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Fludarabine

Fludarabine
Fludarabine structure
CAS No.
21679-14-1
Chemical Name:
Fludarabine
Synonyms
f-ara-a;Fludara;CS-1983;2-F-ARAA;NSC 118218;NSC-312887;NSC-328002;ludarabine;21697-14-1;Fludarbine
CBNumber:
CB8188247
Molecular Formula:
C10H12FN5O4
Formula Weight:
285.23
MOL File:
21679-14-1.mol

Fludarabine Properties

Melting point:
265-268°C
alpha 
D25 +17 ±2.5° (c = 0.1 in ethanol)
Boiling point:
747.3±70.0 °C(Predicted)
Density 
2.17±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMF: 20 mg/mL, clear, faintly yellow
pka
13.05±0.70(Predicted)
form 
Powder
color 
White to Pale Yellow
Water Solubility 
Soluble in DMF, DMSO, methanol or ethanol. Sparingly soluble in water
Merck 
13,4152
BRN 
1225932
CAS DataBase Reference
21679-14-1(CAS DataBase Reference)
FDA UNII
P2K93U8740
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Hazard Codes  Xn
Risk Statements  23/24/25-36/37/38-39/23/24/25-39-22
Safety Statements  26-36/37-45-36
WGK Germany  3
RTECS  AU6207000
10
HS Code  29349990

Fludarabine price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich F2773 2-Fluoroadenine-9-β-D-arabinofuranoside DNA synthesis and methylation inhibitor 21679-14-1 5mg $128 2019-12-02 Buy
Sigma-Aldrich F2773 2-Fluoroadenine-9-β-D-arabinofuranoside DNA synthesis and methylation inhibitor 21679-14-1 10mg $230 2019-12-02 Buy
Alfa Aesar J65562 2-Fluoro-9-beta-D-arabinofuranosyladenine, 98% 21679-14-1 1g $55.7 2020-06-24 Buy
Cayman Chemical 14128 Fludarabine ≥98% 21679-14-1 5mg $25 2020-06-24 Buy
Cayman Chemical 14128 Fludarabine ≥98% 21679-14-1 10mg $43 2020-06-24 Buy

Fludarabine Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

Used as an antineoplastic

Uses

A STAT-1 activation inhibitor and a DNA synthesis inhibitor.?

Uses

phosphate as antineoplastic;inhibits DNA synthesis by interfering with ribonucleotide reductase and DNA polymerase

Uses

Irreversible muscarinic agonist

Uses

DNA synthesis and methylation inhibitor;A cell permeable agent that interferes with DNA synthesis and repair; also inhibits RNA transcription

Indications

Fludarabine (Fludara) is a fluorinated purine analogue of the antiviral agent vidarabine.The active metabolite, 2-fluoro-ara-adenosine triphosphate, inhibits various enzymes involved in DNA synthesis, including DNA polymerase-α, ribonucleotide reductase, and DNA primase. Unlike most antimetabolites, it is toxic to nonproliferating as well as dividing cells, primarily lymphocytes and lymphoid cancer cells.
The drug is highly active in the treatment of chronic lymphocytic leukemia, with approximately 40% of patients achieving remissions after previous therapy with alkylating agents has failed. Activity is also seen in the low-grade lymphomas.
The major side effect is myelosuppression, which contributes to fevers and infections in as many as half of treated patients. Nausea and vomiting are mild. Occasional neurotoxicity has been noted at higher doses, with agitation, confusion, and visual disturbances.

General Description

The drug is available as the phosphate salt in a 50-mg vialfor IV use. Fludarabine is used to treat chronic lymphocyticleukemia and non-Hodgkin’s lymphoma. The mechanism ofaction involves the triphosphate metabolite and its inhibitionof DNA chain elongation. The 2-fluoro group on the adeninering renders fludarabine resistant to breakdown byadenosine deaminase. The drug is rapidly dephosphorylatedto 2-fluoro-ara-adenosine (F-ara-A) after administration. Fara-A is taken into the cell and subsequently re-phosphorylatedto yield the triphosphate (F-ara-ATP), the active drugspecies. Resistance can occur via decreased expression ofthe activating enzymes and decreased drug transport.Fludarabine is orally bioavailable and is distributed throughoutthe body reaching high levels in liver, kidney, andspleen. The drug is metabolized to F-ara-A, which enterscells via the nucleoside transport system and is rephosphorylatedby deoxycytidine kinase to fludarabine monophosphateand finally fludarabine triphosphate, the activespecies. About 25% of F-ara-A is excreted unchanged inurine. Drug interactions include an increased incidence offatal pulmonary toxicity when fludarabine is used in combinationwith pentostatin. Additionally, fludarabine may potentiate the effects of several other anticancer drugs includingcytarabine, cyclophosphamide, and cisplatin.Toxicities include myelosuppression, immunosuppression,fever, nausea, and vomiting.

Biological Activity

Purine analog that inhibits DNA synthesis. Exhibits antiproliferative activity (IC 50 = 1.54 μ M in RPMI cells) and triggers apoptosis through increasing Bax and decreasing Bid, XIAP and survivin expression. Displays anticancer activity against hematological malignancies in vivo .

Fludarabine Preparation Products And Raw materials

Raw materials

Preparation Products


Fludarabine Suppliers

Global( 350)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21838 58
Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
+86-10-60279497 sales01@cooperate-pharm.com CHINA 1817 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22625 55
Hangzhou FandaChem Co.,Ltd.
0086 158 5814 5714 (Mobile
+86-571-56059825 fandachem@gmail.com CHINA 3269 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
02783214688 bruce@xrdchem.cn CHINA 568 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24754 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30043 58
Shenzhen Nexconn Pharmatechs Ltd
15013857715
admin@nexconn.com CHINA 3000 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23977 58
QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409 orders@qcchemical.com United States 8406 58

View Lastest Price from Fludarabine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-08-26 Fludarabine
21679-14-1
US $0.00-0.00 / KG 1g 99.0% 50kg/month Beijing Yibai Biotechnology Co., Ltd
2020-04-29 Fludarabine
21679-14-1
US $0.00-0.00 / 公斤 1KG 99.0%+ 800 tons Shaanxi Dideu Medichem Co. Ltd
2018-08-15 Fludarabine
21679-14-1
US $1.00 / KG 1KG 99% 1000KG career henan chemical co

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