2,2,6,6-Tetramethyl-4-piperidinol
- CAS No.
- 2403-88-5
- Chemical Name:
- 2,2,6,6-Tetramethyl-4-piperidinol
- Synonyms
- 2,2,6,6-TETRAMETHYLPIPERIDIN-4-OL;2,2,6,6-tetramethylpiperidinol;4-HYDROXY-2,2,6,6-TETRAMETHYLPIPERIDINE;4-Piperidinol, 2,2,6,6-tetramethyl-;Tetramethylpiperidinol;TAA-OL;Lastar A;Triacetonalkamine;lastara;NSC 16575
- CBNumber:
- CB8213644
- Molecular Formula:
- C9H19NO
- Molecular Weight:
- 157.25
- MDL Number:
- MFCD00005983
- MOL File:
- 2403-88-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 129-131 °C(lit.) |
|---|---|
| Boiling point | 212-215 °C(lit.) |
| Density | 1.085 |
| refractive index | 1.4248 (estimate) |
| Flash point | 212-215°C |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | methanol: 0.1 g/mL, clear |
| form | Crystals, Crystalline Powder and/or Chunks |
| pka | 14.99±0.60(Predicted) |
| color | White to off-white or slightly beige |
| PH | 11.2 (4g/l, H2O, 20℃) |
| Water Solubility | 130 g/L (23 ºC) |
| BRN | 105039 |
| InChI | 1S/C9H19NO/c1-8(2)5-7(11)6-9(3,4)10-8/h7,10-11H,5-6H2,1-4H3 |
| InChIKey | VDVUCLWJZJHFAV-UHFFFAOYSA-N |
| SMILES | CC1(C)CC(O)CC(C)(C)N1 |
| CAS DataBase Reference | 2403-88-5(CAS DataBase Reference) |
| FDA UNII | IS23Q8EGZ6 |
| NIST Chemistry Reference | 4-Piperidinol, 2,2,6,6-tetramethyl-(2403-88-5) |
| EPA Substance Registry System | 4-Piperidinol, 2,2,6,6-tetramethyl- (2403-88-5) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314-H317 | |||||||||
| Precautionary statements | P260-P272-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | Xi,C | |||||||||
| Risk Statements | 36/37/38-43-34 | |||||||||
| Safety Statements | 26-36-45-36/37/39 | |||||||||
| RIDADR | UN3259 8/PG 2 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | TN7871675 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29333999 | |||||||||
| Storage Class | 8A - Combustible corrosive hazardous materials | |||||||||
| Hazard Classifications | Skin Corr. 1B Skin Sens. 1 |
|||||||||
| REACH Registrations | Active | |||||||||
| Limited Quantities | 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
2,2,6,6-Tetramethyl-4-piperidinol price More Price(51)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 115746 | 2,2,6,6-Tetramethyl-4-piperidinol 98% | 2403-88-5 | 10g | $93 | 2026-04-30 | Buy |
| Sigma-Aldrich | 115746 | 2,2,6,6-Tetramethyl-4-piperidinol 98% | 2403-88-5 | 25g | $137 | 2026-04-30 | Buy |
| TCI Chemical | T0910 | 4-Hydroxy-2,2,6,6-tetramethylpiperidine >98.0%(GC)(T) | 2403-88-5 | 25g | $52 | 2026-04-30 | Buy |
| TCI Chemical | T0910 | 4-Hydroxy-2,2,6,6-tetramethylpiperidine >98.0%(GC)(T) | 2403-88-5 | 500g | $409 | 2026-04-30 | Buy |
| Cayman Chemical | 44415 | Tetramethyl 4-piperinol ≥98% | 2403-88-5 | 10mg | $28 | 2026-04-30 | Buy |
2,2,6,6-Tetramethyl-4-piperidinol Chemical Properties, Uses, Production
Preparation
Step 1: Add tetramethylpiperidinone, catalyst, caustic soda flakes, and water to the high-pressure reactor and seal it.
Step 2: Purge the reactor with N2 to replace the air, then purge with H2 to replace the N2, and finally purge with H2 until the pressure reaches 0.8 MPa.
Step 3: First, maintain the pressure inside the reactor at 0.8 MPa. When the pressure drops, promptly replenish the reactor with H2 to 0.8 MPa while stirring and heating, controlling the temperature at 70-100°C. Repeat the above operation until the pressure inside the reactor remains at 0.8 MPa for a certain period of time without change, then stop the reaction.
Step 4: Purge the reactor with N2 to replace the H2, and simultaneously purge the reactor coils with cooling water to lower the temperature inside the reactor to below 50°C. Stop stirring, filter out the catalyst, and distill off some of the water.
Step 5: Stir and cool the remaining supersaturated mother liquor in an ice-water bath to crystallize, filter and wash to obtain 2,2,6,6-Tetramethyl-4-piperidinol, and recover and reuse the mother liquor.
Chemical Properties
white to slightly beige crystalline powder
Uses
2,2,6,6-tetramethyl-4-piperidinol has been used to study the irradiation of Camptothecin (CPT) in aerated dimethylsulfoxide (DMSO) solution that leads to formation of singlet oxygen.
Uses
An intermediate in the preparation of Piperidinyloxy free radical derivatives.
Synthesis Reference(s)
The Journal of Organic Chemistry, 37, p. 2050, 1972 DOI: 10.1021/jo00977a047
Purification Methods
The piperidine crystallises from water as a hydrate and crystallises from dry ether or *C6H6 as the anhydrous base. The hydrochloride has m 282-284o (from EtOH/H2O), and the formate has m 207o(dec, from EtOH/EtOAc). [Mailey & Day J Org Chem 22 1061 1957, Beilstein 21 I 195, 21 III/IV 146, 21/1 V 159.]
2,2,6,6-Tetramethyl-4-piperidinol Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jinan Wald Chemical Co., Ltd. | 0531-88773586 13210588999 | 304264064@qq.com | China | 192 | 58 |
| Nanjing Hike Biological Technology.,ltd | 025-52110956 17372769668 | sophia@njhkchem.com | China | 35 | 58 |
| Henan Guosheng Chemical Co., Ltd | 17610068021 | 1185586080@QQ.COM | China | 13 | 58 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16307 | 64 |
| Nantong Provikon Biotechnology Co., Ltd | 17505220108 | sales@provichem.cn | China | 84 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
View Latest Price from 2,2,6,6-Tetramethyl-4-piperidinol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-20 | 2,2,6,6-Tetramethyl-4-piperidinol
2403-88-5
|
$10.00 | 1kg | 99% | 3000MT | Nantong Provichem Biotech Co., Ltd. | |
 |
2026-08-25 | 2,2,6,6-Tetramethyl-4-piperidinol
2403-88-5
|
$2.20-8.80 | 1kg | 99%min | 1000kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2026-08-20 | 2,2,6,6-Tetramethyl-4-piperidinol
2403-88-5
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited |
-
- 2,2,6,6-Tetramethyl-4-piperidinol
2403-88-5
- $10.00
- 99%
- Nantong Provichem Biotech Co., Ltd.
-
- 2,2,6,6-Tetramethyl-4-piperidinol
2403-88-5
- $2.20-8.80
- 99%min
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- 2,2,6,6-Tetramethyl-4-piperidinol
2403-88-5
- $1.10
- 99.00%
- Dideu Industries Group Limited
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