Triethylenetetramine

Triethylenetetramine Properties

Melting point	12 °C(lit.)
Boiling point	266-267 °C(lit.)
Density	0.982 g/mL at 25 °C(lit.)
vapor density	~5 (vs air)
vapor pressure	<0.01 mm Hg ( 20 °C)
refractive index	n20/D 1.496(lit.)
Flash point	290 °F
storage temp.	Store below +30°C.
solubility	alcohol: soluble
pka	pK1:3.32(+4);pK2:6.67(+3);pK3:9.20(+2);pK4:9.92(+1) (20°C)
form	Slightly viscous yellow liquid; commercially available form is 95–98% pure, and impurities include linear, branched, and cyclic isomers.
color	Yellowish liquid or oil
PH	10-11 (10g/l, H2O, 20℃)
explosive limit	0.7-7.2%(V)
Water Solubility	SOLUBLE
FreezingPoint	12℃
Sensitive	Moisture Sensitive
Merck	14,9663
BRN	605448
Exposure limits	ACGIH: TWA 1 ppm (Skin) NIOSH: TWA 1 ppm(4 mg/m3)
Stability	Incompatible with strong oxidizing agents, strong acids.
LogP	-2.65 at 20℃
Indirect Additives used in Food Contact Substances	TRIETHYLENETETRAMINE
FDA 21 CFR	175.105; 175.300; 176.170; 176.180; 177.2600
CAS DataBase Reference	112-24-3(CAS DataBase Reference)
EWG's Food Scores	5
FDA UNII	SJ76Y07H5F
ATC code	A16AX12
NIST Chemistry Reference	Triethylenetetramine(112-24-3)
EPA Substance Registry System	Triethylenetetramine (112-24-3)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS07

Signal word

Danger

Hazard statements

H312-H314-H317-H412

Precautionary statements

P261-P272-P273-P280-P303+P361+P353-P305+P351+P338

Hazard Codes

C

Risk Statements

21-34-43-52/53

Safety Statements

26-36/37/39-45-61

RIDADR

UN 2259 8/PG 2

WGK Germany

2

RTECS

YE6650000

Autoignition Temperature

335 °C

TSCA

Yes

HazardClass

8

PackingGroup

II

HS Code

29212900

Toxicity

LD50 orally in rats: 2.5 g/kg (Spitz)

NFPA 704

	1
3		0

Triethylenetetramine price More Price(21)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	8.14392	Triethylenetetramine (mixture of isomers) for synthesis	112-24-3	100mL	$35.5	2024-03-01	Buy
Sigma-Aldrich	8.14392	Triethylenetetramine (mixture of isomers) for synthesis	112-24-3	500mL	$61.9	2024-03-01	Buy
Sigma-Aldrich	132098	Triethylenetetramine technical grade, 60%	112-24-3	1kg	$78.4	2024-03-01	Buy
Sigma-Aldrich	132098	Triethylenetetramine technical grade, 60%	112-24-3	2kg	$135	2024-03-01	Buy
TCI Chemical	T0429	Triethylenetetramine >60.0%(GC)	112-24-3	25mL	$22	2024-03-01	Buy

Product number	Packaging	Price	Buy
8.14392	100mL	$35.5	Buy
8.14392	500mL	$61.9	Buy
132098	1kg	$78.4	Buy
132098	2kg	$135	Buy
T0429	25mL	$22	Buy

Triethylenetetramine Chemical Properties,Uses,Production

Description

Cross sensitivity is possible with diethylenetriamine and diethylenediamine.

Chemical Properties

Triethylenetetramine is a corrosive liquid.

Uses

Triethylenetetramine is used in synthesis of detergents, softeners, and dyestuffs; manufacture of pharmaceuticals; vulcanization accelerator of rubber; thermo setting resin; epoxy curing agent; lubricating-oil additive; analytical reagent for Cu, Ni; chelating agent; treatment of Wilson's disease.

Uses

Triethylenetetramine is a selective CuII-chelator; crosslinking agent. Triethylenetetramine is undergoing trials for the treatment of heart failure in patients with diabetes.

Uses

Triethylenetetramine is used as an amine hardener in epoxy resin of the bisphenol A type.

Definition

ChEBI: 2,2,2-tetramine is a polyazaalkane that is decane in which the carbon atoms at positions 1, 4, 7 and 10 are replaced by nitrogens. It has a role as a copper chelator. It is a tetramine and a polyazaalkane.

Production Methods

TETA is manufactured by reacting ethylene dichloride and ammonia under controlled conditions.

brand name

Syprine (Merck).

Chemical Properties

Triethylenetetramine (TETA) is hygroscopic, corrosive, and has a strong ammoniacal odor. With water a crystalline hydrate is formed. Like DETA, it is completely miscible with water and many polar organic solvents, but less so with lipids; with CCl4 a violent reaction occurs. Its four pKa values are 3.32, 6.67, 9.20, and 9.92. Technical-grade TETA is sometimes available as a distillation cut that also contains branched isomers and cyclic compounds.

General Description

A yellowish liquid. Less dense than water. Combustible, though may be difficult to ignite. Corrosive to metals and tissue. Vapors heavier than air. Toxic oxides of nitrogen produced during combustion. Used in detergents and in the synthesis of dyes, pharmaceuticals and other chemicals.

Reactivity Profile

Triethylenetetramine is a strong base; reacts violently with strong oxidants; attacks aluminum, zinc, copper and its alloys. Handling Chemicals Safely 198. p. 934).

Health Hazard

Vapors from hot liquid can irritate eyes and upper respiratory system. Liquid burns eyes and skin. May cause sensitization of skin.

Fire Hazard

Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.

Flammability and Explosibility

Non flammable

Contact allergens

Triethylenetetramine is used as an amine hardener in epoxy resins of the bisphenol A type. Cross-sensitivity is possible with diethylenetriamine and diethylenediamine.

Safety Profile

Poison by intravenous route. Moderately toxic by ingestion and skin contact. An experimental teratogen. Experimental reproductive effects. Mutation data reported. A corrosive irritant to skin, eyes, and mucous membranes. Causes skin sensitization. Combustible when exposed to heat or flame. Ignites on contact with cellulose nitrate of high surface area. Can react with oxidizing materials. To fight fire, use CO2, dry chemical, alcohol foam. When heated to decomposition it emits toxic fumes of NOx.

Toxicology

Triethylenetetramine may induce lung edema on inhalation of its vapors. The compound is also an effective skin sensitizer. Following repeated dosing (ca. 50 mg each, 17 – 55 times) onto the skin of pregnant and nonpregnant guinea pigs, significant amounts were absorbed by the strongly irritated skin, leading to toxic effects in the kidneys, liver, brain, and placenta and causing abortion. Triethylenetetramine proved to be a mutagen in vitro but not in vivo.

Carcinogenicity

TETA was mutagenic in bacterial assays and was positive in sister chromatid exchanges and unscheduled DNA synthesis tests in vitro.8 It was not clastogenic in the mouse micronucleus test in vivo after oral or intraperitoneal administration.

Purification Methods

Dry the amine with sodium, then distil it under a vacuum. Further purification has been via the nitrate or the chloride salts. For example, Jonassen and Strickland [J Am Chem Soc 80 312 1958] separated TRIEN from admixture with TREN (38%) by solution in EtOH, cooling to approximately 5o in an ice-bath and adding conc HCl dropwise from a burette, keeping the temperature below 10o, until all of the white crystalline precipitate of TREN.HCl (see p 191) had formed and was removed. Further addition of HCl then precipitated thick, creamy white TRIEN.HCl (see below) which was crystallised several times from hot water by adding an excess of cold EtOH. The crystals were finally washed with Me2CO, then Et2O and dried in a vacuum desiccator. [Beilstein 4 H 255, 4 II 695, 4 III 542, 4 IV 1242.]

Triethylenetetramine Preparation Products And Raw materials

Raw materials

Ammonium hydroxide Ethylenediamine Diethylenetriamine 1,2-Dichloroethane Polyethylene-polyamines

Dichloroethane 1,4,7,10,13-Pentaazatridecane

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Preparation Products

1,1,4,7,10,10-HEXAMETHYLTRIETHYLENETETRAMINE Triethylenetetramine Dihydrochloride Diethylenetriamine triethylene tetraamine hexamethylene phosphoric acid TRIETHYLENETETRAMINE TETRAHYDROCHLORIDE

Triethylenediamine Piperazine-1,4-diethylamine 1-(2-Hydroxyethyl)-2-imidazolidinone 1-(2-Aminoethyl)imidazolidin-2-one 3H,6H-2a,5,6,8a-Tetraazaacenaphthylene, octahydro-5a,8b-dimethyl-, cis-

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Triethylenetetramine Suppliers

Global( 433)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
SyncoZymes (Shanghai) Co., Ltd.,	+8613681683526	llchen@syncozymes.com	China	40	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12453	58
Sinoway Industrial co., ltd.	0592-5800732; +8613806035118	xie@china-sinoway.com	China	992	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9350	55
Shanxi Naipu Import and Export Co.,Ltd	+86-13734021967 +8613734021967	kaia@neputrading.com	China	1011	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	+86 18953170293	sales@sdzschem.com	China	2931	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Hebei Guanlang Biotechnology Co., Ltd.	+86-19930503282	alice@crovellbio.com	China	8822	58

Supplier	Advantage
SyncoZymes (Shanghai) Co., Ltd.,	58
Hebei Mojin Biotechnology Co., Ltd	58
Sinoway Industrial co., ltd.	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
Shanxi Naipu Import and Export Co.,Ltd	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	58
Hubei Jusheng Technology Co.,Ltd.	58
Hebei Guanlang Biotechnology Co., Ltd.	58

View Lastest Price from Triethylenetetramine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-23	Triethylenetetramine 112-24-3	US $1.60 / kg	10kg	99%	300tons	Hebei Dangtong Import and export Co LTD
2024-04-22	Trientine 112-24-3	US $120.00-65.00 / Kg/Bag	10Kg/Bag	0.99	10 tons	Sinoway Industrial co., ltd.
2023-09-06	Triethylenetetramine 112-24-3	US $0.00 / KG	1KG	99%	500000kg	Hebei Guanlang Biotechnology Co., Ltd.

Triethylenetetramine
112-24-3
US $1.60 / kg
99%
Hebei Dangtong Import and export Co LTD

Trientine
112-24-3
US $120.00-65.00 / Kg/Bag
0.99
Sinoway Industrial co., ltd.

Triethylenetetramine
112-24-3
US $0.00 / KG
99%
Hebei Guanlang Biotechnology Co., Ltd.

Triethylenetetramine Spectrum

Triethylenetetramine(112-24-3)¹HNMR Triethylenetetramine(112-24-3)¹³CNMR Triethylenetetramine(112-24-3)IR1 Triethylenetetramine(112-24-3)Raman

112-24-3(Triethylenetetramine)Related Search:

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N,N,N',N'-Tetramethylethylenediamine Ethylenediamine Triethylenediamine

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N,N'-DI(2-AMINOETHYL)ETHYLENEDIAMINE N,N'-BIS(2-AMINOETHYL)ETHYLENEDIAMINE Ethylenediamine, N,N'-bis(2-aminoethyl)- hy951 n,n’-bis(2-aminoethyl)-2-ethanediamine N,N’-bis-(2-amino-ethyl)-ethane-1,2-diamine n,n’-bis(2-aminoethyl)-ethylenediamin N,N'-Bis(2-aminoethyl)-1,2-diaminoethane n,n-bis(2-aminoethyl)-1,2-diaminoethane TECZA Texacure EA-24 Texlin 300 Trientene Triethylenetetramine ,99.9% TriethylenetetraMine, 60% 500GR TriethylenetetraMine, 60% 50GR TRIETHYLENETETRAMINE (MIXTURE OF ISOMERS N1,N1'-(ethane-1,2-diyl)bis(ethane-1,2-diaMine) TETA)TriethylenetetraM 1,2-EthanediaMine,N1,N2-bis(2-aMinoethyl)- TriethylenetetraMine >=97.0% (T) TriethylenetetraMine technical grade, 60% TriethylenetetraMine, AR,70% EPH 925 Triethylenetetramine (Trientine) n,n'-bis(2-aminoethyl)-1,2-ethanediamine 3,6-DIAZAOCTANE-1,8-DIAMINE 1,8-diamino-3,6-diazaoctane 1,4,7,10-TETRAAZADECANE TRIETHYLENETETRAMINE 1,2-Ethanediamine, N,N'-bis(2-aminoethyl)- 1,2-Ethanediamine,N,N’-bis(2-aminoethyl)- 2-Ethanediamine,N,N’-bis(2-aminoethyl)-1 Araldite Hardener HY 951 Araldite HY 951 aralditehardenerhy951 aralditehy951 DEH 24 deh24 Ethanediamine, N,N'-bis(2-aminoethyl)- TRIETHYLENETETRAMINE, TECH., 60% TRIAETHYLENTETRAMINE Triethylenetetramine,Certified TriethyleneTetramineForSynthesis TRIETHYLENETETRAMINE,REAGENT TRIETHYLTETRAMINE Triethylentetramin TRIETHYLENETETRAMINE: TECH., 60%, BALANCE BRANCHED AND CYCLIC TRIETHYLENETETRAMINES LABOTEST-BB LTBB000434 Triethylenetetramine,95% Triethylenetetramine,60% 3,6-diazaoctanethylenediamin triethylenetetramine N,N-bis(Aminoethyl)ethylenediamine Triethylenetetramine(Technical) Triethylenetetramine > N,N-Di(2-Aminoethyl)Ethylenediamine,>70% Triethylenetetramine USP/EP/BP Triethylenetetramine (mix. of isomers) pure, 97%