molecular Formula:
Formula Weight:
MOL File:

2-Aminopyridine Properties

Melting point:
59 °C
Boiling point:
204-210 °C(lit.)
1.0308 (estimate)
vapor pressure 
5 hPa (125 °C)
refractive index 
1.5560 (estimate)
Flash point:
198 °F
storage temp. 
Store below +30°C.
Crystalline Powder, Crystals or Flakes
6.82(at 20℃)
Cream to light yellow-beige
Characteristic odour
Water Solubility 
Slightly soluble. 1-5 g/100 mL at 19 ºC
Exposure limits
NIOSH REL: TWA 0.5 ppm (2 mg/m3), IDLH 5 ppm; OSHA PEL: 0.5 ppm; ACGIH TLV: TWA 0.5 ppm.
CAS DataBase Reference
504-29-0(CAS DataBase Reference)
EWG's Food Scores
NIST Chemistry Reference
EPA Substance Registry System
2-Aminopyridine (504-29-0)
  • Risk and Safety Statements
Signal word  Danger
Hazard statements  H320-H370-H301+H311-H315-H319-H335-H301-H312-H331-H401-H411
Precautionary statements  P280-P302+P352+P312-P305+P351+P338-P261-P301+P310-P312-P273-P280h-P309-P310-P260-P264-P270-P301+P310+P330-P302+P352+P312+P361+P364-P305+P351+P338+P337+P313-P307+P311-P405-P501
Hazard Codes  T,Xi
Risk Statements  21-25-36/37/38-23/24/25
Safety Statements  26-36/37/39-45-38-28B
RIDADR  UN 2671 6.1/PG 2
WGK Germany  3
RTECS  US1575000
Autoignition Temperature >630 °C
Hazard Note  Toxic/Irritant
HazardClass  6.1
PackingGroup  II
HS Code  29333999
Toxicity LD50 orally in Rabbit: 200 mg/kg

2-Aminopyridine price More Price(19)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.01113 2-Aminopyridine for synthesis 504-29-0 100 g $39.31 2021-03-22 Buy
Sigma-Aldrich 09340 2-Aminopyridine purum, ≥98.0% (NT) 504-29-0 250g $58 2021-03-22 Buy
Sigma-Aldrich 8.01113 2-Aminopyridine for synthesis 504-29-0 500 g $152.62 2021-03-22 Buy
Sigma-Aldrich 09340 2-Aminopyridine purum, ≥98.0% (NT) 504-29-0 50g $28.3 2021-03-22 Buy
TCI Chemical A0411 2-Aminopyridine >99.0%(GC)(T) 504-29-0 25g $15 2021-03-22 Buy

2-Aminopyridine Chemical Properties,Uses,Production

Chemical Properties

2-Aminopyridine is a flammable, colorless crystalline solid, or white leaflets or powder, or colorless liquid with a characteristic odor

Physical properties

Colorless to yellow crystals, leaflets, flakes, or powder with a characteristic odor. May darken after prolonged storage.


The main use of 2-aminopyridine is in manufacturing pharmaceuticals such as antihistamines.


Compound has been shown to reversibly block voltage-dependent potassium channels, and is also a common impurity from the synthesis of compounds found in hair dyes.
2-Aminopyridine is used primarily in the pharmaceutical industry as an intermediate in chemical synthesis.
2-Aminopyridine is a basic building block of several heterocyclic compounds and Schiff bases.
2-Aminopyridine (2AP) is a derivatizing agent which can be used as a fluorescent label for oligosaccharide detection, chromatographic separation, fluorometric or mass spectrometric analysis.
2AP and its derivatives are good candidates for antimicrobial, anticorrosion and molecular sensing applications.


Used to label neutral and acidic glycans for fluorescent and UV detection in HPLC.1
2-AP has also been used to derivatize sialyloligosaccharides for detection in FAB-MS.2
2-Aminopyridine has been used as a reactant in the synthesis of 2-(2-aminopyridinium)acetyl starch with antioxidant property.
It can also be used:
As a reactant in the synthesis of 3-aroylimidazopyridines from chalcones by aerobic oxidative amidation using copper acetate catalyst.
In the synthesis of crystalline Cu(II) complex, di-μ-(2-aminopyridine(N,N′))-bis[(2,6 pyridinedicarboxylate)aquacopper(II)] tetrahydrate using 2,6-pyridinedicarboxylic acid and Cu(CH3COO)2.H2O.
As an imprinting molecule for the preparation of poly(methacrylic acid–ethylene glycol dimethacrylate) polymer. It is packed in micro-column for selective solid phase extraction of 2-aminopyridine.
As a reactant in the synthesis of 2-aryl-3-(pyridin-2-yl)-1,3-thiazolidin-4-ones in the presence of Lewis acid catalysts.

Synthesis Reference(s)

The Journal of Organic Chemistry, 72, p. 4554, 2007 DOI: 10.1021/jo070189y
Tetrahedron Letters, 11, p. 3901, 1970

General Description

White powder or crystals or light brown solid.

Air & Water Reactions

Decomposes in air. Soluble in water.

Reactivity Profile

2-Aminopyridine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides. Reacts with oxidizing agents .



Health Hazard

2-Aminopyridine causes central nervous system effects.

Fire Hazard

2-Aminopyridine is combustible.

Safety Profile

Poison by ingestion, inhalation, subcutaneous, intravenous, and intraperitoneal routes. Toxic effects resemble strychnine poisoning. Human systemic effects by inhalation: somnolence, convulsions, and antipsychotic effects. Human central nervous system effects by inhalation. When heated to decomposition it emits highly toxic fumes of NOx,.

Potential Exposure

2-Aminopyridine is used in the manufacture of pharmaceuticals; especially antihistamines.


The LD50 in mice by intraperitoneal injection was 35 mg/kg; lethal doses in animals also produced excitement, tremors, convulsions and tetany.1 Fatal doses were readily absorbed through the skin. A 0.2 M aqueous solution dropped in a rabbit’s eye was only mildly irritating.
2-Aminopyridine was not mutagenic in a variety of Salmonella tester strains with or without metabolic activation.

Environmental Fate

Soil. When radio-labeled 4-aminopyridine was incubated in moist soils (50%) under aerobic conditions at 30 °C, the amount of 14CO2 released from an acidic loam (pH 4.1) and an alkaline, loamy sand (pH 7.8) was 0.4 and 50%, respectively (Starr and Cunningham, 1975).
Chemical/Physical. Releases toxic nitrogen oxides when heated to decomposition (Sax and Lewis, 1987).


UN2671 Aminopyridines, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

Purification Methods

It crystallises from *benzene/pet ether (b 40-60o) or CHCl3 /pet ether. [Beilstein 22/8 V 280.]


Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides

Waste Disposal

Incineration with nitrogen oxides removal from effluent gas.

2-Aminopyridine Preparation Products And Raw materials

Raw materials

Preparation Products

2-Aminopyridine Suppliers

Global( 491)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shaoxing Anpai Import & Export Co. Ltd
+86 575 82567070
+86 575 82893270 CHINA 299 58
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020-81716319; China 3245 55
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Wuhan Boyuan Import & Export Co., LTD
0311-89850048 China 299 58
Win-Win Chemical CO., Limited
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View Lastest Price from 2-Aminopyridine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-11-08 2-Aminopyridine
US $3.00 / KG 100g 99 3000KGS Wuhan wingroup Pharmaceutical Co., Ltd
2021-10-11 2-Aminopyridine
US $0.00 / Kg/Bag 1ASSAYS 99% 20ton Hebei Mojin Biotechnology Co., Ltd
2021-08-05 2-Aminopyridine
US $25.00 / KG 100ASSAYS 99.5% 100 mt Hebei Guanlang Biotechnology Co., Ltd.

2-Aminopyridine Spectrum

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