ChemicalBook >> CAS DataBase List >>4’-[(2-butyl-4-chloro-5-hydroxymethyl)-1H-imidazol-1-yl)methyl]-[1,1’-Biphenyl]-2-carbonitrile

4’-[(2-butyl-4-chloro-5-hydroxymethyl)-1H-imidazol-1-yl)methyl]-[1,1’-Biphenyl]-2-carbonitrile

4’-[(2-butyl-4-chloro-5-hydroxymethyl)-1H-imidazol-1-yl)methyl]-[1,1’-Biphenyl]-2-carbonitrile structure

CAS No.: 114772-55-3

Chemical Name:: 4’-[(2-butyl-4-chloro-5-hydroxymethyl)-1H-imidazol-1-yl)methyl]-[1,1’-Biphenyl]-2-carbonitrile

Synonyms: Losartan Impurity 8;1'-Biphenyl]-2-carbonitrile;Benzene,1,3,5-tribromo-2,4,10-trimethyl-;4'-[(2-Butyl-4-chloro-5-hydroxymethyl-1H-;Des[2'-(1H-tetrazol-5-yl)] 2-Cyanolosartan;4'-[(2-butyl-4-chloro-5-hydroxymethyl)-1H-imidazol-1-yl)methyl]-[1;4′-(2-butyl-4-chloro-5-hydroxyMethyliMidzole-1-ylMethyl)- biphenyl-2-carbonitrile;2-[4-[[2-butyl-4-chloro-5-(hydroxymethyl)imidazol-1-yl]methyl]phenyl]benzonitrile;4'-{[2-butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl]methyl}biphenyl-2-carbonitrile;2-(4-{[2-Butyl-4-chloro-5-(hydroxymethyl)imidazolyl]methyl} phenyl)benzene carbonitrile

CBNumber:: CB82103743

Molecular Formula:: C22H22ClN3O

Molecular Weight:: 379.88

MDL Number:: MFCD16619233

MOL File:: 114772-55-3.mol

MSDS File:: SDS

Last updated:2023-04-23 13:52:06

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4’-[(2-butyl-4-chloro-5-hydroxymethyl)-1H-imidazol-1-yl)methyl]-[1,1’-Biphenyl]-2-carbonitrile Properties

Melting point	157-158°C
Boiling point	605.6±55.0 °C(Predicted)
Density	1.19
storage temp.	Refrigerator
solubility	DMSO (Slightly), Ethyl Acetate (Slightly)
pka	13.66±0.10(Predicted)
form	Solid
color	White to Off-White

4’-[(2-butyl-4-chloro-5-hydroxymethyl)-1H-imidazol-1-yl)methyl]-[1,1’-Biphenyl]-2-carbonitrile price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	D297670	Des[2’-(1H-tetrazol-5-yl)]2-Cyanolosartan	114772-55-3	500mg	$145	2021-12-16	Buy
Biosynth Carbosynth	FB152696	4'-[(2-Butyl-4-chloro-5-hydroxymethyl-1H-imidazol-1-yl)methyl]-1,1'-biphenyl-2-carbonitrile	114772-55-3	10mg	$203	2021-12-16	Buy
Biosynth Carbosynth	FB152696	4'-[(2-Butyl-4-chloro-5-hydroxymethyl-1H-imidazol-1-yl)methyl]-1,1'-biphenyl-2-carbonitrile	114772-55-3	25mg	$405	2021-12-16	Buy
American Custom Chemicals Corporation	API0027214	LOSARTAN POTASSIUM RELATED COMPOUND B 95.00%	114772-55-3	5MG	$505.95	2021-12-16	Buy
Biosynth Carbosynth	FB152696	4'-[(2-Butyl-4-chloro-5-hydroxymethyl-1H-imidazol-1-yl)methyl]-1,1'-biphenyl-2-carbonitrile	114772-55-3	50mg	$704	2021-12-16	Buy

Product number	Packaging	Price	Buy
D297670	500mg	$145	Buy
FB152696	10mg	$203	Buy
FB152696	25mg	$405	Buy
API0027214	5MG	$505.95	Buy
FB152696	50mg	$704	Buy

4’-[(2-butyl-4-chloro-5-hydroxymethyl)-1H-imidazol-1-yl)methyl]-[1,1’-Biphenyl]-2-carbonitrile Chemical Properties,Uses,Production

Uses

Des[2’-(1H-tetrazol-5-yl)] 2-Cyanolosartan is a derivative of Losartan Potassium (L470500), a an angiotensin II antagonist and is commonly used to significantly reduce risk of new onset atrial fibrillation and associated stroke in high-risk patients.

4’-[(2-butyl-4-chloro-5-hydroxymethyl)-1H-imidazol-1-yl)methyl]-[1,1’-Biphenyl]-2-carbonitrile synthesis

Synthesis of 4’-[(2-butyl-4-chloro-5-hydroxymethyl)-1H-imidazol-1-yl)methyl]-[1,1’-Biphenyl]-2-carbonitrile from 2-Butyl-4-chloro-5-formylimidazole and 4-Bromomethyl-2-cyanobiphenyl

4’-[(2-butyl-4-chloro-5-hydroxymethyl)-1H-imidazol-1-yl)methyl]-[1,1’-Biphenyl]-2-carbonitrile Preparation Products And Raw materials

Raw materials

Methyl Pentanimidate 4'-Methyl-2-cyanobiphenyl (2-BUTYL-5-CHLORO-1H-IMIDAZOL-4-YL)METHANOL 3-(4-BROMOBENZYL)-2-BUTYL-4-CHLORO-1H-IMIDAZOL-5-YLMETHANOL Des[2'-(1H-tetrazol-5-yl)] 2-Cyanolosartan Carboxaldehyde

2-(2-METHOXYPHENYL)-4,4-DIMETHYL-2-OXAZOLINE N-(2-HYDROXY-1,1-DIMETHYLETHYL)-2-METHOXYBENZENECARBOXAMIDE 2-Butyl-4-chloro-5-formylimidazole 4,4-DIMETHYL-2-(4'-METHYL-2-BIPHENYLYL)-2-OXAZOLINE Valeronitrile

o-Anisoyl chloride o-Anisic acid 4-Bromomethyl-2-cyanobiphenyl

1of3

Preparation Products

Losartan potassium

4’-[(2-butyl-4-chloro-5-hydroxymethyl)-1H-imidazol-1-yl)methyl]-[1,1’-Biphenyl]-2-carbonitrile Suppliers

Global( 80)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58
AFINE CHEMICALS LIMITED	0571-85134551	info@afinechem.com	CHINA	15377	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	CHINA	52867	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
sgtlifesciences pvt ltd	+8617013299288	dj@sgtlifesciences.com	China	12382	58
LUYUNJIA CHEMISTRY XIAMEN LIMITED	+86-592-5360779 +86-13055435203		China	5996	58
PT CHEM GROUP LIMITED	+86-85511178 +86-85511178	peter68@ptchemgroup.com	China	35453	58
ZHEJIANG JIUZHOU CHEM CO., LTD	+86-0576225566889 +86-13454675544	admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com	China	20000	58
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Supplier	Advantage
Hubei Jusheng Technology Co.,Ltd.	58
CONIER CHEM AND PHARMA LIMITED	58
AFINE CHEMICALS LIMITED	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Zhejiang J&C Biological Technology Co.,Limited	58
sgtlifesciences pvt ltd	58
LUYUNJIA CHEMISTRY XIAMEN LIMITED	58
PT CHEM GROUP LIMITED	58
ZHEJIANG JIUZHOU CHEM CO., LTD	58
GIHI CHEMICALS CO.,LIMITED	58

4’-[(2-butyl-4-chloro-5-hydroxymethyl)-1H-imidazol-1-yl)methyl]-[1,1’-Biphenyl]-2-carbonitrile 4′-(2-butyl-4-chloro-5-hydroxyMethyliMidzole-1-ylMethyl)- biphenyl-2-carbonitrile Des[2'-(1H-tetrazol-5-yl)] 2-Cyanolosartan 2-[4-[[2-butyl-4-chloro-5-(hydroxymethyl)imidazol-1-yl]methyl]phenyl]benzonitrile 4'-[(2-BUTYL-4-CHLORO-5-HYDROXYMETHYL-1H-IMIDAZOL-1-YL)METHYL]-1,1'-BIPHENYL-2-CARBONITRILE 114772-55-3 [1,1'-Biphenyl]-2-carbonitrile, 4'-[[2-butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl]methyl]- 4'-{[2-butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl]methyl}biphenyl-2-carbonitrile 4'-[(2-butyl-4-chloro-5-hydroxymethyl)-1H-imidazol-1-yl)methyl]-[1 1'-Biphenyl]-2-carbonitrile Losartan Impurity 8 2-(4-{[2-Butyl-4-chloro-5-(hydroxymethyl)imidazolyl]methyl} phenyl)benzene carbonitrile Benzene,1,3,5-tribromo-2,4,10-trimethyl- Losartan Related Compound B 4’-[(2-butyl-4-chloro-5-hydroxymethyl)-1H-imidazol-1- yl)methyl]-[1,1’-Biphenyl]-2-carbonitrile 4'-[(2-Butyl-4-chloro-5-hydroxymethyl-1H- 114772-55-3 Losartan Potassium