ChemicalBook >> CAS DataBase List >>(R)-6,7-dimethoxy-4-(3-(quinoxalin-2-yloxy)pyrrolidin-1-yl)quinazoline
(R)-6,7-dimethoxy-4-(3-(quinoxalin-2-yloxy)pyrrolidin-1-yl)quinazoline
- CAS No.
- 927691-21-2
- Chemical Name:
- (R)-6,7-dimethoxy-4-(3-(quinoxalin-2-yloxy)pyrrolidin-1-yl)quinazoline
- Synonyms
- A844337;A-844337;A 844337;6,7-dimethoxy-4-[3-(2-quinoxalinyloxy)-1-pyrrolidinyl]quinazoline;6,7-dimethoxy-4-[(3R)-3-quinoxalin-2-yloxypyrrolidin-1-yl]quinazoline;6,7-Dimethoxy-4-[(3R)-3-(2-quinoxalinyloxy)-1-pyrrolidinyl]quinazoline;(R)-6,7-dimethoxy-4-(3-(quinoxalin-2-yloxy)pyrrolidin-1-yl)quinazoline;Quinazoline, 6,7-dimethoxy-4-[(3R)-3-(2-quinoxalinyloxy)-1-pyrrolidinyl]-;inhibit,Phosphodiesterase (PDE),PQ-10,Phosphodiesterase 10A,translational biomarker,schizophrenia,PQ10,PDE10A,glucose metabolism,Inhibitor,psychiatric disorders
- CBNumber:
- CB81876389
- Molecular Formula:
- C22H21N5O3
- Molecular Weight:
- 403.43
- MDL Number:
- MFCD12828216
- MOL File:
- 927691-21-2.mol
- MSDS File:
- SDS
Last updated:2023-06-08 09:03:09
| Density | 1.333 |
|---|---|
| storage temp. | 2-8°C |
| solubility | DMSO: soluble10mg/mL, clear |
| form | powder |
| color | white to beige |
| FDA UNII | 63643I762J |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
(R)-6,7-dimethoxy-4-(3-(quinoxalin-2-yloxy)pyrrolidin-1-yl)quinazoline price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1116 | PQ-10 ≥98% (HPLC) | 927691-21-2 | 25mg | $380 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML1116 | PQ-10 ≥98% (HPLC) | 927691-21-2 | 5mg | $107 | 2022-05-15 | Buy |
| Cayman Chemical | 21867 | PQ-10 ≥98% | 927691-21-2 | 1mg | $43 | 2024-03-01 | Buy |
| Cayman Chemical | 21867 | PQ-10 ≥98% | 927691-21-2 | 5mg | $106 | 2024-03-01 | Buy |
| Cayman Chemical | 21867 | PQ-10 ≥98% | 927691-21-2 | 10mg | $187 | 2024-03-01 | Buy |
(R)-6,7-dimethoxy-4-(3-(quinoxalin-2-yloxy)pyrrolidin-1-yl)quinazoline Chemical Properties,Uses,Production
Description
PQ-10 is a potent and selective inhibitor of phosphodiesterase type 10 (PDE10; Ki = 4 nM). It has >38-fold selectivity for PDE10 over a panel of 60 CNS-associated receptors, enzymes, and ion channels in vitro. Subcutaneous injection of PQ-10 (32 mg/kg) leads to increases in striatal cGMP and phosphorylation of cAMP response element binding protein (CREB) in murine striatum, known markers of in vivo PDE10 inhibition. PQ-10 at a dose of 0.3 mg/kg, p.o., reduces scopolamine- and MK-801-induced memory deficits in rats. PQ-10 also inhibits tumor cell growth with IC50 values of 0.29 and 0.22 mM for HCT116 and SW480 colon cancer cells, respectively.
Biochem/physiol Actions
PQ-10 is a potent and selective inhibitor of phosphodiesterase 10A (PDE10). Apparently, PQ-10 enhances basic auditory information processing in rats. PQ-10 as other PED10 inhibitors suppresses a growth of human non-small cell lung cancer (NSCLC) cell lines.
(R)-6,7-dimethoxy-4-(3-(quinoxalin-2-yloxy)pyrrolidin-1-yl)quinazoline Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 26)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| ZHIWE CHEMTECH CO LTD | 021-20221225 13917446399 | sales@zhiwe.net | China | 584 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | sales@capotchem.com | China | 18217 | 66 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4121 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
(R)-6,7-dimethoxy-4-(3-(quinoxalin-2-yloxy)pyrrolidin-1-yl)quinazoline
6,7-Dimethoxy-4-[(3R)-3-(2-quinoxalinyloxy)-1-pyrrolidinyl]quinazoline
6,7-dimethoxy-4-[(3R)-3-quinoxalin-2-yloxypyrrolidin-1-yl]quinazoline
6,7-dimethoxy-4-[3-(2-quinoxalinyloxy)-1-pyrrolidinyl]quinazoline
Quinazoline, 6,7-dimethoxy-4-[(3R)-3-(2-quinoxalinyloxy)-1-pyrrolidinyl]-
A 844337
A844337
A-844337
inhibit,Phosphodiesterase (PDE),PQ-10,Phosphodiesterase 10A,translational biomarker,schizophrenia,PQ10,PDE10A,glucose metabolism,Inhibitor,psychiatric disorders
927691-21-2
C22H21N5O3