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Paroxetine hydrochloride

Paroxetine hydrochloride
Paroxetine hydrochloride structure
CAS No.
78246-49-8
Chemical Name:
Paroxetine hydrochloride
Synonyms
FG-7051;Deroxat;Seroxat;brl29060a;BRL-29060;(3s,4r)-orid;(3s-trans)-id;PAROXETINE HC;PAROXETINE HCL;PAROXETIN X HCL
CBNumber:
CB8178022
Molecular Formula:
C19H21ClFNO3
Formula Weight:
365.83
MOL File:
78246-49-8.mol

Paroxetine hydrochloride Properties

Melting point:
129-131°C
storage temp. 
2-8°C
form 
neat
CAS DataBase Reference
78246-49-8(CAS DataBase Reference)
NCI Dictionary of Cancer Terms
paroxetine hydrochloride
NCI Drug Dictionary
paroxetine hydrochloride
SAFETY
  • Risk and Safety Statements
RIDADR  3249
HazardClass  6.1(b)
PackingGroup  III
HS Code  29339900

Paroxetine hydrochloride price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHR1804 Paroxetine hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material 78246-49-8 500 mg $173 2021-03-22 Buy
Sigma-Aldrich Y0000578 Paroxetine hydrochloride (anhydrous) European Pharmacopoeia (EP) Reference Standard 78246-49-8 y0000578 $190 2020-08-18 Buy
Sigma-Aldrich 1500218 Paroxetine hydrochloride United States Pharmacopeia (USP) Reference Standard 78246-49-8 350 mg $366 2021-03-22 Buy
Cayman Chemical 14998 Paroxetine (hydrochloride) ≥98% 78246-49-8 10mg $39 2021-03-22 Buy
Cayman Chemical 14998 Paroxetine (hydrochloride) ≥98% 78246-49-8 25mg $93 2021-03-22 Buy

Paroxetine hydrochloride Chemical Properties,Uses,Production

Chemical Properties

White Crystalline Powder

Originator

Paxil, SmithKline Beecham ,France

Uses

Paroxetine is an antidepressant drug of the SSRI type

Uses

A selective serotonin reuptake inhibitor. Used as an antidepressant

Manufacturing Process

251 g of methyl-4-(4-fluorophenyl)-N-methyl-nipecotinate, 8 g of sodium methoxide and 500 ml benzene were refluxed for 2 h. The benzene solution was washed with cold water and evaporated to give the pure α-ester which was dissolved in a mixture of 320 ml of water and 450 ml concentrated hydrochloric acid. The solution was slowly distilled to remove methanol and finally evaporated to dryness in vacuo.
400 ml thionyl chloride were added in small portions to the solid. The mixture was allowed to stand for 3 h at room temperature and was then evaporated to dryness in vacuo with tetrachloroethane giving methyl-4-(4-fluorophenyl)-Nmethylnipecotic acid chloride. The acid chloride was added in small portions to a solution of 160 g (-)-menthol in 800 ml pyridine at a temperature of 0°-5°C. The mixture was allowed to stand at room temperature to the next day. Ice water and 50% sodium hydroxide were added, and the mixture was extracted with ether. The ether was dried with anhydrous magnesium sulphate, filtered and evaporated. Distillation in vacuo gave the menthol ester in a yield of 7580%. Boiling point at 0.05 mm Hg was 165°-170°C.
Racemic 4-(4-fluorophenyl)-1-methyl-1,2,3,6-tetrahydropyridine (50 g) was dissolved in a mixture of 21.6 ml of concentrated sulfuric acid and 50 ml of water. To the solution were added 25 ml of concentrated hydrochloric acid and 22.4 ml of 37% formaldehyde solution. The mixture was refluxed for 5 h, cooled, and 125 ml of concentrated ammonia were added. The mixture was extracted with 50 ml of toluene. Drying of the toluene solution and distillation gave 38 g of 4-(4-fluorophenyl)-3-hydroxymethyl-1-methyl-1,2,3,6tetrahydropyridine with boiling point 110°-120°C at 0.1 mm Hg.
13 g of the racemic compound and 22 g of (-)-dibenzoyltartaric acid were dissolved in 105 ml of hot methanol. On cooling, 9 g of salt of (-)-4-(4fluorophenyl)-3-hydroxymethyl-1-methyl-1,2,3,6-tetrahydropyridine crystallized. Melting point 167°-168°C.
38 g of (-)-4-(4-fluorophenyl)-3-hydroxymethyl-1-methyl-1,2,3,6tetrahydropyridine were dissolved in 350 ml of 99% ethanol, 5 g of 5% palladium on carbon were added, and the mixture was treated with hydrogen until 4500 ml were absorbed. The catalyst was filtered off, and the solution was evaporated to yield 37.5 g of (+)-b-4-(4-fluorophenyl)-3-hydroxymethyl1-methylpiperidine.
To a solution of sodium in methanol (125 ml) were added 3,4methylenedioxyphenol (29 g) and the (+)-b-4-(4-fluorophenyl)-3hydroxymethyl-1-methylpiperidine (37,5 g). The mixture was stirred and refluxed. After removal of the solvent in vacuo, the evaporation residue was poured into a mixture of ice (150 g), water (150 ml), and ether (200 ml). The ether layer was separated, and the aqueous layer was extracted with ether. The combined ether solutions were washed with water and dried with anhydrous magnesium sulphate, and the ether was evaporated. The residue was triturated with 200 ml of 99% ethanol and 11.5 ml of concentrated hydrochloric acid, yielding 30 g of (-)-b-4-(4-fluorophenyl-3-(1,3-benzdioxolyl(3)-oxymethyl)-1-methylpiperidine, hydrochloride were obtained. Melting point 202°C.

brand name

Paxil (GlaxoSmithKline).

Therapeutic Function

Antidepressant

Paroxetine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products


Paroxetine hydrochloride Suppliers

Global( 339)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 20012 60
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 20918 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Guangzhou PI PI Biotech Inc
+8618371201331
020-81716319 sales@pipitech.com;87478684@qq.com China 3245 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
02783214688 bruce@xrdchem.cn CHINA 567 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29954 58
Shaanxi Yikanglong Biotechnology Co., Ltd.
17791478691
yklbiotech@163.com CHINA 297 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
+86 0531-67809011 sales@sdzschem.com CHINA 2941 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6369 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23035 58

View Lastest Price from Paroxetine hydrochloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-11-26 Paroxetine hydrochloride
US $0.00 / KG 100g 98%+ 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
2021-11-26 Paroxetine hydrochloride
78246-49-8
US $0.00 / KG 100g 98%+ 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
2021-11-16 Paroxetine hydrochloride
78246-49-8
US $600.00 / KG 1g 99% 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD

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