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Abacavir-d4

Abacavir-d4 Structure
Abacavir-d4 structure
CAS No.
1260619-56-4
Chemical Name:
Abacavir-d4
Synonyms
ABC-d4;Ziagen-d4;1592U89-d4;Abacavir-d4;Abacavir D4 HCl;Abacavir-d4;(1S,4R)-4-[2-AMino-6-(cyclopropylaMino-d4)-9H-purin-9-yl]-2-cyclopentene-1-Methanol;(1S,4R)-4-[2-Amino-6-[(cyclopropyl-d4)amino]-9H-purin-9-yl]-2-cycpentene-1-methanol;(1S-cis)-4-[2-AMino-6-(cyclopropylaMino-d4)-9H-purin-9-yl]-2-cyclopentene- 1-Methanol;((1S,4R)-4-(2-amino-6-((cyclopropyl-2,2,3,3-d4)amino)-9H-purin-9-yl)cyclopent-2-en-1-yl)methanol
CBNumber:
CB81565155
Molecular Formula:
C14H18N6O
Molecular Weight:
286.33232
MDL Number:
MFCD11977959
MOL File:
1260619-56-4.mol
Last updated:2023-06-08 09:03:01
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Abacavir-d4 Properties

Melting point 222-225°C
storage temp. -20°C Freezer
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
color Off-White to Light Beige
Stability Very Hygroscopic

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS08
Signal word  Warning
NFPA 704
0
2 0

Abacavir-d4 price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 30076 Abacavir-d4 1260619-56-4 500μg $117 2024-03-01 Buy
Cayman Chemical 30076 Abacavir-d4 1260619-56-4 1mg $222 2024-03-01 Buy
Usbiological 001009 Abacavir-d4 1260619-56-4 1mg $496 2021-12-16 Buy
American Custom Chemicals Corporation RDL0006640 ABACAVIR-D4 95.00% 1260619-56-4 1MG $779.63 2021-12-16 Buy
American Custom Chemicals Corporation RDL0006640 ABACAVIR-D4 95.00% 1260619-56-4 10MG $2194.5 2021-12-16 Buy
Product number Packaging Price Buy
30076 500μg $117 Buy
30076 1mg $222 Buy
001009 1mg $496 Buy
RDL0006640 1MG $779.63 Buy
RDL0006640 10MG $2194.5 Buy

Abacavir-d4 Chemical Properties,Uses,Production

Description

Abacavir-d4 is intended for use as an internal standard for the quantification of abacavir by GC- or LC-MS. Abacavir is a nucleoside analog and an inhibitor of HIV-1 reverse transcriptase (Ki = 2.1 μM for the wild-type enzyme). It inhibits replication of a variety of HIV-1 and HIV-2 strains, including strains resistant to 3''-azido-3''-deoxythymidine (zidovudine; ) or 2'',3''-dideoxyinosine (didanosine; ), in HeLa cells stably expressing CD4 (IC50s = 5.8-21 μM). Abacavir inhibits replication of eight HIV-1 clinical isolates in phytohemagglutinin-stimulated isolated human peripheral blood lymphocytes with a mean IC50 value of 0.26 μM. It inhibits hepatitis B virus (HBV) DNA synthesis in HepG2 cells (IC50 = 7 μM) and is also active against human cytomegalovirus (CMV) strain AD169 and the Petaluma strain of feline immunodeficiency virus (FIV) in plaque reduction assays (IC50s = 32 and 0.4 μM, respectively). Formulations containing abacavir have been used in the treatment of HIV infection.

Chemical Properties

White Solid

Uses

Abacavir-d4 is deuterium labeled Abacavir (A104990). Abacavir is a carbocyclic 2''-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.

Uses

A labelled nucleoside reverse transcriptase inhibitor (NRTI)

Abacavir-d4 Preparation Products And Raw materials

Raw materials

Preparation Products

Abacavir-d4 Suppliers

Global( 30)Suppliers
Supplier Tel Email Country ProdList Advantage
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32344 50
Clearsynth Labs Limited +91-22-26355700 info@clearsynth.com India 9685 58
Cato Research Chemicals Inc. 020-81960175 min.he@cato-chem.com China 1958 55
Shenzhen SUNGENING Bio-Medical Co., Ltd. 0755-28967200 13631290199 wxf@sungening.com China 9506 60
Shenzhen Polymeri Biochemical Technology Co., Ltd. +86-400-002-6226 13028896684 sales@rrkchem.com China 55717 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 8740 58
Nanjing Shizhou Biology Technology Co.,Ltd 17301488900 judy.xia@synzest.com China 13698 58
United States Biological -- sales@advtechind.com United States 6106 58
Supplier Advantage
Chemsky（shanghai）International Co.,Ltd. 50
Clearsynth Labs Limited 58
Cato Research Chemicals Inc. 55
Shenzhen SUNGENING Bio-Medical Co., Ltd. 60
Shenzhen Polymeri Biochemical Technology Co., Ltd. 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
Nanjing Shizhou Biology Technology Co.,Ltd 58
United States Biological 58

1260619-56-4(Abacavir-d4)Related Search:

Abacavir (1S–4R)-4-(2-amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol hydrochloride Abacavir Abacavir 5’-Phosphate 2-Cyclopentene-1-methanol, 4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-, (1R-cis)-
Abacavir Abacavir Carboxylate (1R,3S)-3-[2-AMino-6-(cyclopropylaMino)-9H-purin-9-yl]cyclopentaneMethanol 2-Amino-6-cyclopropylamino-9H-purine Abacavir 5'-Glucuronide
Abacavir (1S,4R)-(4-Aminocyclopent-2-enyl)methanol hydrochloride Abacavir Related CoMpound D trans-Abacavir Hydrochloride Abacavir sulfate
6-aminocarbovir Abacavir Impurity 1 Abacavir Impurity 6

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(1S,4R)-4-[2-Amino-6-[(cyclopropyl-d4)amino]-9H-purin-9-yl]-2-cycpentene-1-methanol Abacavir-d4 Ziagen-d4 (1S,4R)-4-[2-AMino-6-(cyclopropylaMino-d4)-9H-purin-9-yl]-2-cyclopentene-1-Methanol (1S-cis)-4-[2-AMino-6-(cyclopropylaMino-d4)-9H-purin-9-yl]-2-cyclopentene- 1-Methanol 1592U89-d4 ABC-d4 Abacavir-d4 Abacavir D4 HCl ((1S,4R)-4-(2-amino-6-((cyclopropyl-2,2,3,3-d4)amino)-9H-purin-9-yl)cyclopent-2-en-1-yl)methanol 1260619-56-4 C14H14N6OD4 C14H14D4N6O Bases & Related Reagents Intermediates & Fine Chemicals Isotope Labeled Compounds Nucleotides Isotope Labelled Compounds Pharmaceuticals