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Phenoxybenzamine hydrochloride

Phenoxybenzamine hydrochloride
Phenoxybenzamine hydrochloride structure
CAS No.
63-92-3
Chemical Name:
Phenoxybenzamine hydrochloride
Synonyms
688A;Bensylyt;benzylyt;SKF-688A;dibenylin;NSC 37448;nci-c01661;dibenzyran;dibenzyline;bensylytnen
CBNumber:
CB8172020
Molecular Formula:
C18H22ClNO.ClH
Formula Weight:
340.29
MOL File:
63-92-3.mol

Phenoxybenzamine hydrochloride Properties

Melting point:
137.5°C
storage temp. 
2-8°C
solubility 
H2O: slightly soluble
form 
powder
pka
pKa 4.4 (Uncertain)
color 
white
Water Solubility 
<0.01 g/100 mL at 18.5 ºC
Merck 
14,7256
CAS DataBase Reference
63-92-3(CAS DataBase Reference)
EPA Substance Registry System
Benzylamine, N-(2-chloroethyl)-N-(1-methyl- 2-phenoxyethyl)-, hydrochloride(63-92-3)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07,GHS08
Signal word  Warning
Hazard statements  H302-H351
Precautionary statements  P301+P312+P330-P280-P281-P301+P312a-P501a-P201-P202-P264-P270-P308+P313-P405-P501
Hazard Codes  Xn
Risk Statements  22-40
Safety Statements  22-36/37/39-45
WGK Germany  3
RTECS  DP3750000
HS Code  2922299000

Phenoxybenzamine hydrochloride price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich B019 Phenoxybenzamine hydrochloride ≥97%, powder 63-92-3 250mg $112 2018-11-13 Buy
Sigma-Aldrich 1526007 Phenoxybenzamine hydrochloride United States Pharmacopeia (USP) Reference Standard 63-92-3 250mg $348 2018-11-13 Buy
TCI Chemical D0158 Phenoxybenzamine Hydrochloride >98.0%(T) 63-92-3 1g $36 2018-11-22 Buy
TCI Chemical D0158 Phenoxybenzamine Hydrochloride >98.0%(T) 63-92-3 25g $335 2018-11-22 Buy
Alfa Aesar J61900 Phenoxybenzamine hydrochloride 63-92-3 1g $37.8 2018-11-13 Buy

Phenoxybenzamine hydrochloride Chemical Properties,Uses,Production

Chemical Properties

White Solid

Chemical Properties

White crystalline solid or powder. Odorless.

Uses

alpha adrenergic blocker

Uses

An irreversible α-antagonist. Used in the treatment of hypertension, it has a relatively slow onset and prolonged effect when compared to alternative α-blockers.

brand name

Dibenzyline (WellSpring).

General Description

White crystalline powder. Melting point 137.5-140°C. Used as an antihypertensive drug.

General Description

Phenoxybenzamine (Dibenzyline) an old but powerfulα-blocker, is a haloalkylamine that blocksα1- and α2-receptors irreversibly. Phenoxybenzamine administrationhas been described as producing a “chemical sympathectomy”because of its selective blockade of the excitatory responses of smooth muscle and of the heart muscle.Although phenoxybenzamine is capable of blockingacetylcholine, histamine, and serotonin receptors, itsprimary pharmacological effects, especially that of vasodilation,may be attributed to its α-adrenergic blockingcapability. As would be expected of a drug that producessuch a profound α-blockade, administration is frequentlyassociated with reflex tachycardia, increased cardiacoutput, and postural hypotension. There is also evidenceindicating that blockade of presynaptic 2-receptorscontribute to the increased heart rate produced byphenoxybenzamine.

Air & Water Reactions

Light sensitive and may be sensitive to exposure to air . Insoluble in water.

Fire Hazard

Flash point data are not available for Phenoxybenzamine hydrochloride , but Phenoxybenzamine hydrochloride is probably combustible.

Clinical Use

Oral phenoxybenzamine is used for the preoperativemanagement of patients with pheochromocytoma and in thechronic management of patients whose tumors are notamenable to surgery. Only about 20% to 30% of an oraldose is absorbed.

Safety Profile

Confumed carcinogen with experimental carcinogenic and teratogenic data. Poison by intraperitoneal,intravenous, and subcutaneous routes. Human systemic effects by ingestion: changes in tubules, including acute renal failure, acute tubular necrosis. Moderately toxic by ingestion. Other experimental reproductive effects. Mutation data reported. A long-acting adrenergic blocker. When heated to decomposition it emits very toxic fumes of NOx and Cl-.

Potential Exposure

Used as an antihypertensive drug

Veterinary Drugs and Treatments

Phenoxybenzamine is used in small animals primarily for its effect in reducing internal urethral sphincter tone in dogs and cats when urethral sphincter hypertonus is present. It can also be used to treat the hypertension associated with pheochromocytoma prior to surgery or as adjunctive therapy in endotoxicosis.
In horses, phenoxybenzamine has been used for preventing or treating laminitis in its early stages and to treat secretory diarrheas.

Carcinogenicity

Phenoxybenzamine hydrochloride is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

Shipping

UN3249 Medicine, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials

Incompatibilities

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Sensitive upon exposure to light and air. May form unstable and explosive peroxides upon standing.

Waste Disposal

Use a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed. It is inappropriate and possibly dangerous to the environment to dispose of expired or waste pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.

Regulations

Consumer Product Safety Commission (CPSC)
Any orally administered prescription drug for human use requires child-resistant packaging.
Food and Drug Administration (FDA)
Phenoxybenzamine hydrochloride is regulated as a prescription drug subject to labeling and other requirements.

Phenoxybenzamine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products


Phenoxybenzamine hydrochloride Suppliers

Global( 163)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30001 58
Jinan Jianfeng Chemical Co., Ltd
15562555968
info@pharmachemm.com CHINA 295 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23980 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 35440 58
Wuhan HongxinKang Fine Chemical Co., Ltd. 027-59362599 18674037007
027-84802889 zhuoxingwc@163.com China 939 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
TCI (Shanghai) Development Co., Ltd. 021-67121386 / 800-988-0390
021-67121385 Sales-CN@TCIchemicals.com China 24555 81
Energy Chemical 021-58432009 / 400-005-6266
021-58436166-800 info@energy-chemical.com China 44025 61
Beijing Ouhe Technology Co., Ltd +86-10-4006331231;+86-10-51280831;+86-10-82967028
+86-10-82967029 sales@ouhechem.com China 12495 60

View Lastest Price from Phenoxybenzamine hydrochloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-02 Phenoxybenzamine hydrochloride
63-92-3
US $100.00 / KG 1KG 99% Customized career henan chemical co

Phenoxybenzamine hydrochloride Spectrum


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