ChemicalBook >> CAS DataBase List >>3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione

3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione

3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione structure

CAS No.: 905854-02-6

Chemical Name:: 3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione

Synonyms: CS-74;Tivantinib;TIVANTINIB ARQ-197;ARQ 197, Tivantinib;ARQ197; ARQ-197; ARQ 197;Tivantinib/ARQ197/ARQ-197;3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione;RSYY3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione;(3R,4R)-3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dio;(3R,4R)-3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-2,5-pyrrolidinedione

CBNumber:: CB82123239

Molecular Formula:: C23H19N3O2

Molecular Weight:: 369.42

MDL Number:: MFCD11977597

MOL File:: 905854-02-6.mol

Last updated:2023-05-18 11:31:21

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3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione Properties

Boiling point	715.9±60.0 °C(Predicted)
Density	1.49
storage temp.	-20°C Freezer, Under inert atmosphere
solubility	DMSO (Slightly), Methanol (Slightly)
pka	9.28±0.70(Predicted)
form	Solid
color	Light Orange
FDA UNII	PJ4H73IL17
NCI Drug Dictionary	tivantinib

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08
Signal word	Danger
Hazard statements	H373-H360
Precautionary statements	P260-P314-P501

3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione price More Price(32)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	17135	Tivantinib ≥98%	905854-02-6	1mg	$36	2024-03-01	Buy
Cayman Chemical	17135	Tivantinib ≥98%	905854-02-6	5mg	$78	2024-03-01	Buy
Cayman Chemical	17135	Tivantinib ≥98%	905854-02-6	10mg	$120	2024-03-01	Buy
TRC	T447200	Tivantinib	905854-02-6	250mg	$615	2021-12-16	Buy
Usbiological	474198	Tivantinib	905854-02-6	100mg	$1677	2021-12-16	Buy

Product number	Packaging	Price	Buy
17135	1mg	$36	Buy
17135	5mg	$78	Buy
17135	10mg	$120	Buy
T447200	250mg	$615	Buy
474198	100mg	$1677	Buy

3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione Chemical Properties,Uses,Production

Uses

Tivantinib is a hepatocyte growth factor receptor (proto-oncogene c-Met; MET) inhibitor. Tivantinib inhibits human c-Met receptor tyrosine kinase selectively and is a promising therapeutic option for the treatment of c-Met-associated cancers. Potent c-MET inhibitor.

Uses

Definition

ChEBI: LSM-1131 is a member of indoles.

Biological Activity

tivantinib (arq 197) is an oral, non–adenosine triphosphate-competitive, selective, small-molecule met proto-oncogene (c-met) inhibitor. the calculated inhibitory constant (ki) for tivantinib to inhibit recombinant human c-met was approximately 355 nmol/l.c-met, a type of receptor tyrosine kinase, is a high-affinity receptor of the hepatocyte growth factor (hgf). dysregulated hgf/c-met-signaling pathway frequently occurs in human cancer [1].tivantinib had weak inhibitory effects on vegf receptor-3 (flt4), p21-activated kinase 3, calmodulin-dependent kinase ii delta, and pim-1 [1]. tivantinib displayed cytotoxic activity against a wide panel of human tumor cell lines with an ec50 ranging from 300-600 nmol/l [4]. remarkably, a549, h3122, pc9 (del e746_a750), pc9 gr4 (del e746_a750/t790m), hcc827, hcc827 gr6, h1993 and ebc-1 cell lines showed some degree of sensitivity to tivantinib, with ic50s ranging between 0.36 and 0.8 μm [5]. in tumor cell lines, gtl-16, mkn-45, hs746t, snu-5, ebc-1, h1993, nci-h441, a549, hct-116, u87-mg, a2780, and tov-112d, tivantinib indiscriminately inhibited cell proliferation independently of c-met gene amplification and met protein expression with an ec50 ranging from 60 to 600 nmol/l. further research showed that tivantinib promotes mitotic arrest, prevents cells from re-entering g1, and drives them to apoptosis, and induces programmed cell death regardless of the presence or absence of a functional met kinase [4].tivantinib has demonstrated antitumor activity in a wide range of human tumor cell lines and in xenograft models of human lung, colon, prostate, pancreas, and breast cancer [1] [2] [3]. female 4-week-old athymic nude (nu/nu) mice were used as experimental animals. tivantinib at a dose of 120 mg/kg significantly inhibited tumor burden in the bone of treated animals compared with the controls, starting from 14 to 21 days after cell injection. increasing doses of tivantinib decreased the number and the extent of osteolytic lesions [6].

target

c-Met

References

[1]. ryohei katayama, aki aoyama, takao yamori, et al. cytotoxic activity of tivantinib (arq 197) is not due solely to c-met inhibition. cancer research, 2013, 73(10): 3087-3097.
[2]. andrew j.wagner, john m. goldberg, steven g. dubois, et al. tivantinib (arq 197), a selective inhibitor of met, in patients with microphthalmia transcription factor–associated tumors. cancer, 2012: 5894-5902.
[3]. n. yamamoto, h. murakami, t. nishina, et al. the effect of cyp2c19 polymorphism on the safety, tolerability, and pharmacokinetics of tivantinib (arq 197): results from a phase i trial in advanced solid tumors. annals of oncology, 2013, 00: 1–7.
[4]. cristina basilico, selma pennacchietti, elisa vigna, et al. tivantinib (arq197) displays cytotoxic activity that is independent of its ability to bind met. clin cancer res, 2013, 19(9):2381-92.
[5]. cristina basilico, selma pennacchietti, elisa vigna, et al. tivantinib (arq197) displays cytotoxic activity that is independent of its ability to bind met. clinical cancer research, 2013, 19(9): 2381–92.
[6]. sara previdi, giovanni abbadessa, francesca dalò, et al. breast cancer–derived bone metastasis can be effectively reduced through specific c-met inhibitor tivantinib (arq 197) and shrna c-met knockdown. mol cancer ther, 2011, 11(1):214-23.

3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione Preparation Products And Raw materials

Raw materials

Preparation Products

3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione Suppliers

Global( 127)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	967	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29220	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Hebei Duling International Trade Co. LTD	+8618032673083	sales05@hbduling.cn	China	15745	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Biochempartner	58
Hubei Jusheng Technology Co.,Ltd.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Career Henan Chemica Co	58
Dideu Industries Group Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
Hebei Duling International Trade Co. LTD	58

View Lastest Price from 3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2023-04-22	3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione Tivantinib 905854-02-6	US $50.00 / KG	1KG	99%	100 TONS	Hebei Duling International Trade Co. LTD

3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione Tivantinib
905854-02-6
US $50.00 / KG
99%
Hebei Duling International Trade Co. LTD

3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione Spectrum

3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione(905854-02-6)¹HNMR

905854-02-6(3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione)Related Search:

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3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione Tivantinib 3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione Tivantinib (-)-3(R),4(R)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione, (-)-trans-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione TIVANTINIB ARQ-197 (3R,4R)-3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-2,5-pyrrolidinedione Tivantinib/ARQ197/ARQ-197 (3R,4R)-3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dio 2,5-Pyrrolidinedione,3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-, (3R,4R)- (3R,4R)-3-(2,3-dihydro-1H-pyrrolo[3,2,1-ij]quinolin-6-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione (3R,4R)-3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione Tivantinib ARQ 197, Tivantinib CS-74 ARQ197; ARQ-197; ARQ 197 3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione USP/EP/BP RSYY3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione 905854-02-6 Inhibitors