EC 3.4.22.1
- CAS No.
- 9047-22-7
- Chemical Name:
- EC 3.4.22.1
- Synonyms
- CATHEPSIN B;EC 3.4.22.1;Cathepsin II;units/mg protein;Native Human Cathepsin B;Native Bovine Cathepsin B;CATHEPSIN B, BOVINE SPLEEN;CATHEPSIN B1, BOVINE SPLEEN;CATHEPSIN B FROM HUMAN LIVER;CATHEPSIN B FROM BOVINE SPLEEN
- CBNumber:
- CB8206132
- Molecular Formula:
- NULL
- Molecular Weight:
- 0
- MDL Number:
- MFCD00130748
- MOL File:
- Mol file
| storage temp. | -70°C |
|---|---|
| solubility | H2O: soluble1.0mg/mL, clear |
| form | lyophilized powder |
| EWG's Food Scores | 1 |
| FDA UNII | 4YA7UX7KOP |
EC 3.4.22.1 price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C6286 | Cathepsin B from bovine spleen lyophilized powder, ≥10?units/mg protein | 9047-22-7 | 10units | $203 | 2024-03-01 | Buy |
| Sigma-Aldrich | C6286 | Cathepsin B from bovine spleen lyophilized powder, ≥10?units/mg protein | 9047-22-7 | 25units | $403 | 2024-03-01 | Buy |
| Sigma-Aldrich | C8571 | Cathepsin B from human liver buffered aqueous solution, ≥1,500?units/mg protein (E1%/280) | 9047-22-7 | 25μg | $468 | 2024-03-01 | Buy |
| Sigma-Aldrich | C6286 | Cathepsin B from bovine spleen lyophilized powder, ≥10?units/mg protein | 9047-22-7 | 100units | $1200 | 2024-03-01 | Buy |
| Sigma-Aldrich | C0150 | Cathepsin B from human placenta lyophilized powder, ≥5?units/mg protein | 9047-22-7 | 2units | $86.8 | 2024-03-01 | Buy |
EC 3.4.22.1 Chemical Properties,Uses,Production
Uses
Cathepsin B from human liver has been used:
- as a positive control in the screening Cathepsin B inhibitor assay
- in wall extension (expansin activity) assay
- in microinjection human foreskin fibroblasts to test its effect on apoptosis induction
Uses
Cathepsin B is a lysosomal cysteine proteinase which hydrolyzes proteins with a broad specificity for peptide bonds. Cathepsin B may be a useful tool in Alzheimer′s research, as it may have a role in the natural defense against the disease . Cathepsin B may be used to cleave procaspase 1 and procaspase 11, and to induce apoptosis in digitonin-permeabilized cells.
General Description
Cathepsin B gene is mapped to human chromosome 8p23.1. It is a lysosomal cysteine with 252 amino acids distributed in two chains and is homologous to rat liver sequence. It has disc shaped structure with two domains namely the left-hand ′L′ domain at the amino terminal and right hand ′R′ domain at the carboxyl-terminal.
Biochem/physiol Actions
Cathepsin B displays an endopeptidase and peptidyl dipeptidase activities. It may be associated with the pathophysiology of tumors. Cathepsin B is also regarded as a prominent protease in Leishmaniasis. It is overactivated in muscular dystrophy, pulmonary emphysema, and bone resorption.
Purification Methods
Cathepsin B is purified by affinity chromatography on the semicarbazone of Gly-Phe-glycinal-linked to Sepharose 4B, with elution by 2,2'-dipyridyl disulfide [Rich et al. Biochem J 235 731 1986, Methods Enzymol 80 551 1981].
EC 3.4.22.1 Preparation Products And Raw materials
Raw materials
Preparation Products
EC 3.4.22.1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Creative Enzymes | 1-516-855-7709 | info@creative-enzymes.com | United States | 8748 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10326 | 58 |
| HONG KONG IPURE BIOLOGY CO.,LIMITED | 86 18062405514 18062405514 | ada@ipurechemical.com | CHINA | 3465 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33349 | 58 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4428 | 55 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Shanghai Jizhi Biochemical Technology Co. Ltd. | 400-400-400-9004166 18616739031 | 3007523370@qq.com | China | 52712 | 58 |
| Guangzhou Tomums Life Science Co., Ltd. | 020-31155029 18902330969 | sales@tomums.cn | China | 4698 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
| Hubei Guangao Biotechnology Co., Ltd | 027-027-59223056 18162699093 | 1208480011@qq.com | China | 9951 | 58 |
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