TCPOBOP
- CAS No.
- 76150-91-9
- Chemical Name:
- TCPOBOP
- Synonyms
- TCPOBOP;3,3',5,5'-TETRACHLORIDE-BPB;TCPOBOP - CAS 76150-91-9 - Calbiochem;inhibit,Bcl-2 Family,TCPOBOP,Inhibitor;1,4-Bis(3,5-dichloro-2-pyridyloxy)benzene;1,4-BIS[2-(3,5-DICHLOROPYRIDYLOXY)]BENZENE;1,4-Bis(3,5-Dichloro-2-pyridinyloxy)benzene;3,3',5,5'-TETRACHLORIDE-BISPYRIDYLOXYBENZENE;1,4-Bis[(3,5-dichloropyridin-2-yl)oxy]benzene;3,3′,5,5′-Tetrachloro-1,4-bis(pyridyloxy)benzene
- CBNumber:
- CB8155924
- Molecular Formula:
- C16H8Cl4N2O2
- Molecular Weight:
- 402.06
- MDL Number:
- MFCD00057368
- MOL File:
- 76150-91-9.mol
- MSDS File:
- SDS
Boiling point | 444.8±45.0 °C(Predicted) |
---|---|
Density | 1.518±0.06 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | DMSO: >10 mg/mL |
form | solid |
pka | -0.52±0.10(Predicted) |
color | white |
Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 week. |
FDA UNII | P4R368GDD7 |
SAFETY
Risk and Safety Statements
Safety Statements | 22-24/25 |
---|---|
WGK Germany | 3 |
RTECS | UT7145000 |
TCPOBOP price More Price(19)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | T1443 | TCPOBOP ≥98% (HPLC), solid | 76150-91-9 | 5mg | $80.7 | 2024-03-01 | Buy |
Sigma-Aldrich | 580563 | TCPOBOP | 76150-91-9 | 25mg | $124.8 | 2024-03-01 | Buy |
Cayman Chemical | 14140 | TCPOBOP ≥95% | 76150-91-9 | 5mg | $44 | 2024-03-01 | Buy |
Cayman Chemical | 14140 | TCPOBOP ≥95% | 76150-91-9 | 10mg | $78 | 2024-03-01 | Buy |
Cayman Chemical | 14140 | TCPOBOP ≥95% | 76150-91-9 | 25mg | $151 | 2024-03-01 | Buy |
TCPOBOP Chemical Properties,Uses,Production
Description
TCPOBOP (76150-91-9) is an activator of the mouse constitutive androstane receptor (mCAR) and human Preganane X receptor.1 Tumor promoter of mouse hepatocarcinogenesis.
Uses
TCPOBOP is an agonist for mCAR, inducing cytochrome P450 monooxygenases and multidrug resistance and cenobiotic efflux proteins.
General Description
A highly potent inducer of phenobarbital-like class of cytochrome P450 (CYP) enzymes. A tumor promoter that induces hepatocyte proliferation, independent of the presence of cytokines or transcription factors. Activates orphan nuclear receptors mCAR (mouse constitutive androstane receptor) and hPXR (human pregane X receptor), but has little or no effect on hCAR and mPXR. Also suppresses the expression of multi-drug resistance genes mdr2 and mdr3 in mouse liver.
Biochem/physiol Actions
TCPOBOP enhances the nuclear receptor CAR transactivation of cytochrome P450 (CYP), as dose-dependent direct agonist of CAR. The most potent known member of the phenobarbital-like class of CYP-inducing agents.
References
1) Tzameli et al. (2000) The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR; Mol. Cell. Biol., 20 2951 2) Diwan et al. (1992) Tumor-promoting and hepatocarcinogenic effects of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) in DBA/2NCr and C57BL/6NCr mice and an apparent promoting effect on nasal cavity tumors but not on hepatocellular tumors in F344/NCr rats initiated with N-nitrosodiethylamine; Carcinogenesis, 13 1893
TCPOBOP Preparation Products And Raw materials
Raw materials
Preparation Products
TCPOBOP Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-400-6206333 18521732826 | market@aladdin-e.com | China | 25009 | 65 |
Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
Supplier | Advantage |
---|---|
ATK CHEMICAL COMPANY LIMITED | 60 |
TargetMol Chemicals Inc. | 58 |
InvivoChem | 58 |
Hangzhou MolCore BioPharmatech Co.,Ltd. | 58 |
LEAPCHEM CO., LTD. | 58 |
Aladdin Scientific | 58 |
BOC Sciences | 65 |
Shanghai Aladdin Bio-Chem Technology Co.,LTD | 65 |
Sigma-Aldrich | 80 |
EMMX Biotechnology LLC | 60 |