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Boc-Thr(Bzl)-OH

Boc-Thr(Bzl)-OH Structure
Boc-Thr(Bzl)-OH structure
CAS No.
15260-10-3
Chemical Name:
Boc-Thr(Bzl)-OH
Synonyms
PLIT-017;BOC-THR-OH;BOC-L-THR-OH;BOC-THR(BZL);BOC-THREONINE;BOC-L-THR(BZL);BOC-THR(BZL)-OH;Bor-Thr(Bz1)-OH;BOC-L-THR(BZL)-OH;BOC-Thr (Obzl) OH
CBNumber:
CB8164096
Molecular Formula:
C16H23NO5
Molecular Weight:
309.36
MDL Number:
MFCD00066062
MOL File:
15260-10-3.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:44
Product description Number Pack Size Price
Boc-Thr(Bzl)-OH Novabiochem? 8.53004 25g $182
Boc-Thr(Bzl)-OH Novabiochem? 8.53004 100g $566
Boc-Thr(Bzl)-OH Novabiochem® 8.53004 1 kg $2270
Boc-Thr(Bzl)-OH Novabiochem® 8.53004 1 kg $2270
Boc-Thr(Bzl)-OH ≥99.0% (T) 15405 5g $69
More product size
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Boc-Thr(Bzl)-OH Properties

Melting point 80-82 °C(lit.)
alpha 22 º (c=2 in 95% ethanol)
Boiling point 461.5±45.0 °C(Predicted)
Density 1.152±0.06 g/cm3(Predicted)
refractive index 16.5 ° (C=1, MeOH)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form powder to crystal
pka 3.50±0.10(Predicted)
color White to Almost white
optical activity [α]20/D +16.5±1°, c = 1% in methanol
BRN 3065591
InChI InChI=1S/C16H23NO5/c1-11(21-10-12-8-6-5-7-9-12)13(14(18)19)17-15(20)22-16(2,3)4/h5-9,11,13H,10H2,1-4H3,(H,17,20)(H,18,19)/t11-,13+/m1/s1
InChIKey CTXPLTPDOISPTE-YPMHNXCESA-N
SMILES C(O)(=O)[C@H]([C@H](OCC1=CC=CC=C1)C)NC(OC(C)(C)C)=O
CAS DataBase Reference 15260-10-3(CAS DataBase Reference)
EPA Substance Registry System L-Threonine, N-[(1,1-dimethylethoxy)carbonyl]-O-(phenylmethyl)- (15260-10-3)
UNSPSC Code 12352209
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Safety Statements  22-24/25
WGK Germany  3
TSCA  Yes
HS Code  2924 29 70
NFPA 704
1
1 0

Boc-Thr(Bzl)-OH price More Price(51)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.53004 Boc-Thr(Bzl)-OH Novabiochem? 15260-10-3 25g $182 2025-07-31 Buy
Sigma-Aldrich 8.53004 Boc-Thr(Bzl)-OH Novabiochem? 15260-10-3 100g $566 2025-07-31 Buy
Sigma-Aldrich 8.53004 Boc-Thr(Bzl)-OH Novabiochem® 15260-10-3 1 kg $2270 2025-07-31 Buy
Sigma-Aldrich 8.53004 Boc-Thr(Bzl)-OH Novabiochem® 15260-10-3 1 kg $2270 2025-07-31 Buy
Sigma-Aldrich 15405 Boc-Thr(Bzl)-OH ≥99.0% (T) 15260-10-3 5g $69 2022-05-15 Buy
Product number Packaging Price Buy
8.53004 25g $182 Buy
8.53004 100g $566 Buy
8.53004 1 kg $2270 Buy
8.53004 1 kg $2270 Buy
15405 5g $69 Buy

Boc-Thr(Bzl)-OH Chemical Properties,Uses,Production

Chemical Properties

White crystalline

Uses

Boc-O-benzyl-L-threonine, is an amino acid building block used in peptide synthesis. With a growing peptide drug market the fast, reliable synthesis of peptides is of great importance.

Application

Boc-Thr(Bzl)-OH is a standard building block for introduction of threonine amino-acid residues by Boc SPPS.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

Boc-L-Threonine

2592-18-9

Benzyl bromide

100-39-0

Boc-Thr(Bzl)-OH

15260-10-3

To a stirred solution of (2S,3R)-2-((tert-butoxycarbonyl)amino)-3-hydroxybutanoic acid (250 g, 1.44 mol) in DMF (1 L) was added 60% sodium hydride (68 g, 2.85 mol) in batches at -20 °C and protected by nitrogen and stirring was continued for 2 hours. Subsequently, benzyl bromide (167 mL, 1.36 mol) was slowly added dropwise and the reaction mixture was continued to be stirred at room temperature for 3 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming complete consumption of the raw materials, the reaction was quenched with ice water and subsequently washed with ether (2 x 250 mL). The aqueous layer was separated and the pH was adjusted to about 2 with citric acid solution, followed by extraction with ethyl acetate (2 x 300 mL). The organic layers were combined, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to afford (2S,3R)-3-(benzyloxy)-2-((tert-butoxycarbonyl)amino)butanoic acid (320 g, 90% yield) as a thick paste.1H-NMR (500 MHz, DMSO-d6) data: δ 12.64 (broad single peak, 1H), 7.34-7.25 (multiple peaks, 5H), and 6.46 (double peak, J=8.5Hz, 1H), 4.53 (double peak, J=11.5Hz, 1H), 4.39 (double peak, J=12.0Hz, 1H), 4.00-3.98 (multiple peaks, 2H), 1.39 (single peak, 9H), 1.15 (double peak, J=6.0Hz, 3H).

References

[1] Patent: WO2018/26763, 2018, A1. Location in patent: Page/Page column 63
[2] Patent: WO2014/120786, 2014, A1. Location in patent: Paragraph 0101
[3] Patent: WO2014/120783, 2014, A1. Location in patent: Paragraph 0093
[4] Patent: WO2017/195069, 2017, A1. Location in patent: Page/Page column 66
[5] Bulletin of the Chemical Society of Japan, 1995, vol. 68, # 5, p. 1369 - 1377

Boc-Thr(Bzl)-OH Preparation Products And Raw materials

Raw materials

L-Threonine 1,4-Dioxane Boc-L-Threonine Benzyl bromide Mineral oil
N,N-Dimethylformamide Sodium hydride

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Preparation Products

Boc-L-Threonine H-THR(BZL)-OH

Boc-Thr(Bzl)-OH Suppliers

Global( 323)Suppliers
Supplier Tel Email Country ProdList Advantage
Sichuan HongRi Pharma-Tech Co.,Ltd
+8617390183901 cynthia@enlaibio.com China 1100 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29735 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
AB PharmaTech,LLC 		323-480-4688 sales@acrospharmatech.com United States 989 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29850 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28172 58
Xiamen AmoyChem Co., Ltd 		+86-86-5926051114 +8615060885618 sales@amoychem.com China 6369 58
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22963 58
Shandong chuangyingchemical Co., Ltd. 		18853181302 sale@chuangyingchem.com CHINA 5906 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19552 58
Supplier Advantage
Sichuan HongRi Pharma-Tech Co.,Ltd
58
Capot Chemical Co.,Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
AB PharmaTech,LLC 		55
career henan chemical co 		58
Hubei Jusheng Technology Co.,Ltd. 		58
Xiamen AmoyChem Co., Ltd 		58
Hubei xin bonus chemical co. LTD 		58
Shandong chuangyingchemical Co., Ltd. 		58
BOC Sciences 		58

View Lastest Price from Boc-Thr(Bzl)-OH manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Boc-Thr(Bzl)-OH pictures 2025-11-03 Boc-Thr(Bzl)-OH
15260-10-3
 US $0.00 / Kg/Drum 1KG 98%min 500kgs WUHAN FORTUNA CHEMICAL CO., LTD
Boc-L-Thr(Bzl)-OH pictures 2025-11-03 Boc-L-Thr(Bzl)-OH
15260-10-3
 US $0.00-0.00 / kg 1kg 98% 1T+ Sichuan HongRi Pharma-Tech Co.,Ltd
Boc-O-Benzyl-L-Threonine pictures 2021-12-15 Boc-O-Benzyl-L-Threonine
15260-10-3
 US $10.00 / KG 1Kg/Bag 99% 20 Tons Hebei Zhanyao Biotechnology Co. Ltd
  • Boc-Thr(Bzl)-OH pictures
  • Boc-Thr(Bzl)-OH
    15260-10-3
  • US $0.00 / Kg/Drum
  • 98%min
  • WUHAN FORTUNA CHEMICAL CO., LTD

Boc-Thr(Bzl)-OH Spectrum

Boc-O-Benzyl-L-threonine(15260-10-3)MSBoc-O-Benzyl-L-threonine(15260-10-3)1HNMRBoc-O-Benzyl-L-threonine(15260-10-3)13CNMRBoc-O-Benzyl-L-threonine(15260-10-3)IR1Boc-O-Benzyl-L-threonine(15260-10-3)IR2

15260-10-3(Boc-Thr(Bzl)-OH)Related Search:

tert-Butyl peroxyacetate tert-Butanol L-Threonine Benzyl chloride Benzyl benzoate
Benzyl alcohol Benzyl isocyanate Benzyl nicotinate Benzyl N-tert-Butyloxycarbonyl-N-methyl-O-benzyl-L-threonine
N-ALPHA-T-BOC-O-BENZYL-D-THREONINE / (2R,3S),N-ALPHA-T-BOC-O-BENZYL-D-THREONINE,BOC-O-BENZYL-D-THREONINE Boc-L-Threonine BOC-THR(P-CHLORO-BZL)-OH DCHA BOC-L-THR(BZL)-O-CH2-PHI-CH2-COOH DCHA BOC-O-BENZYL-L-THREONINE N-CARBOXY ANHYDRIDE
BOC-O-BENZYL-L-THREONINE P-NITROPHENYL ESTER,BOC-O-BENZYL-L-THREONINE 4-NITROPHENYL ESTER BOC-THR(BZL)-OSU BOC-O-BENZYL-D-THREONINE 4-OXYMETHYLPHENYLACETAMIDOMETHYL RESIN,BOC-O-BENZYL-D-THREONINE MERRIFIELD RESIN

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N-TERT-BUTYLOXYCARBONYL-L-THREONINE N-(TERT-BUTOXYCARBONYL)-P-THREONINE N-(TERT-BUTOXYCARBONYL)-O-BENZYL-L-THREONINE N-ALPHA-TERT-BUTYLOXYCARBONYL-O-BENZYL-L-THREONINE N-ALPHA-TERT-BUTYLOXYCARBONYL-L-THREONINE N-ALPHA-TERT-BOC-O-BENZYL-L-THREONINE N-ALPHA-T-BUTOXYCARBONYL-L-THREONINE N-ALPHA-T-BUTOXYCARBONYL-O-BENZYL-L-THREONINE N-ALPHA-T-BOC-L-THREONINE N-ALPHA-T-BOC-O-BENZYL-L-THREONINE N-BOC-O-BENZYL-L-THREONINE BOC-L-THREONINE-OH BOC-L-THR-OH BOC-L-THREONINE (BZL) BOC-L-THR(BZL)-OH BOC-L-THR(BZL) BOC-THR-OH BOC-THR(BZL)-OH Butoxacarbonylbenzylthreonine Butoxycarbonylbenzylthreonine N-T-boc-O-benzyl-L-threonine*crystalline O-benzyl-N-tert-butoxycarbonyl-L-threonine N-ALPHA-T-BUTYLOXYCARBONYL-O-BENZYL-L-THREONINE NALPHA-tert-Butoxycarbonyl-O-benzyl-L-threonine BOC-Thr (Obzl) OH (2S,3R)-3-(benzyloxy)-2-((tert-butoxycarbonyl)aMino)butanoic acid (2S,3R)-2-[(2-Methylpropan-2-yl)oxycarbonylamino]-3-(phenylmethoxy)butanoic acid L-Threonine, N-[(1,1-dimethylethoxy)carbonyl]-O-(phenylmethyl)- Boc-O-Bzl-L-Thr-OH N-(tert-Butyloxycarbonyl)-O-benzyl-L-threonine N-[(1,1-Dimethylethoxy)carbonyl]-O-(phenylmethyl)-L-threonine Boc-O-benzyl-L-threonine, N-(tert-Butoxycarbonyl)-O-benzyl-L-threonine Boc-O-Benzyl-L-threo N-Boc-O-benzyl-L-threonine Boc-Thr(Bzl)-OH Bor-Thr(Bz1)-OH n-[(1,1-dimethylethoxy)carbonyl]-o-(phenylmethyl)-l-threonin TBOC-L-THREONINE (BZL) T-BUTYLOXYCARBONYL-O-BENZYL-L-THREONINE N-T-BUTOXYCARBONYL-L-THREONINE N-T-BUTOXYCARBONYL-O-BENZYL-L-THREONINE N-TERT-BUTOXACARBONYL-O-BENZYL-L-THREONINE BOC-O-BENZYL-L-THREONINE BOC-THR(BZL) BOC-THREONINE BOC-THREONINE(BZL)-OH Boc-O-benzyl-L-threonine≥ 99% (HPLC) 2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]-3-phenylmethoxybutanoate (Tert-Butoxy)Carbonyl Thr(Bzl)-OH PLIT-017 N-(tert-Butoxycarbonyl)-O-benzyl-L-threonine > (2S,3R)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylmethoxybutanoicaci Boc-O-Benzyl-L-threonine USP/EP/BP N-tert-Butoxycarbonyl-O-benzylthreonine 15260-10-3 C16H23NO5 CH3CHOCH2C6H5CHCOOHNHCOOCCH33 Amino Acid Derivatives Boc-Amino Acids