racFTY720 Phosphate
- CAS No.
- 402615-91-2
- Chemical Name:
- racFTY720 Phosphate
- Synonyms
- FTY720 Phosphate;FingoliMod phosphate;FTY-P;FTY720-P;FTY-P-d4;FTY720-P-d4;racFTY720 Phosphate;Fingolimod Impurity 12;FingoliMod phosphate D4;rac FTY720-d4 Phosphate
- CBNumber:
- CB81565180
- Molecular Formula:
- C19H34NO5P
- Molecular Weight:
- 387.45
- MDL Number:
- MFCD18251416
- MOL File:
- 402615-91-2.mol
- MSDS File:
- SDS
| Melting point | 122-124°C |
|---|---|
| Boiling point | 584.2±60.0 °C(Predicted) |
| Density | 1.172±0.06 g/cm3(Predicted) |
| storage temp. | Hygroscopic, -20°C Freezer, Under Inert Atmosphere |
| solubility | Chloroform : Methanol (Slightly, Heated), Methanol (Slightly, Heated) |
| pka | 1.73±0.10(Predicted) |
| form | Solid |
| color | White to Off-White |
| Stability | Hygroscopic |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301-H311-H331 |
| Precautionary statements | P261-P264-P270-P271-P280-P302+P352-P304+P340-P310-P330-P361-P403+P233-P405-P501 |
racFTY720 Phosphate price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 10008639 | FTY720 Phosphate ≥98% | 402615-91-2 | 1mg | $106 | 2024-03-01 | Buy |
| Cayman Chemical | 10008639 | FTY720 Phosphate ≥98% | 402615-91-2 | 5mg | $467 | 2024-03-01 | Buy |
| Cayman Chemical | 10008639 | FTY720 Phosphate ≥98% | 402615-91-2 | 10mg | $826 | 2024-03-01 | Buy |
| Cayman Chemical | 10008639 | FTY720 Phosphate ≥98% | 402615-91-2 | 25mg | $1805 | 2024-03-01 | Buy |
| Usbiological | 474100 | FTY720 Phosphate | 402615-91-2 | 100mg | $1253 | 2021-12-16 | Buy |
racFTY720 Phosphate Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
Labelled rac FTY720 (F805010). rac FTY720 is a sphingosine 1-phosphate receptor modular, ameliorates experimental autoimmune encephalomyelitis by inhibition of T cell infiltration.
Definition
ChEBI: Fingolimod phosphate is a primary amino compound that is fingolimod in which one on the hydroxy groups has been converted into its dihydrogen phosphate derivative. It is the active metabolite of fingolimod. It has a role as an antineoplastic agent, an immunosuppressive agent and a sphingosine-1-phosphate receptor agonist. It is a monoalkyl phosphate, a primary amino compound and a primary alcohol. It is functionally related to a fingolimod.
Biological Activity
fty720 is sphingosine-1-phosphate (s1p) receptors agonist [1]. fty720 is a novel immunomodulatory agent derived from isp-1 (myriocin), a fungal metabolite that exists in traditional chinese herbal medicine. in higher eukaryotes, s1p is the ligand for five g-protein-coupled receptors. these s1p receptors are differentially expressed and regulate vascular maturation, angiogenesis, cardiac development and immunity. s1p receptors are important for directed cell movement [2].
in vitro
the phosphorylated fty720 acted as agonist for a family of g protein-coupled receptors in vitro. fty720 inhibited sphingosine-1-phosphate lyase activity [3]. fty720 phosphate acted as a potent agonist at sphingosine-1-phosphate (s1p) receptors s1p1, s1p3, s1p4, and s1p5 with ic50 values of 0.2-6 nm [3].
in vivo
in a variety of transplant and autoimmune models, fty720 was efficacious without inducing a generalized immunosuppressed state. fty720 was effective in human kidney transplantation. fty720 elicited lymphopenia resulting from a reversible redistribution of lymphocytes from circulation to secondary lymphoid tissues by unknown mechanisms. in a rodent model of multiple sclerosis, the phosphorylated fty720 compound was a potent agonist at four s s1p receptors. phosphorylation of fty720 acted through sphingosine 1-phosphate signaling pathways to modulate chemotactic responses and lymphocyte trafficking [1]. fty720 was phosphorylated in vivo. in mice, treatment with fty720 inhibited tissue sphingosine-1-phosphate lyase activity, whereas lyase gene and protein expression were not significantly affected [3].
References
[1] brinkmann v, davis m d, heise c e, et al. the immune modulator fty720 targets sphingosine 1-phosphate receptors[j]. journal of biological chemistry, 2002, 277(24): 21453-21457.
[2] spiegel s, milstien s. sphingosine-1-phosphate: an enigmatic signalling lipid[j]. nature reviews molecular cell biology, 2003, 4(5): 397-407.
[3] bandhuvula p, tam y y, oskouian b, et al. the immune modulator fty720 inhibits sphingosine-1-phosphate lyase activity[j]. journal of biological chemistry, 2005, 280(40): 33697-33700.
racFTY720 Phosphate Preparation Products And Raw materials
Raw materials
Preparation Products
racFTY720 Phosphate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shochem(Shanghai) Co.,Ltd | 86-21-50800795 | info@shochem.com | CHINA | 288 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14336 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 | info@afinechem.com | CHINA | 15377 | 58 |
| China National Standard Pharmaceutical Corporation Limited | +8615391658522 | overseasales@yongstandards.com | China | 11927 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Zhengzhou Lingzhiyue Technology Co., LTD | 13783527580 13783527580 | 2423733192@qq.com | China | 4746 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94838 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
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