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Sodium dihydrogen phosphate dihydrate

Description References
Sodium dihydrogen phosphate dihydrate
Sodium dihydrogen phosphate dihydrate structure
Chemical Name:
Sodium dihydrogen phosphate dihydrate
Molecular Formula:
Formula Weight:
MOL File:

Sodium dihydrogen phosphate dihydrate Properties

Melting point:
60 °C
1,915 g/cm3
storage temp. 
Store at +5°C to +30°C.
H2O: 1 M at 20 °C, clear, colorless
4.0-4.5 (25℃, 50mg/mL in H2O)
Water Solubility 
λ: 260 nm Amax: 0.085
λ: 280 nm Amax: 0.070
CAS DataBase Reference
13472-35-0(CAS DataBase Reference)
  • Risk and Safety Statements
Hazard Codes  Xi
Risk Statements  36-36/37/38
Safety Statements  39-26-24/25-36
WGK Germany  1
RTECS  WA1900500
HS Code  2835 22 00
Toxicity LD50 orally in Rabbit: 8290 mg/kg LD50 dermal Rabbit > 7940 mg/kg

Sodium dihydrogen phosphate dihydrate price More Price(20)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 04269 Sodium phosphate monobasic dihydrate 98-100.5% (calc. to the dried substance), meets analytical specification of Ph. Eur., BP, USP, FCC, E 339 13472-35-0 1kg $45.6 2018-11-13 Buy
Sigma-Aldrich 04269 Sodium phosphate monobasic dihydrate 98-100.5% (calc. to the dried substance), meets analytical specification of Ph. Eur., BP, USP, FCC, E 339 13472-35-0 6x1kg $184 2018-11-13 Buy
Alfa Aesar A11316 Sodium dihydrogen phosphate dihydrate, 99% 13472-35-0 100g $22.4 2018-11-13 Buy
Alfa Aesar A11316 Sodium dihydrogen phosphate dihydrate, 99% 13472-35-0 500g $30.3 2018-11-13 Buy
Sigma-Aldrich 1.06342 Sodium dihydrogen phosphate dihydrate for analysis EMSURE Reag. Ph Eur 13472-35-0 1063420250 $43 2018-11-23 Buy

Sodium dihydrogen phosphate dihydrate Chemical Properties,Uses,Production


Sodium Dihydrogen Phosphate occurs as two forms: the crystal form (dihydrate) called Sodium Dihydrogen Phosphate (crystal) and anhydrous form called Sodium Dihydrogen Phosphate (anhydrous)
It is used as an acidity regulator and sequestrant in foods. It is used as a pH buffer (baking powders, fleet enema solution, electroplating baths, and acid cleaners), emulsifier, laboratory reagent, metal phosphating reagent, and textile dyeing/printing auxiliary. It is also used to treat boiled water and waste waster and to remove halogen from waste gases. Furthermore, it is used as a cattle feed supplement, as nutritional supplement in food, in dentrifice formulations, in vitreous enamel frits, for the synthesis of pharmaceuticals, and as a phosphate source for micro-organisms in effluent treatment.



Chemical Properties

white crystalline solid

Chemical Properties

The USP 32 states that monobasic sodium phosphate contains one or two molecules of water of hydration or is anhydrous.
The hydrated forms of monobasic sodium phosphate occur as odorless, colorless or white, slightly deliquescent crystals. The anhydrous form occurs as a white crystalline powder or granules.

Production Methods

Monobasic sodium phosphate is prepared by adding phosphoric acid to a hot, concentrated solution of disodium phosphate until the liquid ceases to form a precipitate with barium chloride. This solution is then concentrated and the monobasic sodium phosphate is crystallized.

Pharmaceutical Applications

Monobasic sodium phosphate is used in a wide variety of pharmaceutical formulations as a buffering agent and as a sequestering agent. Therapeutically, monobasic sodium phosphate is used as a mild saline laxative and in the treatment of hypophosphatemia.
Monobasic sodium phosphate is also used in food products, for example, in baking powders, and as a dry acidulant and sequestrant.


Monobasic sodium phosphate is widely used as an excipient in parenteral, oral, and topical pharmaceutical formulations.
Phosphate occurs extensively in the body and is involved in many physiological processes since it is the principal anion of intracellular fluid. Most foods contain adequate amounts of phosphate, making hypophosphatemia virtually unknown except in certain disease states or in patients receiving total parenteral nutrition. Treatment is usually by the oral administration of up to 100 mmol of phosphate daily.
Approximately two-thirds of ingested phosphate is absorbed from the gastrointestinal tract, virtually all of it being excreted in the urine, and the remainder is excreted in the feces. Excessive administration of phosphate, particularly intravenously, rectally, or in patients with renal failure, can cause hyperphosphatemia that may lead to hypocalcemia or other severe electrolyte imbalances. Adverse effects occur less frequently following oral consumption, although phosphates act as mild saline laxatives when administered orally or rectally (2–4 g of monobasic sodium phosphate in an aqueous solution is used as a laxative). Consequently, gastrointestinal disturbances including diarrhea, nausea, and vomiting may occur following the use of monobasic sodium phosphate as an excipient in oral formulations. However, the level of monobasic sodium phosphate used as an excipient in a pharmaceutical formulation is not usually associated with adverse effects.
LD50 (rat, IM): 0.25 g/kg(10)
LD50 (rat, oral): 8.29 g/kg


Monobasic sodium phosphate is chemically stable, although it is slightly deliquescent. On heating at 100°C, the dihydrate loses all of its water of crystallization. On further heating, it melts with decomposition at 205℃, forming sodium hydrogen pyrophosphate, Na2H2P2O7. At 250℃ it leaves a final residue of sodium metaphosphate, NaPO3.
Aqueous solutions are stable and may be sterilized by autoclaving.
Monobasic sodium phosphate should be stored in an airtight container in a cool, dry place.


Monobasic sodium phosphate is an acid salt and is therefore generally incompatible with alkaline materials and carbonates; aqueous solutions of monobasic sodium phosphate are acidic and will cause carbonates to effervesce.
Monobasic sodium phosphate should not be administered concomitantly with aluminum, calcium, or magnesium salts since they bind phosphate and could impair its absorption from the gastrointestinal tract. Interaction between calcium and phosphate, leading to the formation of insoluble calcium phosphate precipitates, is possible in parenteral admixtures.

Regulatory Status

GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (injections; infusions; ophthalmic, oral, topical, and vaginal preparations). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Sodium dihydrogen phosphate dihydrate Preparation Products And Raw materials

Raw materials

Preparation Products

Sodium dihydrogen phosphate dihydrate Suppliers

Global( 161)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 21676 58
Jiangsu Kolod Food Ingredients Co.,Ltd.
+86-518-85110578 18805133257
+86-518-85110578 CHINA 100 60
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32447 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 China 1861 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038 CHINA 3623 58
career henan chemical co
+86-371-86658258 CHINA 30001 58
Chemwill Asia Co.,Ltd.
86-21-51861608;;; CHINA 23980 58
Hubei Jusheng Technology Co.,Ltd.
027-59599243 CHINA 28236 58
Haihang Industry Co.,Ltd
+86 531 8582 1093 CHINA 8921 58

View Lastest Price from Sodium dihydrogen phosphate dihydrate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-07-11 Sodium dihydrogen phosphate dihydrate
US $1.00 / KG 1KG 99% 25kg career henan chemical co
2017-08-30 Sodium Dihydrogen Phosphate Dihydrate;Monosodium Phosphate Dihydrate
US $1.00 / KG 25KG 98.0%---103.0% 200 tons Jiangsu Kolod Food Ingredients Co.,Ltd.

Sodium dihydrogen phosphate dihydrate Spectrum

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