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Rutin

Rutin
Rutin structure
CAS No.
153-18-4
Chemical Name:
Rutin
Synonyms
RUTIN;MELIN;ELDRIN;rutozyd;Rutosid;BIRUTAN;Rutinum;oxyritin;rutabion;usafcf-5
CBNumber:
CB8153566
Molecular Formula:
C27H30O16
Formula Weight:
610.52
MOL File:
153-18-4.mol

Rutin Properties

Melting point:
195 °C (dec.)(lit.)
alpha 
D23 +13.82° (ethanol); D23 -39.43° (pyridine)
Boiling point:
576.13°C (rough estimate)
Density 
1.3881 (rough estimate)
refractive index 
1.7650 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,2-8°C
solubility 
pyridine: 50 mg/mL
Colour Index 
75730
form 
powder
pka
6.17±0.40(Predicted)
color 
yellow to green
Water Solubility 
12.5 g/100 mL
Merck 
8304
Substances Added to Food (formerly EAFUS)
RUTIN
CAS DataBase Reference
153-18-4(CAS DataBase Reference)
EWG's Food Scores
1
FDA UNII
5G06TVY3R7
ATC code
C05CA01,C05CA51
NIST Chemistry Reference
Flavone-3-rutinoside, 3,3',4',5,7-pentahydroxy(153-18-4)
EPA Substance Registry System
Rutin (153-18-4)
SAFETY
  • Risk and Safety Statements
Hazard Codes  Xn,Xi
Risk Statements  22-36/37/38
Safety Statements  24/25-36-26
WGK Germany  3
RTECS  VM2975000
8
HS Code  29381000
Toxicity LD50 i.v. in mice: 950 mg/kg (propylene glycol soln) (Harrison)

Rutin price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHL89270 Rutin phyproof Reference Substance 153-18-4 50mg $104 2021-03-22 Buy

Rutin Chemical Properties,Uses,Production

Description

Rutin is widely found in nature and is almost contained in all of the Rutaceae and Sectaceae plants, especially abundant in Rutaceae, Rutaceae, Epacridaceae of leguminous, buckwheat of Polygonaceae, Eulali of Hypericum, Berchemia polyphylla var. leioclada of Tetranychidae, and wild wutong leaves of thistle, which are also used as raw materials in rutin extraction. In addition, it also exists in the Ilex pubescens of Aquifoliaceae, Forsythia of Oleaceae, pagoda tree pod of Leguminosae, tobacco, jujube, apricots, flavedo, tomatoes, and other plants.
At present, rutin in China mainly extracted from the Sophora japonica Linn of leguminous, which is listed in top grade of Shen Nong’s Classic Materia Medica. In addition, tartary buckwheat, which is rich in rutin and flavonoids, is native to India and now produced in China’s northwest, southwest, north, south, and other places.

Chemical Properties

Pale-Yellow Crystalline Solid

Physical properties

Appearance: light yellow or yellow-green needle crystal or crystalline powder, tastes slightly bitter, usually contains three crystal water, melting point at 176– 178 °C. Solubility: Rutin is soluble in methanol, pyridine, alkaline solution, and boiling water and hardly soluble in cold water, chloroform, carbon disulfide, ether, benzene, and petroleum ether.

History

In the mid-1930s, Hungarian scientist Szent Gyorgy firstly separated the flavonoid mixture. After the German pharmacy firstly made it into ranosine in 1942, the concept of vitamin P has been established worldwide. Further study proved that rutin was the most important flavonoids of vitamin P. These compounds were certified to have effects on many diseases in medical.
Recently, the research of rutin mainly focuses on the extraction process improvement, pharmacological effects, and pharmacodynamics research, aiming at improvement of its bioavailability through the development of different dosage forms. As for the extraction process, new extraction and purification methods have been developed since the original alkali extraction acid precipitation method. These methods greatly improve its extraction efficiency and reduce cost, including hot water precipitation, hot water extraction with macroporous resin adsorbing purification, ultrasonic radiation, hot water extraction with alcohol precipitation, cold alkali percolation extraction with acid precipitation, continuous reflux extraction, ethanol extraction, supercritical CO2 extraction, and enzymatic hydrolysis .
In recent years, advanced rutin dosage forms, such as rutin cyclodextrin saturation, HPMC controlled release tablets, solid dispersion tablets, coprecipitate, and rutin effervescent particles, greatly improve the rutin dissolution rate and its bioavailability.

Uses

Found in many plants, especially the buckwheat plant. Identity with Ilixanthin. Capillary protectant. Rutin is colored brown by tobacco enzyme under experimental conditions.

Uses

antidiabetic, dipeptidyl peptidase–4 inhibitor

Uses

For nutritional product

Uses

rutin is described as helping to tighten and strengthen skin capillaries, and as such it could help prevent a couperose condition. It also demonstrates anti-oxidant properties. Rutin is a flavonoid found in rue leaves, buckwheat, and other plants.

Definition

ChEBI: A rutinoside that is quercetin with the hydroxy group at position C-3 substituted with glucose and rhamnose sugar groups.

Pharmacology

As a flavonoid substance, rutin has a significant protective effect on the cardiovascular system, including the endothelium-dependent vasodilation through NO-guanylate cyclase pathway, antagonization on platelet-activating factor (PAF), inhibition on subsequent reactions induced by PAF binding to its specific membrane receptor, and protection of myocardial cells .
Rutin also has good free radical scavenging effects. Studies showed that rutin and its derivatives had a strong free radical scavenging effect, of which rutin possessed the strongest antioxidant activity. Rutin removed superoxide anion and hydroxyl radicals, exerted a strong anti-lipid peroxidation, protected mitochondria, and enhanced the activity of superoxide dismutase (SOD).

Clinical Use

Rutin is mainly used for the adjuvant treatment of hypertension and treatment for the prevention of other bleedings due to lack of rutin, such as cerebral hemorrhage, retinal hemorrhage, purpura, acute hemorrhagic nephritis, chronic bronchitis, and abnormal blood osmolality, restoration of capillary elastic embolism, and also for the prevention and treatment of diabetes and hyperlipidemia . Troxerutin, the most important active ingredient in hydroxy rutin, is used in the treatment of varicose veins/venous disorders, hemorrhoids, lymphedema, and postoperative edema, treatment of thrombosis and cerebrovascular disease, and also in the treatment of diabetes and liver disease. Since rutin has a mild effect with low cost and less adverse reactions, especially its remarkable effect on acute cerebral infarction, it is of great worth on promotion and application of rutin .

Purification Methods

The vitamin crystallises from MeOH or water/EtOH, dry it in air, then dry it further for several hours at 110o or in high vacuum at 120o. It forms yellow crystals from EtOH/Me2CO/H2O (2:1:1). It has also been purified by passing (0.5g) through a Kieselgel column (30 x 5cm) with EtOAc/MeOH/H2O (100:20:15), and after 750mL have passed through, the yellow fraction of 250mL gives the glycoside (0.3g) on evaporation. [H.rhammer et al. Chem Ber 101 1183 1968, Marini-Bettòlo Gazz Chim Ital 80 631 1950, Beilstein 18/5 V 519.]

Rutin Preparation Products And Raw materials

Raw materials

Preparation Products


Rutin Suppliers

Global( 534)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shaanxi Pioneer Biotech Co., Ltd .
86-13259417953(Whatsapp/Wechat) 86-13259417953(Whatsapp)
029-84385017 sales@pioneerbiotech.com CHINA 3001 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58
Pharmyao, All for life--- A Specific Trading Platform For Reference Standard Material
13560473592 020-81716320
020-81716319 sales@pharmyao.com CHINA 173 58
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37122233
+86-21-37127788 Candy@bj-chem.com CHINA 497 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8909 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
02783214688 bruce@xrdchem.cn CHINA 567 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29954 58

View Lastest Price from Rutin manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-11-30 Rutin
153-18-4
US $50.00 / KG 1KG 95% 10000KG Baoji Guokang Bio-Technology Co., Ltd.
2021-11-17 Rutin 153-18-4
153-18-4
US $56.00 / g 1g ≥98% 1000.00 kgs NanJing Spring & Autumn Biological Engineering CO., LTD.
2021-10-20 rutin
153-18-4
US $50.00 / KG 1KG 99% 9000kg/per week Hebei Lingding Biological Technology Co., Ltd

Rutin Spectrum


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