ChemicalBook >> CAS DataBase List >>N-DESMETHYLCLOZAPINE
N-DESMETHYLCLOZAPINE
- CAS No.
- 6104-71-8
- Chemical Name:
- N-DESMETHYLCLOZAPINE
- Synonyms
- NORCLOZAPINE;Desmethylclozapine;Norclozapine (ACP-104);Normethylclozapine;N-DESMETHYLCLOZAPINE;Clozapine EP IMpurity C;Clozapine Impurity C（EP）;N-Desmethylclozapine solution;Norclozapine Solution, 100ppm;Desmethylclozapine (Norclozapine)
- CBNumber:
- CB8196019
- Molecular Formula:
- C17H17ClN4
- Molecular Weight:
- 312.8
- MDL Number:
- MFCD00210189
- MOL File:
- 6104-71-8.mol
Last updated:2023-09-20 16:43:00
| Melting point | 120-125°C |
|---|---|
| Boiling point | 502.6±60.0 °C(Predicted) |
| Density | 1.38±0.1 g/cm3(Predicted) |
| Flash point | 9℃ |
| storage temp. | Store at RT |
| solubility | Chloroform (Slightly), DMSO, Methanol (Slightly) |
| pka | 8.49±0.10(Predicted) |
| form | Yellow solid. |
| color | Light Yellow to Yellow |
| CAS DataBase Reference | 6104-71-8(CAS DataBase Reference) |
| FDA UNII | 1I9001LWY8 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H332-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P301+P312-P302+P352-P304+P340+P312-P305+P351+P338 | |||||||||
| Hazard Codes | Xn,T,F | |||||||||
| Risk Statements | 20/22-36/37/38-39/23/24/25-23/24/25-11 | |||||||||
| Safety Statements | 22-36-45-36/37-16-7 | |||||||||
| RIDADR | 3249 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| NFPA 704 |
|
N-DESMETHYLCLOZAPINE price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | D5676 | N-Desmethylclozapine | 6104-71-8 | 5mg | $160 | 2024-03-01 | Buy |
| Sigma-Aldrich | D-048 | N-Desmethylclozapine solution 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant? | 6104-71-8 | 1mL | $163 | 2024-03-01 | Buy |
| Cayman Chemical | 26153 | N-Desmethylclozapine | 6104-71-8 | 5mg | $92 | 2024-03-01 | Buy |
| Cayman Chemical | 26153 | N-Desmethylclozapine | 6104-71-8 | 100mg | $1078 | 2024-03-01 | Buy |
| Sigma-Aldrich | D5676 | N-Desmethylclozapine | 6104-71-8 | 10mg | $237 | 2024-03-01 | Buy |
N-DESMETHYLCLOZAPINE Chemical Properties,Uses,Production
Chemical Properties
Yellow Crystalline Solid
Uses
A major metabolite of Clozapine. A potent and selective 5-HT2C serotonin receptor antogonist.
Uses
N-Desmethylclozapine has been used as standard to quantify the clozapine plasma levels in treatment-refractory Chinese schizophrenic patients.
Uses
A major metabolite of Clozapine (C587500). A potent and selective 5-HT2C serotonin receptor antogonist.
Definition
ChEBI: A dibenzodoazepine substituted with chloro and piperazino groups which is a major metabolite of clozapine; a potent and selective 5-HT2C serotonin receptor antagonist.
General Description
N-Desmethylclozapine is an active metabolite of Clozapine, an atypical antipsychotic drug used for treatment of schizophrenia. Clozapine is sold under the trade names Clozaril? and FrazaClo in the US. This Certified Snap-N-Spike? Solution is suitable for use in urine drug testing, clinical toxicology, forensic analysis, and clinical monitoring by LC-MS/MS or GC/MS.
Biological Activity
A major metabolite of clozapine; a potent and selective 5-HT 2C serotonin receptor antagonist.
Biochem/physiol Actions
N-Desmethylclozapine serves as an agonist to muscarinic acetylcholine receptors, and is known to exert its antipsychotic action. It blocks synaptic transmission by antagonizing synaptic GABA (γ-aminobutyric acid) receptors.
storage
Room temperature
Synthesis of N-DESMETHYLCLOZAPINE from Piperazine and 8-Chloro-5,10-dihydrodibenzo[b,e][1,4]diazepin-11-one
N-DESMETHYLCLOZAPINE Preparation Products And Raw materials
Global( 127)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14336 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9702 | 58 |
| sgtlifesciences pvt ltd | +8617013299288 | dj@sgtlifesciences.com | China | 12382 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Supplier | Advantage |
|---|---|
| Capot Chemical Co.,Ltd. | 60 |
| ATK CHEMICAL COMPANY LIMITED | 60 |
| Standardpharm Co. Ltd. | 58 |
| career henan chemical co | 58 |
| Finetech Industry Limited | 58 |
| sgtlifesciences pvt ltd | 58 |
| InvivoChem | 58 |
| TargetMol Chemicals Inc. | 58 |
| LEAPCHEM CO., LTD. | 58 |
| Aladdin Scientific | 58 |
View Lastest Price from N-DESMETHYLCLOZAPINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-03 | N-DESMETHYLCLOZAPINE
6104-71-8
|
US $6.60 / KG | 1KG | 97%-99% | 1kg -1000kg | Career Henan Chemical Co |
-
- N-DESMETHYLCLOZAPINE
6104-71-8
- US $6.60 / KG
- 97%-99%
- Career Henan Chemical Co
6104-71-8(N-DESMETHYLCLOZAPINE)Related Search:
N-DESMETHYLCLOZAPINE
8-CHLORO-11-(1-PIPERAZINYL)-5H-DIBENZO[B,E][1,4]DIAZEPINE
8-CHLORO-11-1[1-PIPERAZINYL)-5H-DIBENZO[B,E][1,4]DIAZEPINE
8-CHLORO-11-PIPERAZINYL-5H-DIBENZO[B,E][1,4]DIAZEPINE
CLOZAPINE, NORMETHYL(NORMETHYLCLOZAPINE, NOR-CLOZAPINE, DESMETHYLC
8-Chloro-11-piperazinyl-5H-dibenzo[b,e][1,4]diazepine, Norclozapine, Normethylclozapine
Normethylclozapine
5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(1-piperazinyl)-
Clozapine EP IMpurity C
N-Desmethylclozapine solution
N-Desmethyl Clozapine-d8 hydrochloride
8-Chloro-11-(piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine
Clozapine Impurity 3(Clozapine EP Impurity C)
Norclozapine Solution, 100ppm
NORCLOZAPINE; DESMETHYLCLOZAPINE; NORMETHYLCLOZAPINE
3-chloro-6-piperazin-1-yl-5H-benzo[b][1,4]benzodiazepine
Clozapine impurity 3/Clozapine EP Impurity C/Clozapine impurity A (USP)/8-chloro-11-(piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine
Desmethylclozapine (Norclozapine)
8-Chloro-11-(piperazin-1-yl)-5H-dib
Clozapine EP Impurity C (N-Desmethyl Clozapine)
Clozapine EP Impurity CQ: What is
Clozapine EP Impurity C Q: What is the CAS Number of
Clozapine EP Impurity C Q: What is the storage condition of
Clozapine EP Impurity C Q: What are the applications of
Clozapine EP Impurity C
NORCLOZAPINE
Desmethylclozapine
Norclozapine (ACP-104)
Clozapine Impurity C（EP）
6104-71-8
C17H17ClN4
3128
Various Metabolites and Impurities
Intermediates & Fine Chemicals
Metabolites & Impurities
Pharmaceuticals
Miscellaneous
Serotonin receptor