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Fludarabine

CAS No. 21679-14-1
Chemical Name: Fludarabine
Synonyms: f-ara-a;Fludara;2-F-ARAA;NSC 118218;NSC-312887;NSC-328002;ludarabine;21697-14-1;FLUDARUBINE;FLUDARABINE
CBNumber: CB8188247
Molecular Formula: C10H12FN5O4
Formula Weight: 285.23
MOL File: 21679-14-1.mol
Fludarabine Property
Melting point : 265-268°C
storage temp. : 2-8°C
solubility : DMF: 20 mg/mL, clear, faintly yellow
Water Solubility : Soluble in DMF, DMSO, methanol or ethanol. Sparingly soluble in water
Merck : 13,4152
CAS DataBase Reference: 21679-14-1(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes : Xn
Risk Statements : 23/24/25-36/37/38-39/23/24/25-39-22
Safety Statements : 26-36/37-45
WGK Germany : 3
RTECS : AU6207000
F : 10
Hazardous Substances Data: 21679-14-1(Hazardous Substances Data)
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
Precautionary statements:

Fludarabine Chemical Properties,Usage,Production

Chemical Properties
White Solid
Uses
Used as an antineoplastic
Uses
A STAT-1 activation inhibitor and a DNA synthesis inhibitor.?
Uses
phosphate as antineoplastic;inhibits DNA synthesis by interfering with ribonucleotide reductase and DNA polymerase
Uses
Irreversible muscarinic agonist
Uses
DNA synthesis and methylation inhibitor;A cell permeable agent that interferes with DNA synthesis and repair; also inhibits RNA transcription
Biological Activity
Purine analog that inhibits DNA synthesis. Exhibits antiproliferative activity (IC 50 = 1.54 μ M in RPMI cells) and triggers apoptosis through increasing Bax and decreasing Bid, XIAP and survivin expression. Displays anticancer activity against hematological malignancies in vivo .
Fludarabine Preparation Products And Raw materials
Raw materials
2,4,5,6-TETRAAMINOPYRIMIDINE 2,6-Diaminopurine 2-(5-methyl-2-propan-2-yl-phenoxy)ethanamine Acetic anhydride DIACETAMIDE Fluoroboric acid Boron trichloride
Preparation Products
Fludarabine Suppliers      Global( 257)Suppliers     
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd. 0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3230 55
Shanghai YuLue Chemical Co., Ltd. 021-13671753212 13917602471 021-60345187
021-34702061 lzz841106@aliyun.com China 9995 55
Hongene Biotechnology Limited 86-21-64757213
86-21-64700613 info@hongene.com; sales@hongene.com China 437 61
Wuhu Nuowei chemistry Co., Ltd. 0553-2911116 18055311600
0553-2911116 salesnuowei@163.com China 1036 55
Target molecule Corp. 857-239-0968
857-239-8801 market@targetmol.com United States 2567 60
ShangHai Wisacheam Pharmaceutical Co., Ltd. 13817485796 13122608669 QQ:895624079
021-20422036 tim@wisacheampharm.com China 3681 58
Fujian South Pharmaceutical Co., Ltd. +86-598-2817680 13358505380
+86-598-2860416 sales@southpharma.com China 64 55
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96831 76
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037
86-21-50328109 3bsc@sina.com China 15950 69
Chembest Research Laboratories Limited +86(0)21-20908456
+86(0)21-58180499 sales@biochembest.com; market@biochembest.com China 6042 61
 
21679-14-1(Fludarabine)Related Search:
Temozolomide Gemcitabine hydrochloride Fludarabine Phosphate α-Chloropropionyl Chloride Flufenacet 6-AMINO-2-FLUORO-9-(2,3,5-TRI-O-BENZYL-BETA-D-ARABINOFURANOSYL)-9H-PURINE 2-FLUORO-6-(1,2,4-TRIAZOL-1-YL)-9-(5-O-PHOSPHONO-BETA-D-ARABINOFURANOSYL)-9H-PURINE 2-Fluoro-9-β-D-(2',3',5'-tri-O- acetyl arabinofuranosyl)-adenine 6-BENZYLOXYAMINO-9-(5-O-DIPHENYLPHOSPHONO-BETA-D-ARABINOFURANOSYL)-2-FLUORO-9H-PURINE 2-FLUOROADENINE-BETA-D-ARABINOFURANOSIDE, [8-3H]- FLUDARABINE PHOSPHATE (FLUDARABINE 5''-MONOPHOSPHATE),fludarabine hcl,FLUDARABINE PHOSPHATE 2-FLUORO-6-(1,2,4-TRIAZOL-1-YL)-9-(BETA-D-ARABINOFURANOSYL)-9H-PURINE 2-FLUOROADENINE-BETA-D-ARABINOFURANOSIDE 5'-MONOPHOSPHATE, DIAMMONIUM SALT, [8-3H]- Flutamide Danazol Tadalafil Triflusulfuron-methyl FLUMIOXAZIN Flumetralin
2-Fluoroadeninearabinoside 9-beta-d-arabinofuranosyl-2-fluoro-9h-purin-6-amin 9-beta-d-arabinofuranosyl-2-fluoro-adenin f-ara-a 6-AMINO-9 BETA-D-ARABINOFURANOSYLFLUOROPURINE 9-bata-d-arabinofuranosyl-2-fluoroadenine 9-BETA-D-ARABINOFURANOSYL-2-FLUORO-9H-PURIN-6-AMINE 9-BETA-D-ARABINOFURANOSYL-2-FLUOROADENINE 9-D-ARUBINOFURANOSYL-2-FLUORO-9H-PURIN-6-AMINE 21679-14-1 2-F-ARAA 2-FLUORO-9-ARABINOADENINE 2-fluoroadenine-9-bata-d-arabinofuranoside 2-FLUOROADENINE 9-BETA-D-ARABINOFURANOSIDE Antitumor Agents Cancer Research BioChemical Biochemicals and Reagents FLUDARUBINE FLUDARABINE FLUDARABINE BASE FLUDARABINE DES-PHOSPHATE DNA Synthesis Inhibitors Nucleoside Analogs Nucleosides, Nucleotides, Oligonucleotides 2-FLUOROADENINE 9-B-D-ARABINOFURANOSIDE 2-FLUOROADENINE-9-BETA-D-ARABINOFURANO-& Fludarabine&Int. ARABINOFURANOSYL-2-FLUOROADENINE 9-b-D-Arabinofuranosyl-2-fluoro-9H-purin-6-amine, 2-F-araA 9H-Purin-6-amine, 9-b-D-arabinofuranosyl-2-fluoro- 2-fluoroadenine-9-β-d-arabinofuranoside 9-β-d-arabinofuranosyl-2-fluoroadenine 2-Fluoro-9-arabinoadenine (Fludarabine) Fludarabine(TABINS) FLUDARABINE [2-FLUOROADENINE-9-BETA-D-ARABINOFURANOSIDE] 2-FLUORO-9-β-D-ARABINOFURANOSYLADENINE (FLUDARABINE: F-ARA-A) FLUDARABINE BASE :9-D-ARUBINOFURANOSYL-2-FLUORO-9H-PURIN-6-AMINE 2-Fluoro-9--D-arabinofuranosyladenine 9--D-Arabinofuranosyl-2-fluoro-9H-purin-6-amine NSC 118218 NSC 118218H Intermediates & Fine Chemicals Pharmaceuticals 9-β-D-Arabinofuranosyl-2-fluoroadenine, F-ara-A, Fludarabine des-phosphate 2-F-ara-Amp 9-β-D-Arabinohanosyl-2-fluo-roadenine Fludara NSC-312887 NSC-328002 (2R,3S,4S,5R)-2-(6-Amino-2-fluoropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol LUDARABINE BASE Fludarabine(Fludara) (2R,3S,4S,5R)-2-(6-aMino-2-fluoro-9H-purin-9-yl)-5-(hydroxyMethyl)-tetrahydrofuran-3,4-diol {[(2R,3S,4S,5R)-5-(6-aMino-2-fluoro-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]Methoxy}phosphonic acid Fludarabine API API Fludarabine (IMpurity E)
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