6-HYDROXY-2-NAPHTHYL DISULFIDE
- CAS No.
- 6088-51-3
- Chemical Name:
- 6-HYDROXY-2-NAPHTHYL DISULFIDE
- Synonyms
- DDD;DDD0;PIR 3.5;6,6'DDD (Analytical);AKOS BBS-00001974;TIMTEC-BB SBB005947;6′-Dithiodi(2-naphthol);6,6'-Dithiodi-2-naphthtol;6,6'-DITHIODI(2-NAPHTHOL)
- CBNumber:
- CB8198578
- Molecular Formula:
- C20H14O2S2
- Molecular Weight:
- 350.45
- MDL Number:
- MFCD00004083
- MOL File:
- 6088-51-3.mol
- MSDS File:
- SDS
| Melting point | 226 °C |
|---|---|
| Boiling point | 597.5±25.0 °C(Predicted) |
| Density | 1.46±0.1 g/cm3(Predicted) |
| storage temp. | −20°C |
| solubility | <26.28mg/ml in DMSO |
| form | powder to crystal |
| pka | 8.93±0.40(Predicted) |
| color | White to Brown |
| Merck | 14,2840 |
| CAS DataBase Reference | 6088-51-3(CAS DataBase Reference) |
| FDA UNII | Y4YW3C2D2S |
| Proposition 65 List | DDD (Dichlorodiphenyldichloroethane) |
| EPA Substance Registry System | 2-Naphthalenol, 6,6'-dithiobis- (6088-51-3) |
6-HYDROXY-2-NAPHTHYL DISULFIDE price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | D0244 | Bis(6-hydroxy-2-naphthyl) Disulfide >95.0%(HPLC) | 6088-51-3 | 1g | $114 | 2024-03-01 | Buy |
| Tocris | 4212 | PIR3.5 ≥98%(HPLC) | 6088-51-3 | 10 | $115 | 2021-12-16 | Buy |
| Tocris | 4212 | PIR3.5 ≥98%(HPLC) | 6088-51-3 | 50 | $388 | 2021-12-16 | Buy |
| Usbiological | 256259 | PIR 3.5 | 6088-51-3 | 10mg | $366 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD67127 | 2,2'-Dihydroxy-6,6'-dinaphthyldisulphide | 6088-51-3 | 10g | $376 | 2021-12-16 | Buy |
6-HYDROXY-2-NAPHTHYL DISULFIDE Chemical Properties,Uses,Production
Description
DDD, 1,1-dichloro-2,2-bis-(4-chlorophenyl) ethane, also known as TDE, is a metabolite of DDT, which found use in agriculture. As with DDT, the p,p -isomer is insecticidal and the o,p -isomer is an impurity.
Uses
For determination of protein-bound sulfhydryl groups.
Purification Methods
It crystallises as leaflets from AcOH and is slightly soluble in EtOH, and AcOH, but is soluble in *C6H6 and in alkalis to give a yellow solution. [Zincke & Dereser Chem Ber 51 352 1918.] The acetoxy derivative has m 198-200o (from AcOH or dioxane/MeOH), and the diacetyl derivative has m 167-168o (from AcOH). A small amount of impure disulfide can be purified by dissolving it in a small volume of Me2CO and adding a large volume of toluene, filter rapidly and concentrate to one-third of its volume. The hot toluene solution is filtered rapidly from any tarry residue, and crystals separate on cooling. Recrystallisation from hot acetic acid gives crystals with m 220-223o [Barrett & Seligman Science 116 323 1952]. [Beilstein 6 I 481.]
Toxicity evaluation
Animal Studies. DDD is less acutely toxic
than DDT (29), with an oral LD50 of 3400 to 4000 mg/kg in
the rat and a dermal LD50 ca. 1200 mg/kg in the rabbit. In a
2-year chronic dietary study in the rat, a LOEL of 100 ppm
(5 mg/kg/day) was quoted for tissue damage, similar to that
produced by DDT.
Human Studies. Most of the studies conducted in
humans have used the o,p -isomer of DDD. This has been
used as a drug, with medical and veterinary uses, for the
treatment of Cushing’s syndrome and adrenal carcinoma,
under the generic name of mitotane. After oral ingestion,
o,p’-DDD binds to lung and adrenal tissue. Its toxicity to the
adrenal appears to be species-dependent, however, causing
gross atrophy in the dog and reducing corticosteroid
production without pathological effects in other mammals,
including humans.
6-HYDROXY-2-NAPHTHYL DISULFIDE Preparation Products And Raw materials
6-HYDROXY-2-NAPHTHYL DISULFIDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
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